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Vall d’Hebron, VHIO and SOLTI head up an international 'dream team' against breast cancer
Date:9/19/2012

ent sample ever used, presents some encouraging findings with regard to the control time of the disease in metastatic patients," explains Dr Cristina Saura, the study coordinator in Spain as a member of SOLTI.

Innovations in breast cancer treatment

The PI3K pathway regulates key cellular functions such as cell growth, proliferation and survival. The appearance of mutations in this pathway is common and seems to contribute to the development of certain types of cancer in women, such as cancers of the breast, ovaries, uterus and endometrium. These mutations have also been implicated in the resistance mechanisms to certain conventional treatments (chemotherapy, hormone treatment or Trastuzumab).

The study that is already underway and open at the Vall d'Hebron University Hospital is a Phase II trial with a specific PI3K pathway inhibitor the molecule BKM120 and "the trial aims to determine the clinical activity of the molecule in patients with triple-negative metastatic breast cancer at an advanced stage of the disease still progressing following treatment with chemotherapy," comments Dr Javier Corts, the Head of the Breast Cancer Unit, and continues, "we are thus talking about advanced disease treatment, when the tumour has progressed to standard treatment options".

One of the novel aspects of this project is that it has been specifically designed to determine, by an analysis of the genetic profiles of patients, whether there is an identifiable subgroup of patients that particularly responds to this treatment. "The analysis of the genetic profiles of patients who respond and those who don't will help us to understand the reasons for this response, thanks to the technology and specialist knowledge that only this Dream Team possesses, which gives it a unique value," explains Dr Rodn, Head of the UITM and principal researcher of this international study.

The study with BKM120 is an example of how the highest level of tec
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Contact: Amanda Wren
34-695-207-886
Vall dHebron Institute of Oncology
Source:Eurekalert

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