Navigation Links
Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
Date:6/14/2011

Grand Rapids, Mich. (June 14, 2011) In a study recently published in Cancer Research, Van Andel Research Institute (VARI) researchers found a protein that could help predict the spread of the head and neck cancer nasopharyngeal carcinoma (NPC); this protein could also serve as part of a treatment strategy to stop the spread of the disease.

Though uncommon in the United States, NPC is one of the most common malignant tumors in southern China and Southeast Asia with incidence rates nearly 25 times that of most of the rest of the world. VARI researchers worked with scientists in Singapore, China, and the United States on the study.

"This study does not just report another molecular marker for metastasis of nasopharyngeal cancer, these investigators have revealed an important process related to this molecule," said Wei Zhang, Ph.D., Professor at M.D. Anderson Cancer Center. "Characterization of this process will open diverse opportunities for effective inhibition of this novel target for cancer metastasis."

NPC is the most common cancer originating in the nasopharynx area of the throat and has the highest metastasis rate among head and neck cancers. By the time patients are diagnosed, the disease has usually spread to lymph nodes or distant organs such as the liver.

Working together with physicians and scientists at Sun Yat-sen University Cancer Center in China, VARI researchers found that the protein serglycin is a marker of metastasis for NPC. Higher levels of serglycin correlated with an unfavorable prognosis and the increased likelihood that cancer would spread to other parts of the body. Additionally, when researchers blocked the secretion of serglycin, it reduced the cells capacity to invade and metastasize, which could mean it may have potential as a therapeutic target to stop the spread of NPC.

"Serglycin is clearly important to metastasis in NPC, but there are other factors as well," said Chao-Nan Qian, M.D. Ph.D., Senior Research Scientist in the Laboratory of Cancer and Developmental Cell Biology at VARI. Qian also served as a medical expert for the "Healthy China 2020" healthcare reform plan. "Finding genes that cooperate with Serglycin that are also involved in metastasis could result in a comprehensive approach to treat NPC, and potentially help it from from spreading."


'/>"/>

Contact: Joe Gavan
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Related medicine news :

1. Chairman Al Brandel of Lions Clubs International Foundation to Appear in Washington DC's National Memorial Day Parade
2. AADR awards the 2010 Distinguished Mentoring Award to Irwin D. Mandel
3. Lymphoma Research Foundation and John Theurer Cancer Center collaborate for Lymphoma Rounds program
4. ESC calls for research into vulnerable plaques
5. Researchers warn of fever from the forest
6. NIH researchers find new clues about aging
7. Hospital outcomes research named Article of the Year
8. Routine screening for autism not needed: McMaster researchers
9. Outstanding high school students receive AGA Research Foundation Fellowship Awards
10. Researchers work to turn back the clock on bone-producing stem cells
11. UT Southwestern research uncovers genetic link between emphysema, lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... January 18, 2017 , ... ... development solutions for drugs, biologics and consumer health products, today announced that Mr. ... at the upcoming WCBP Conference, to be held at the Mayflower Hotel, Washington ...
(Date:1/18/2017)... ... January 18, 2017 , ... The Hear ... aid project with the donation of cochlear implants. In February 2017, the first ... thus a fair chance of leading an independent life. This engagement builds on ...
(Date:1/18/2017)... ... January 18, 2017 , ... During pregnancy, women are at ... and those dental problems can increase the risk of pregnancy complications. Unfortunately, according ... failing to get the dental care they need. Agoura Hills dentist, Philip Shindler ...
(Date:1/17/2017)... ... January 17, 2017 , ... January is National Stalking Awareness Month (NSAM), now in ... the corners and commit the crime of stalking, a very real danger to many in ... overlooked factor in stalking and other crimes. , “Stalking: know it. Name it. Stop it.”—so ...
(Date:1/17/2017)... ... 17, 2017 , ... Gym Source, America’s leading retailer of premium residential and ... Hwy in Miami, FL. , “We are elated to be opening this new showroom,” ... is designed to give clients a seamless and motivating shopping experience.” , Every fitness ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... Food and Drug Administration CSL CureVac ... and Drug Administration FORT Fresenius Pharmaceuticals ... Klein GlaxoWellcome Global Influenza Programme Grippol ... Immune Targeting Systems Indian Association of Paediatrics Janssen ... Johnson Krka Pharmaceuticals Medicago Medicare ...
(Date:1/17/2017)... -- North America Insulin Delivery Market Outlook to 2022 ... Delivery Market Outlook to 2022", provides key market data ... provides value, in millions of US dollars, volume (in ... Insulin Pens, Insulin Pumps, Insulin Syringes and Traditional Insulin ... and distribution shares data for each of these market ...
(Date:1/17/2017)... , Jan 17, 2017 Research and Markets ... System Market 2016-2020" report to their offering. ... The global artificial pancreas devices ... period 2016-2020. Global Artificial Pancreas Devices System Market 2016-2020, ... from industry experts. The report covers the market landscape and its ...
Breaking Medicine Technology: