Navigation Links
Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
Date:4/20/2012

THURSDAY, April 19 (HealthDay News) -- It's not clear whether patients with type 2 diabetes gain any long-term benefit from taking the blood sugar-lowering drug metformin and insulin together rather than insulin alone.

That's the conclusion of Danish researchers who reviewed data from 23 clinical trials involving more than 2,200 patients over the age of 18.

Reporting online April 19 in the BMJ, they found that taking metformin plus insulin leads to better blood sugar control, less weight gain and less need for insulin.

However, the researchers also noted that the clinical trials provided little information about long-term patient outcomes, such as the total numbers of deaths and deaths from cardiovascular disease.

This means that more clinical trials are needed to determine the long-term benefits and harms of the combination, specifically the risks of premature death.

The researchers, led by Bianca Hemmingsen of the Center for Clinical Intervention Research in Copenhagen, also believe that the combination of metformin and insulin raises the odds for severe low blood sugar (hypoglycemia), so further study is needed to assess the long-term benefits and harms of this regimen.

Currently, metformin is recommended in guidelines for type 2 diabetes patients starting on insulin.

One expert in the United States took issue with the findings.

"It certainly seems like a controversial statement since all our treatment is based on metformin with additional meds [insulin or otherwise] added when the blood sugar is no longer controlled and based on what an individual patient might need," said Dr. Mary Ann Banerji, director of the Diabetes Treatment Center at the State University of New York Downstate Medical Center, in New York City.

She added that, "I am unaware that there is more hypoglycemia with metformin plus insulin compared to insulin alone, since presumably one would not be put on insulin unless it was needed and other modalities [treatments] tried."

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes medicines.

-- Robert Preidt

SOURCES: Mary Ann Banerji, director, Diabetes Treatment Center, State University of New York Downstate Medical Center, New York City; British Medical Journal, news release, April 19, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study Casts Doubt on Value of Pricey Prostate Cancer Therapy
2. Middle school boys who are reluctant readers value reading more after using e-readers
3. Health Insurance Mandate Deemed Best Value for Money
4. Predicting the value of indexing symptoms for ovarian cancer
5. Uninsured receive same quantity, value of imaging services as insured in hospital, in-patient setting
6. Iowa State study finds health value to children of National School Lunch Program
7. New studies show progress, value in vaccination against deadly pneumonia
8. New York Academy of Sciences and GMEC host forum on value of animal models in drug discovery
9. Hospitals encouraged to consider value-added service of hospital-based radiology groups
10. New threshold values for fine particulates at the workplace
11. Value of hospital environmental services linked to efficiency not expenses
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Value of Metformin, Insulin Combo for Type 2 Diabetes Questioned
(Date:2/6/2016)... ... February 06, 2016 , ... With the FCPX LUT: Summer ... to their footage. A LUT is a Lookup Table that contains a mathematical formula ... indicated by the table. By manipulating each pixel, LUT's can change each color range ...
(Date:2/6/2016)... , ... February 06, 2016 , ... ... of eating disorder treatment helps to reduce the frequency and level of relapse. ... Recovery Phase: Re-Establishing Healthy Identity and Purpose,” will explore the critical tasks of ...
(Date:2/5/2016)... ... , ... Love is in the air at King Kullen! The local grocer ... This staple for Valentine’s Day is a must-have, and can be picked up with ... only are long-stem roses available, but also other flower bouquets, elegantly wrapped and ready ...
(Date:2/5/2016)... ... February 05, 2016 , ... Today, the Whole-Food Warrior ... that the much-anticipated feature with author Jahnavi Foster, specialist in healthy vegetarian cuisine, will ... , Each week, on his weekly Whole-Food Warrior TV show, Frank Davis highlights Whole-Food ...
(Date:2/5/2016)... ... 05, 2016 , ... The event is being held on April 7, 2016 ... Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research for the care and ... Parkinson’s disease and is the architect of this informative event to raise awareness and ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... 2016  The Senior Care Pharmacy Coalition (SCPC) ... Chairman Jason Chaffetz (R-UT) and Ranking ... hearing , "Developments in the Prescription Drug Market," ... questions about abusive pharmacy benefit manager (PBM) pricing ... Ranking Member Elijah Cummings (D-MD) are diligent, serious ...
(Date:2/4/2016)... , Feb. 4, 2016  Montoya Love is recognized ... the field of Pharmaceuticals. Montoya is the Regulatory Systems ... Manufacturing and selling ... Becton Dickinson provides healthcare institutions, clinical laboratories and ... fifty countries across the globe. ...
(Date:2/4/2016)... -- Mettler-Toledo International Inc. (NYSE: MTD ) today ... the highlights: , Sales in local currency ... year.  Reported sales decreased 3% as currency reduced sales ... earnings per diluted share as reported (EPS) were $4.44, ... EPS was $4.65, an increase of 10% over the ...
Breaking Medicine Technology: