Navigation Links
Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
Date:6/14/2011

Grand Rapids, Mich. (June 14, 2011) In a study recently published in Cancer Research, Van Andel Research Institute (VARI) researchers found a protein that could help predict the spread of the head and neck cancer nasopharyngeal carcinoma (NPC); this protein could also serve as part of a treatment strategy to stop the spread of the disease.

Though uncommon in the United States, NPC is one of the most common malignant tumors in southern China and Southeast Asia with incidence rates nearly 25 times that of most of the rest of the world. VARI researchers worked with scientists in Singapore, China, and the United States on the study.

"This study does not just report another molecular marker for metastasis of nasopharyngeal cancer, these investigators have revealed an important process related to this molecule," said Wei Zhang, Ph.D., Professor at M.D. Anderson Cancer Center. "Characterization of this process will open diverse opportunities for effective inhibition of this novel target for cancer metastasis."

NPC is the most common cancer originating in the nasopharynx area of the throat and has the highest metastasis rate among head and neck cancers. By the time patients are diagnosed, the disease has usually spread to lymph nodes or distant organs such as the liver.

Working together with physicians and scientists at Sun Yat-sen University Cancer Center in China, VARI researchers found that the protein serglycin is a marker of metastasis for NPC. Higher levels of serglycin correlated with an unfavorable prognosis and the increased likelihood that cancer would spread to other parts of the body. Additionally, when researchers blocked the secretion of serglycin, it reduced the cells capacity to invade and metastasize, which could mean it may have potential as a therapeutic target to stop the spread of NPC.

"Serglycin is clearly important to metastasis in NPC, but there are other factors as well," said Chao-Nan Qian, M.D. Ph.D., Senior Research Scientist in the Laboratory of Cancer and Developmental Cell Biology at VARI. Qian also served as a medical expert for the "Healthy China 2020" healthcare reform plan. "Finding genes that cooperate with Serglycin that are also involved in metastasis could result in a comprehensive approach to treat NPC, and potentially help it from from spreading."


'/>"/>

Contact: Joe Gavan
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Related medicine news :

1. Chairman Al Brandel of Lions Clubs International Foundation to Appear in Washington DC's National Memorial Day Parade
2. AADR awards the 2010 Distinguished Mentoring Award to Irwin D. Mandel
3. Lymphoma Research Foundation and John Theurer Cancer Center collaborate for Lymphoma Rounds program
4. ESC calls for research into vulnerable plaques
5. Researchers warn of fever from the forest
6. NIH researchers find new clues about aging
7. Hospital outcomes research named Article of the Year
8. Routine screening for autism not needed: McMaster researchers
9. Outstanding high school students receive AGA Research Foundation Fellowship Awards
10. Researchers work to turn back the clock on bone-producing stem cells
11. UT Southwestern research uncovers genetic link between emphysema, lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... Ogden Clinic, the largest ... centric payment system, to expand its focus on patient care by providing an ... , “At Ogden Clinic, we are working to become a different type ...
(Date:3/23/2017)... , ... March 23, 2017 , ... “The Trainer”: ... of published author, Scotty, a fiction writer with an active imagination and an enthusiasm ... new book follows the tale of Wild Bill Hart, who sat looking at the ...
(Date:3/23/2017)... ... March 23, 2017 , ... Vortex Biosciences, provider ... protein expression in circulating tumor cells using microfluidic western blotting” in Nature Communications ... Vortex technology to capture CTCs and a microfluidic single-CTC resolution Western ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... publication of the first issue of its companion print magazine. The new magazine, ... cosmetic surgery thanks to information provided by board-certified doctors from across the country. ...
(Date:3/22/2017)... ... March 22, 2017 , ... Sam & Associates Insurance ... planning, and related services to residents of the region, is embarking on a ... species and wild lands. , Endangered Species International is committed to ending the ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017 /PRNewswire/ - INVICTUS MD ... IVITF; FRA: 8IS) Invictus MD announces that AB Laboratories ... in its licensed production facility under the Access to ... Hamilton, Ontario . The ... in October 2016, is currently operating at half capacity, ...
(Date:3/23/2017)... 23, 2017 Piramal Pharma ... anuncia el nombramiento de Stuart E. Needleman ... de servicios integrados completa para su base de ... clave en el crecimiento y ejecución de las ... de impulsar todas las actividades de desarrollo empresarial ...
(Date:3/23/2017)... TEL AVIV, Israel, March 23, 2017  Galmed ... or the "Company"), a clinical-stage biopharmaceutical company focused ... for the treatment of nonalcoholic steatohepatitis, or NASH, ... for the three and twelve months ended December 31, ... recently completed pre-clinical studies demonstrating Aramchol™,s potential direct ...
Breaking Medicine Technology: