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Vall d’Hebron, VHIO and SOLTI head up an international 'dream team' against breast cancer
Date:9/19/2012

Barcelona, 19 September 2012. The Vall d'Hebron Breast Cancer Unit, the Vall d'Hebron Institute of Oncology (VHIO) and SOLTI, an academic breast cancer research group , are heading up a multi-centre international study involving four Spanish and three North American research centres*. The aim of the study is to investigate whether BKM120, a drug that inhibits the PI3K pathway (phosphatidylinositol-3-Kinase) can be an effective treatment against triple-negative breast cancer.

At present it is known that breast cancer can be classified into different subtypes with varying prognoses and responses to treatment. This classification is essentially based on the presence of hormone receptors (oestrogen and progesterone) and the HER2 receptor. In clinical practice this has led to the development of increasingly selective and optimal treatments for patients. Advances in breast cancer treatment using new drugs on accurately-selected populations, along with the implementation of public screening programs, have contributed in recent years to reducing mortality from this disease.

Triple-negative breast cancer: the most aggressive form

Triple-negative breast cancer is defined by the absence of hormone receptors and HER2. This type of breast cancer is an aggressive variety of the disease that generally appears in younger women. Few treatment options beyond chemotherapy and anti-angiogenic agents are currently available. The present study aims to test whether BKM120 is effective for these patients and also, by means of biomarkers in the blood or in the tumour, identify which tumours respond to this new treatment.

The design initiative for this study falls within the grant awarded by the organization Stand Up to Cancer (SU2C), a non-profit entity whose objectives include supporting translational cancer research to ensure that the benefits of the most innovative treatments resulting from basic research can rapidly reach patients through study
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Contact: Amanda Wren
34-695-207-886
Vall dHebron Institute of Oncology
Source:Eurekalert

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