Navigation Links
Valuable tool for predicting pain genes in people
Date:12/6/2012

Scientists in Australia and Austria have described a "network map" of genes involved in pain perception, with remarkable similarity from fruit flies to people. The work should help identify new analgesic drugs.

Dr Greg Neely from the Garvan institute of Medical Research in Sydney and Professor Josef Penninger from the Austrian Academy of Sciences in Vienna had previously screened the 14,000 genes in the fly genome and identified 580 genes identified with heat perception. In the current study, using a database from the US National Centre for Biotechnology Information, they noted roughly 400 equivalent genes in people, 35% of which are already suspected to be pain genes.

The map they constructed using fly and human data includes many known genes, as well as hundreds of new genes and pathways, and demonstrates exceptional evolutionary conservation of molecular mechanisms across species. This should not be surprising, as any creature must be able to identify a source of pain or danger in order to survive.

Comparing fly with human data, they could see that a particular kind of molecular signaling (phospholipid signaling), already implicated in pain processing, appeared in the pain network. Further, they demonstrated the importance of two enzymes that make phospholipids, by removing those enzymes from mice, making them hypersensitive to heat pain. These results are now published online in the international journal PLOS Genetics.

"Pain affects hundreds of millions of people and is a research field badly in need of new approaches and discoveries," said Dr Neely.

"The fact that evolution has done such a remarkable job of conserving pain genes across species makes our fly data very useful, because much of it translates to rodents and people.

"We are able to test our hypotheses in mice, and if a gene or pathway or process functions as we predict, there is a good chance it will also apply to people.

"B
'/>"/>

Contact: Iris Hui
iris.hui@researchaustralia.org
61-292-958-545
Research Australia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Video-assisted thoracic surgery valuable tool in lung cancer screening
2. Predicting, preventing, and controlling pandemics: Making the case for a strategic action plan
3. Researchers develop non-invasive technique for predicting patients response to chemotherapy
4. Study uncovers simple way of predicting severe pain following breast cancer surgery
5. A new model for predicting recovery after spinal cord injury
6. Predicting post-traumatic stress disorder before it happens
7. Study examines BI-RADS and MRI in predicting breast cancer
8. A relationship between cancer genes and the reprogramming gene SOX2 discovered
9. Patients with aberrations in two genes respond better to drugs blocking a well-known cancer pathway
10. 1000 genomes study is guidebook to how genes vary
11. New findings on mens genes could alter interpretation of PSA test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... York (PRWEB) , ... September 01, 2015 , ... Zecurion, ... Zlock Mac , its groundbreaking new version of endpoint DLP developed specifically for Mac ... Mac, in which more than 100 IT and information security professionals had participated. The ...
(Date:9/1/2015)... ... September 01, 2015 , ... Two of Washington D.C.’s most respected chefs ... and dining. , Recently named “the next big thing” in the culinary world ... telling the whole story behind food and reclaiming culinary traditions on the brink of ...
(Date:9/1/2015)... ... 2015 , ... METTLER TOLEDO has announced an upcoming webinar ... , featuring Ed Szczesny (Quality Assurance, Rhodes Pharmaceuticals) as guest presenter. This webinar ... , Calibration, qualification, and the appropriate level of routine testing for laboratory instruments ...
(Date:9/1/2015)... ... , ... Mercy Health (formerly Catholic Health Partners) – a Catholic healthcare ministry ... Helping You Be Well videos to prostate cancer awareness. Prostate cancer is the most-common, ... video on Mercy Health’s YouTube channel, Mercy Health experts address issues, such as:, ...
(Date:9/1/2015)... , ... September 01, 2015 , ... ... 9, 2015 from 5:00 to 8:00 pm at the Marriott Indianapolis Downtown, 350 ... with career opportunities will be attending from across the country. All specialties will ...
Breaking Medicine News(10 mins):Health News:Zecurion Announces Endpoint Security for Mac 2Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 2Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 4Health News:Live Webinar from Pharmaceutical Technology and METTLER TOLEDO on Calibration and Qualification of Laboratory Instruments 2Health News:New Mercy Health Video Explains Most-Common Cancer Found in Men 2Health News:PracticeMatch to Host Physician Career Fair at the Marriott Indianapolis Downtown on September 9, 2015 2Health News:PracticeMatch to Host Physician Career Fair at the Marriott Indianapolis Downtown on September 9, 2015 3Health News:PracticeMatch to Host Physician Career Fair at the Marriott Indianapolis Downtown on September 9, 2015 4
... brain responsible for imitation may be behind the unique ... searching for roots of empathy have now found brain ... also identified a network of brain regions that are ... enable a person to distinguish the self from others.The ...
... conduct tests for any Indian doctor having graduated abroad avid ... higher standards amongst doctors, the government has made it compulsory ... today. , The new regulations, ... students who want to enrol in MBBS course abroad will ...
... Four people are confirmed dead from pneumonic plague in ... plague from a remote village of Himachal Pradesh state ... // ,"The sequence of tests collectively confirmed that ... known as pneumonic plague," Federal Health Minister C.P. Thakur ...
... many people trying to lose weight are not using the right ... cent of men and 50 per cent of women said ... to lose weight or at least not gain any more. ... and one fourth of those keeping their weight stable were using ...
... By the use of novel scanning methods doctors have found that ... brain. It is the section that governs the body clock, which ... ,Cluster headaches are marked by a sudden tormenting pain on one ... can last for 20 minutes to 3 hours. Affecting 0.1% of ...
... and vitamins increased the exercise capacity and quality of life ... can produce the gas nitric oxide which, in turn, may ... that arginine might help people with heart problems, especially those ... ,In fact the validation for arginine supplements so far ...
Cached Medicine News:Health News:The brain wave 2
(Date:9/1/2015)... 1, 2015 The global ... basis of sectors, products & services and application. And ... with the increasing demand of advanced drugs for ... propel the growth for bioinformatics market. The implementation ... is known as bioinformatics. Decreasing cost of DNA ...
(Date:9/1/2015)... DUBLIN , Aug. 31, 2015 ... the addition of the "Introduction to Veterinary ... to their offering. This course ... a good introduction to those concerned with Veterinary ... experienced personnel who reqire a better understanding of ...
(Date:9/1/2015)... , Sept. 1, 2015  Abbott (NYSE: ABT ... a multi-center, randomized trial comparing the safety and effectiveness ... ® , Abbott,s market-leading, permanent drug eluting stent. ... Japan and enrolled 400 people with ... disease. The results will be featured at a late-breaking ...
Breaking Medicine Technology:Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 2Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 3Global Bioinformatics Market Valued at Over $1.3 Billion in 2013 and is Expected to Grow at CAGR of 20.3% From 2014 to 2020: Hexa Research 4Introduction to Veterinary Pharmacovigilance Seminar (London, UK - September 23-24) 2Abbott Announces Positive Results of Its Naturally Dissolving Stent from ABSORB Japan Study 2Abbott Announces Positive Results of Its Naturally Dissolving Stent from ABSORB Japan Study 3Abbott Announces Positive Results of Its Naturally Dissolving Stent from ABSORB Japan Study 4
... has released an updated AutoLabel solution with enhanced customized ... virtually 100% of medications have a scan-ready bar code ... AutoLabel is a complete barcoding solution that provides color-coded ... improve patient safety at the bedside. New features include ...
... ("CTI") (NASDAQ and MTA: CTIC) announced that final results ... relapsed or refractory acute myeloid leukemia ("AML") was selected ... of Hematology ("ASH") Annual Meeting, which will be held ... Jorge Cortes, M.D., of The University of ...
Cached Medicine Technology:Talyst Updates Its AutoLabel® Solution 2Tosedostat OPAL Study Final Results Selected for Oral Presentation at the 2011 American Society of Hematology (ASH) Annual Meeting 2Tosedostat OPAL Study Final Results Selected for Oral Presentation at the 2011 American Society of Hematology (ASH) Annual Meeting 3Tosedostat OPAL Study Final Results Selected for Oral Presentation at the 2011 American Society of Hematology (ASH) Annual Meeting 4
... ergonomic chairs with concave seats ... support • Select options like ... and glides. • BTT/1P chairs ... environments: industry, education, laboratory, clean ...
... with concave seats and standard-sized ... Select options like seats, backrests, ... • BTT/1P chairs are recommended ... education, laboratory, clean room, static ...
... chairs with concave seats and large ... options like seats, backrests, armrests, and ... BE Series for top performance in ... education, laboratory, clean room, static control, ...
... ergonomic chairs with concave seats and ... Select options like seats, backrests, armrests, ... the BE Series for top performance ... industry, education, laboratory, clean room, static ...
Medicine Products: