Navigation Links
Van Andel Institute study may lead to better, safer drug for diabetes
Date:11/21/2011

Grand Rapids, Mich. (November 21, 2011) A Van Andel Research Institute (VARI) study published recently in the Journal of Biological Chemistry reveals that a natural fatty acid can serve as a regulator of blood sugar levels, which may have important applications in designing better and safer drugs for diabetes treatment.

According to the U.S. Center for Disease Control and Prevention (CDC), nearly 26 million Americans have diabetes, and current drugs commonly used to treat the disease sometimes have unwanted side effects.

The study found that decanoic acid, a saturated fatty acid, acts as a modulator of a sub-family of nuclear receptors (peroxisome proliferator-activated or PPAR receptors) that play a key role in glucose and lipid metabolism.

Decanoic acid, also known as "Capric acid," occurs naturally in coconut oil and palm kernel oil, as well as in the milk and animal fats of some mammals. It is used in organic synthesis and is common in the manufacture of perfumes, lubricants, greases, rubber, dyes, plastics, food additives and pharmaceuticals.

"We studied a nuclear receptor (PPARγ) that plays a key role in glucose and lipid metabolism and is the molecular target of the thiazolidinedione (TZD) class of antidiabetic drugs, which have been shown to have negative side effects such as weight gain, fluid retention, and increased risk for cardiovascular diseases," said H. Eric Xu, Ph.D., Director of VARI's Center for Structural Biology and Drug Discovery. "Our results showed that decanoic acid could be used in designing better and safer PPARγ based drugs."

Xu's laboratory uses a technique known as X-ray crystallography to determine exactly how and why the drug compounds work in molecular detail, which can then help drug developers engineer more potent drugs that have fewer unwanted side effects. The lab has previously published studies that could impact a variety of diseases, including osteoporosis, diabetes, and anxiety and depression disorders.

The recent study, which was carried out in collaboration with a team of international research and clinical partners from Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, National University of Singapore, The Scripps Research Institute, Shanghai Institute of Materia Medica, and University of Michigan showed that decanoic acid is a direct ligand, or binding partner, of PPARγ, and binds and partially activates PPARγ without leading to the development of fat cells.

"Treatments with decanoic acid and its triglyceride form improve glucose sensitivity and lipid profiles without weight gain in diabetic models," said lead author Venkata R. Malapaka, Ph.D., who conducted his research at Van Andel Research Institute and now works as a Research Fellow in Brigham and Women's Hospital's Center for Interdisciplinary Cardiovascular Sciences. "Together, these results suggest that decanoic acid is a modulating ligand for PPARs and the structure can aid in designing better and safer PPARγ-based drugs."

In additional to the nearly 26 million Americans with diabetes, an estimated 79 million U.S. adults have prediabetes, a condition in which blood sugar levels are higher than normal, but not high enough to be diagnosed as diabetes. Prediabetes raises a person's risk of type 2 diabetes, heart disease and stroke. Diabetes affects 8.3 percent of Americans of all ages, and 11.3 percent of adults aged 20 and older. About 27 percent of those with diabetes7 million Americansdo not know they have the disease. Prediabetes affects 35 percent of adults aged 20 and older.


'/>"/>

Contact: Joe Gavan
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Related medicine news :

1. Van Andel Research Institute finding could lead to reduced side effects in anti-cancer antibiotics
2. Van Andel Research Institute finding is potential predictor of deadly cancer common in Asia
3. Chairman Al Brandel of Lions Clubs International Foundation to Appear in Washington DC's National Memorial Day Parade
4. AADR awards the 2010 Distinguished Mentoring Award to Irwin D. Mandel
5. Jeopardy! winnings spur IBM and Scripps Research Institute collaboration to fight against malaria
6. Mass. General Cancer Center and Vall dHebron Institute of Oncology biomarker alliance
7. US institute wraps up data collection in Russian Mars 520-day mission simulation
8. Scott & White Cancer Research Institute receives $3.5 million grant
9. Researchers get $3 million National Institutes of Health grant for mathematical models of prostate cancer aggressiveness
10. UNCs Rubinow elected to Institute of Medicine
11. Regenstrief Institute president to receive national recognition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Abilene, Texas (PRWEB) , ... October 13, 2017 , ... ... publication this week that explains one of the most popular and least understood books ... seems like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... Bethesda, MD (PRWEB) , ... October 12, 2017 , ... ... Award of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s ... 4 – 8. , In honor of Morris F. Collen, a pioneer in the ...
(Date:10/12/2017)... ... 2017 , ... Leading pediatric oncology experts at Children’s National Health System ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of ...
(Date:10/12/2017)... FL (PRWEB) , ... October 12, 2017 , ... ... presenting the latest in wound care advancements to physician colleagues, skilled nursing facility ... is titled, "Navigating the Treacherous Waters of Wound Care." , "At many of ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... 2017  Commended for their devotion to personalized service, SMP ... number one in the South Florida Business Journal,s 50 Fastest-Growing ... yearly list, the national specialty pharmacy has found its niche.  ... will soon be honored by SFBJ as the 2017 Power ... Set to receive his award in October, Bardisa said of ...
(Date:9/22/2017)... , Sept. 22, 2017  As the latest Obamacare ... Bill Cassidy (R-LA) and Lindsey Graham ... that the medical device industry is in an odd ... tax, the 2.3% excise tax on medical device sales ... also want covered patients, increased visits and hospital customers ...
(Date:9/18/2017)... , Sept. 18, 2017 EpiVax, ... of bioinformatics and immune engineering, today announced ... influenza A (H7N9) vaccine. ... to seasonal influenza and presents a challenge ... prior exposure to be effective. Using state-of-the-art ...
Breaking Medicine Technology: