Navigation Links
Van Andel Research Institute finding could lead to reduced side effects in anti-cancer antibiotics
Date:6/28/2011

Grand Rapids, Mich. (June 28, 2011) Most of us have had a doctor prescribe an antibiotic for a stubborn bacterial infection, or for a cut that gets infected. However, prescribing an antibiotic to fight cancer? In fact, anti-cancer antibiotics have been used since the 1950s to successfully treat several forms of cancer, but often the side effects limit the duration they can be given to a patient.

One particularly promising anti-cancer antibiotic is Geldanamycin and a modified form of this drug known as 17AAG. Despite its proven ability to selectively kill many different forms of cancer in laboratory studies, the use of these drugs is limited due to side effects, mainly liver failure, in patients.

Newly published results from Van Andel Research Institute (VARI) researchers have determined how the anti-cancer antibiotic Geldanamycin and its derivative 17AAG work in more detail and have uncovered a possible explanation for side effects observed in clinical trials of the drug.

"The article provides novel and significant information about the clinical potential of these compounds in cancer therapy," said Yale School of Medicine Professor and Chair of Pharmacology Joseph Schlessinger, Ph.D.

Although there was much preclinical interest in the antibiotic Geldanamycin as an anti-cancer drug, it turned out to be a poor candidate for clinical trials because of its toxicity. Derivatives such as 17AAG were developed to decrease toxicity and are still being evaluated in clinical trials.

VARI researchers determined how Geldanamycin and 17AAG work in more detail in a study published in Proceedings of the National Academy of Sciences U.S.A., which could inform future drug design, and also found a way to potentially decrease the antibiotics' toxicity.

"There was so much interest early on in Geldanamycin because it resulted in the degradation of oncoproteins, important protein targets in tumor cells," said VARI Research Scientist and lead author of the paper Qian Xie, M.D., Ph.D.

"If there is a chance of decreasing the toxicity of Geldanamycin and 17AAG, it would be a boon in the treatment of cancer," said George Vande Woude, Ph.D., head of the Laboratory of Molecular Oncology at VARI that published the study.


'/>"/>

Contact: Joe Gavan
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Related medicine news :

1. Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
2. Chairman Al Brandel of Lions Clubs International Foundation to Appear in Washington DC's National Memorial Day Parade
3. AADR awards the 2010 Distinguished Mentoring Award to Irwin D. Mandel
4. Religion benefits traumatic brain injury victims, Wayne State University research finds
5. Leading research organizations announce top-tier journal for biomedical and life sciences
6. New Crops for the Future Research Centre -- for food and non-food uses
7. Drug shows improved kidney function for type 2 diabetics, UT Southwestern researchers report
8. UH Cancer Center receives $3.58 million gift for mesothelioma research
9. New application for iPhone may support monitoring and research on Parkinsons disease
10. TGen, Tecan and ASU Biodesign Institute develop sample preparation solution for proteomic research
11. Researchers identify components of speech recognition pathway in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2017)... ... March 01, 2017 , ... ... pricing in the month of March for treatments aimed at tightening skin and ... use on Thermage skin tightening, with 30 percent off all Thermage face and ...
(Date:3/1/2017)... ... March 01, 2017 , ... “Cleansing Thoughts; Glimpses ... of those who hear His voice. “Cleansing Thoughts; Glimpses from My Personal Journal” ... who enjoys boating, gardening and crocheting baby items to donate to the Neonatal ...
(Date:3/1/2017)... , ... March 01, 2017 , ... “Our Pure Need of Obedience to the Law ... for His return. “Our Pure Need of Obedience to the Law of God” is the ... attend missionary school. He and his wife, Anika, and children have since dedicated their lives ...
(Date:2/28/2017)... (PRWEB) , ... March 01, 2017 , ... ... the acquisition of SmarterMe, a personal assistant for sales powered by an intelligent ... enterprises to work smarter. , SmarterMe is built grounds up keeping individual users ...
(Date:2/28/2017)... St. Louis, Missouri (PRWEB) , ... February 28, ... ... will gather to learn and share “Pathways to Success: 21st Century Solutions to ... in San Diego, Calif. , “Each year, the Intalere Executive Forum assembles ...
Breaking Medicine News(10 mins):
(Date:3/1/2017)... 1, 2017 The Thyroid Pharmacist, Dr. ... foremost authorities on the thyroid and thyroid conditions, as ... activism, has designed and launched a revolutionary new 9-part ... deeps into the realities of thyroid disease, dispelling the ... path to recovery.  Dr. Wentz, who graduated ...
(Date:3/1/2017)... , March 1, 2017 Bio-Techne Corporation has ... Diagnostics to release its first diagnostic tool for ... innovative parasitological system which contains the only non-toxic, ... system will be manufactured at Bio-Techne,s Diagnostic Division ... and leverages its state-of-art formulation, manufacturing, and packaging ...
(Date:3/1/2017)... 1, 2017  Integrated Modular Design (IMD), ... and implementation of pre-fabricated healthcare products like ... headwalls, seeks to lead the construction industry ... Fueled by their leading-edge pre-fabrication ... reducing construction timelines and project risk, and ...
Breaking Medicine Technology: