Navigation Links
Valuable tool for predicting pain genes in people
Date:12/6/2012

Scientists in Australia and Austria have described a "network map" of genes involved in pain perception, with remarkable similarity from fruit flies to people. The work should help identify new analgesic drugs.

Dr Greg Neely from the Garvan institute of Medical Research in Sydney and Professor Josef Penninger from the Austrian Academy of Sciences in Vienna had previously screened the 14,000 genes in the fly genome and identified 580 genes identified with heat perception. In the current study, using a database from the US National Centre for Biotechnology Information, they noted roughly 400 equivalent genes in people, 35% of which are already suspected to be pain genes.

The map they constructed using fly and human data includes many known genes, as well as hundreds of new genes and pathways, and demonstrates exceptional evolutionary conservation of molecular mechanisms across species. This should not be surprising, as any creature must be able to identify a source of pain or danger in order to survive.

Comparing fly with human data, they could see that a particular kind of molecular signaling (phospholipid signaling), already implicated in pain processing, appeared in the pain network. Further, they demonstrated the importance of two enzymes that make phospholipids, by removing those enzymes from mice, making them hypersensitive to heat pain. These results are now published online in the international journal PLOS Genetics.

"Pain affects hundreds of millions of people and is a research field badly in need of new approaches and discoveries," said Dr Neely.

"The fact that evolution has done such a remarkable job of conserving pain genes across species makes our fly data very useful, because much of it translates to rodents and people.

"We are able to test our hypotheses in mice, and if a gene or pathway or process functions as we predict, there is a good chance it will also apply to people.

"B
'/>"/>

Contact: Iris Hui
iris.hui@researchaustralia.org
61-292-958-545
Research Australia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Video-assisted thoracic surgery valuable tool in lung cancer screening
2. Predicting, preventing, and controlling pandemics: Making the case for a strategic action plan
3. Researchers develop non-invasive technique for predicting patients response to chemotherapy
4. Study uncovers simple way of predicting severe pain following breast cancer surgery
5. A new model for predicting recovery after spinal cord injury
6. Predicting post-traumatic stress disorder before it happens
7. Study examines BI-RADS and MRI in predicting breast cancer
8. A relationship between cancer genes and the reprogramming gene SOX2 discovered
9. Patients with aberrations in two genes respond better to drugs blocking a well-known cancer pathway
10. 1000 genomes study is guidebook to how genes vary
11. New findings on mens genes could alter interpretation of PSA test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Heritage Woods of McLeansboro, a Gardant affordable ... Celebration on April 20 with a day full of ... and soul. , The community, which is located at ... of all incomes, including those on Medicaid, who need ... Week is observed every April and highlights the communities ...
(Date:4/17/2015)... April 18, 2015 Rosetta Radiology is ... rounding out their list of diagnostic imaging services. This ... patients on the Upper East Side of Manhattan. , ... full capacity. The addition of PET-CT, combined with Rosetta’s ... the ability to work with patients through several stages ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Riviera ... Dr. Kevin Sadati of the Gallery of Cosmetic ... County’s top beauty experts. The publication focused on ... facial stem cell fat grafting, eyelid surgery, laser resurfacing ... facial plastic surgery has resulted in thousands of ...
(Date:4/17/2015)... Tampa, Florida (PRWEB) April 17, 2015 ... Term Acute Care and Florida Hospital Carrollwood were all ... Hospital Wesley Chapel, located in Pasco County, is ranked ... Bay Times workplaces survey, which was conducted in partnership ... is an 83 all-private bed hospital that opened in ...
(Date:4/17/2015)... From the day Dr. Todd Phillips founded ... organization has empowered young people to create meaningful change in ... fresh water and the Gospel to all of Liberia by ... 17 and 27, students, faculty and staff raised $21,000 through ... water and the Good News of Jesus. , During ...
Breaking Medicine News(10 mins):Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 2Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 3Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 4Health News:The Last Well and Liberty U’s TEN Initiative raises $21,000 to Bring Fresh Water & The Gospel to 7,000 Liberians 2
... School of Medicine and colleagues discovered that the Notch ... types, and is also implicated in some cancers, is ... The findings appear this week in Cell Stem Cell, ... bone marrow stem cells. , Notch is one of ...
... the Head and Neck, NEW YORK, April 10 ... plastic and cosmetic surgery for the ethnic,patient, will speak ... day,Continuing Medical Education (CME) Accredited seminar entitled "Patient,Safety in ... 12 at the,University Club of New York., "Facial ...
... Support Event, ALEXANDRIA, Va., April 10 ... (NHDD), will be the largest,effort ever undertaken to ... "With healthcare, ,your decisions matter;, however, others ... Nathan A. Kottkamp, Chair, National,Healthcare Decisions Day. "All ...
... in wine that protect against dementia. This is shown in ... Sweden. , The findings are based on 1,458 women who ... 1968. When they were examined by physicians they were asked ... by selecting from seven categories on a scale from never ...
... - 7,000 deaths a year ... pharmacy error risk, - Half of consumers choose their pharmacies for ... ... One-third of America,s 225,million prescription-takers now report experiencing a prescription ...
... their children to a podiatrist,for foot ailments, BETHESDA, ... bring thousands of adults to doctors, offices every,day. But ... Medical Association (APMA) during April,s Foot Health Awareness,Month, many ... it comes to their children,s feet. In fact, only ...
Cached Medicine News:Health News:Developing cancer treatments directed at critical developmental pathway 2Health News:Dr. Edmund Kwan to Speak on Facial Contouring Among Asian Patients at Cosmetic Surgery Seminar 2Health News:National Healthcare Decisions Day in All 50 States, DC, Puerto Rico, and Internationally 2Health News:Wine may protect against dementia 2Health News:Prescription For Disaster: One-Third of Consumers Experience Prescription Errors, New Survey Finds 2Health News:Prescription For Disaster: One-Third of Consumers Experience Prescription Errors, New Survey Finds 3Health News:Pediatric Survey Reveals Many Parents Neglect Their Children's Feet 2
(Date:4/17/2015)... CAMBRIDGE, England , April 17, 2015 ... cancer genomics company announced today that their presence at the ... will include a presentation by co-founder Nitzan Rosenfeld ... is also attending April 18 th - 22 nd ... genome in plasma using ctDNA , forms part ...
(Date:4/17/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/dl9gbg/admetoxicology ) has ... Global Strategic Business Report" report to their offering. ... ADME-Toxicology Testing in US$ Million by the following Segments: ... The report provides separate comprehensive analytics for the ... , Europe , ...
(Date:4/17/2015)... Apr. 17, 2015 Research and Markets ... "Mammography Equipment - Global Strategic Business Report" ... the worldwide markets for Mammography Equipment in US$ Thousands ... Digital Mammography Equipment. The report provides separate comprehensive analytics ... Japan , Europe , ...
Breaking Medicine Technology:Inivata Co-founder Nitzan Rosenfeld to Present at AACR Annual Meeting 2ADME-Toxicology Testing (In-Vivo, & In-Vitro) Market - Global Strategic Business Report 2015: Pharma Industry Renews Focus on Cost Optimization 2Mammography Equipment (Analog & Digital) Market 2015-2020 - Global Strategic Business Report: Breast Imaging Screening Programs Push Sales 2
... a test capability extending to 80, the ... patient's visual field, allowing peripheral defects that ... to be explored. Practice Management Integration provides ... With the Medmont Studio package the practitioner ...
... Bore MR ,Siemens has combined, for the first ... very short 125 cm magnet and a powerful ... Open Bore MR. And MAGNETOM Espree, has the ... Siemens technology, which means faster, more precise results, ...
... resurfacing implant is an option for a ... option. The implant is secured by a ... coating or DuoFix HA on porous coating. ... arthritis, rheumatoid or moderately severe humeral head ...
... The S7 with Discrete Technology Coronary ... unmatched scaffolding. Proprietary Secure Technology stent ... pillows that partially encapsulate the stent ... Technology is designed to minimize balloon ...
Medicine Products: