Navigation Links
Valuable tool for predicting pain genes in people
Date:12/6/2012

Scientists in Australia and Austria have described a "network map" of genes involved in pain perception, with remarkable similarity from fruit flies to people. The work should help identify new analgesic drugs.

Dr Greg Neely from the Garvan institute of Medical Research in Sydney and Professor Josef Penninger from the Austrian Academy of Sciences in Vienna had previously screened the 14,000 genes in the fly genome and identified 580 genes identified with heat perception. In the current study, using a database from the US National Centre for Biotechnology Information, they noted roughly 400 equivalent genes in people, 35% of which are already suspected to be pain genes.

The map they constructed using fly and human data includes many known genes, as well as hundreds of new genes and pathways, and demonstrates exceptional evolutionary conservation of molecular mechanisms across species. This should not be surprising, as any creature must be able to identify a source of pain or danger in order to survive.

Comparing fly with human data, they could see that a particular kind of molecular signaling (phospholipid signaling), already implicated in pain processing, appeared in the pain network. Further, they demonstrated the importance of two enzymes that make phospholipids, by removing those enzymes from mice, making them hypersensitive to heat pain. These results are now published online in the international journal PLOS Genetics.

"Pain affects hundreds of millions of people and is a research field badly in need of new approaches and discoveries," said Dr Neely.

"The fact that evolution has done such a remarkable job of conserving pain genes across species makes our fly data very useful, because much of it translates to rodents and people.

"We are able to test our hypotheses in mice, and if a gene or pathway or process functions as we predict, there is a good chance it will also apply to people.

"By cross-referencing fly data with human information already in the public domain like gene expression profiling or genetic association studies we know we'll be able to pinpoint new therapeutic targets."


'/>"/>

Contact: Iris Hui
iris.hui@researchaustralia.org
61-292-958-545
Research Australia
Source:Eurekalert

Related medicine news :

1. Video-assisted thoracic surgery valuable tool in lung cancer screening
2. Predicting, preventing, and controlling pandemics: Making the case for a strategic action plan
3. Researchers develop non-invasive technique for predicting patients response to chemotherapy
4. Study uncovers simple way of predicting severe pain following breast cancer surgery
5. A new model for predicting recovery after spinal cord injury
6. Predicting post-traumatic stress disorder before it happens
7. Study examines BI-RADS and MRI in predicting breast cancer
8. A relationship between cancer genes and the reprogramming gene SOX2 discovered
9. Patients with aberrations in two genes respond better to drugs blocking a well-known cancer pathway
10. 1000 genomes study is guidebook to how genes vary
11. New findings on mens genes could alter interpretation of PSA test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... 2016 , ... US Sports Camps has collaborated with State Rugby Organization (SRO), ... this summer. Employing world-class rugby figures, including former Team USA players and college coaches, ... key fundamentals, match play, fitness and more. , “US Sports Camps is honored to ...
(Date:5/6/2016)... ... 2016 , ... Innovations with Ed Begley Jr. announced today ... via Discovery Channel. Dates and show times TBA. , AsedaSciences® was established in ... innovative cellular analysis. In this segment, viewers will learn how AsedaSciences utilizes flow ...
(Date:5/6/2016)... ... May 06, 2016 , ... Online HR/benefits platforms offer a ... the game for traditional brokers and health plans. “ The Rapid Emergence of Online ... from Atlantic Information Services, Inc. (AIS), will offer an accurate picture of online benefits ...
(Date:5/6/2016)... ... ... Mark Black is a speaker, author, and life strategy coach who is spreading ... the help of his publisher Strategic Book Group and its subsidiary Publish on Demand ... for a miracle: He needed a heart and double-lung transplant. From this came a life-changing ...
(Date:5/6/2016)... , ... May 06, 2016 , ... Multiple award winning ... family-owned and operated for over 35 years. Maintaining core values of exceptional customer service, ... success and made them a leading name in San Diego plumbing, and other services ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... JERUSALEM , May 4, 2016 ... University of Jerusalem announced today that it had ... BioTheryX, Inc. , developer of novel protein degradation ... the development and commercialization of drug candidates representing first-in-class ... the license were not disclosed. The novel ...
(Date:5/4/2016)... May 4, 2016 ... the  "Global Acute Ischemic Stroke Market and ... their offering.       (Logo: ... Acute Ischemic Stroke Market and Competitive Landscape ... Ischemic Stroke pipeline products, Acute Ischemic Stroke ...
(Date:5/3/2016)... 2016 Global Insulin Needles ... 09 key companies and supported with 272 tables ... study on the current state of the Insulin ... industry including definitions, classifications, applications and industry chain ... for the international market including development history, competitive ...
Breaking Medicine Technology: