Navigation Links
Validation of salivary-biomarkers for Sjogren's syndrome detection in US population

San Diego, Calif., USA Saturday, March 19, during the 89th General Session & Exhibition of the International Association for Dental Research, held in conjunction with the 40th Annual Meeting of the American Association for Dental Research and the 35th Annual Meeting of the Canadian Association for Dental Research, lead researcher A.N.M. Nazmul-Hossaini will hold an oral presentation on a study titled "Validation of Salivary-Biomarkers for Sjgren's Syndrome Detection in US Population." Recently, a panel of discriminatory salivary transcriptomic and proteomic biomarkers were discovered and validated in an European cohort of primary Sjgren's syndrome (pSS) patients. Afterward, the US study was established under the objective of expanding the clinical utility of the salivary biomarkers by evaluation in an independent cohort of US Sjgren's Syndrome patients.

In the study, researchers collected unstimulated whole saliva samples from 30 well-characterized pSS patients, 30 patients with clinically-diagnosed rheumatoid arthritis (RA) and 30 healthy subjects. The saliva levels of 10 pSS mRNA markers were quantified by qRT-PCR. The levels of three salivary pSS protein markers (B2M, SSS and SSB) were quantified by Enzyme-Linked Immunosorbent Assay. Group differences of expression levels were tested by t-test. A logistic regression model was built and receiver operating characteristic (ROC) curves were constructed to determine the diagnostic capabilities of the respective salivary biomarkers.

At the conclusion of the study, a panel of 3 salivary mRNA biomarkers (B2M, GIP2 and MNDA) and 3 protein biomarkers (B2M, SSA and SSB) were validated in both European and US population cohorts, thus permitting the translational and clinical utilization of these biomarkers in a non-invasive manner for real-time cost effective clinical applications. Supported by NIH/NIDCR Grant: R01-DE017593.


Contact: Ingrid L. Thomas
International & American Association for Dental Research

Page: 1

Related medicine news :

1. Reports claiming ALS caused by head trauma lacks scientific validation
2. dbMaestro Achieves “Ready For IBM Rational Software” Validation For Rational Team Concert Integration
3. "IPGDx, LLC Announces The Continued Validation Of Its Patented Technology For The Assessment Of Prognosis; PrognostiCheck" Getting the New Information to Patients and Do
4. Amistaff Launches RN Medical/Surgical & RN Pharmacology Exams Using New Validation Process Focused on Improving Quality of Patient Care
5. The European Medicines Agency Completes Validation Stage for InterMunes Marketing Authorization Application for pirfenidone
6. Home Dialysis for Kidney Patients May Ease Restless Legs Syndrome
7. Shar-Pei Dogs Shed Light on Human Fever Syndromes
8. Potential new treatment to reduce the burden of atherosclerosis in acute coronary syndrome patients
9. Mediterranean Diet Reduces Risk of Metabolic Syndrome
10. In Shaken Baby Syndrome, Women as Likely to be Perpetrators as Men: Study
11. Noninvasive Test May Identify Down Syndrome Early On
Post Your Comments:
(Date:6/24/2016)... ... , ... June 19, 2016 is World Sickle Cell Observance Day. In an ... of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a ... Cell Disease (SCD) is a disorder of the red blood cells, which can cause ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the ... in the world, and the most handsome men, look naturally attractive. Plastic surgery ...
(Date:6/24/2016)... ... 2016 , ... National recruitment firm Slone Partners is pleased to ... genomics experience, as Vice President of North American Capital Sales at HTG Molecular ... the sales team in the commercialization of the HTG EdgeSeq system and associated reagents ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... , , , WHEN: , , ... , , , LOCATION: , , , Online, with free registration ... PANELISTS:  , , , Frost & Sullivan,s Global Vice President of ... Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... witnessing an exceptional era. Several new demand spaces, such as innovative ...
Breaking Medicine Technology: