Navigation Links
Validation of salivary-biomarkers for Sjogren's syndrome detection in US population
Date:3/18/2011

San Diego, Calif., USA Saturday, March 19, during the 89th General Session & Exhibition of the International Association for Dental Research, held in conjunction with the 40th Annual Meeting of the American Association for Dental Research and the 35th Annual Meeting of the Canadian Association for Dental Research, lead researcher A.N.M. Nazmul-Hossaini will hold an oral presentation on a study titled "Validation of Salivary-Biomarkers for Sjgren's Syndrome Detection in US Population." Recently, a panel of discriminatory salivary transcriptomic and proteomic biomarkers were discovered and validated in an European cohort of primary Sjgren's syndrome (pSS) patients. Afterward, the US study was established under the objective of expanding the clinical utility of the salivary biomarkers by evaluation in an independent cohort of US Sjgren's Syndrome patients.

In the study, researchers collected unstimulated whole saliva samples from 30 well-characterized pSS patients, 30 patients with clinically-diagnosed rheumatoid arthritis (RA) and 30 healthy subjects. The saliva levels of 10 pSS mRNA markers were quantified by qRT-PCR. The levels of three salivary pSS protein markers (B2M, SSS and SSB) were quantified by Enzyme-Linked Immunosorbent Assay. Group differences of expression levels were tested by t-test. A logistic regression model was built and receiver operating characteristic (ROC) curves were constructed to determine the diagnostic capabilities of the respective salivary biomarkers.

At the conclusion of the study, a panel of 3 salivary mRNA biomarkers (B2M, GIP2 and MNDA) and 3 protein biomarkers (B2M, SSA and SSB) were validated in both European and US population cohorts, thus permitting the translational and clinical utilization of these biomarkers in a non-invasive manner for real-time cost effective clinical applications. Supported by NIH/NIDCR Grant: R01-DE017593.


'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
703-299-8084
International & American Association for Dental Research
Source:Eurekalert

Page: 1

Related medicine news :

1. Reports claiming ALS caused by head trauma lacks scientific validation
2. dbMaestro Achieves “Ready For IBM Rational Software” Validation For Rational Team Concert Integration
3. "IPGDx, LLC Announces The Continued Validation Of Its Patented Technology For The Assessment Of Prognosis; PrognostiCheck" Getting the New Information to Patients and Do
4. Amistaff Launches RN Medical/Surgical & RN Pharmacology Exams Using New Validation Process Focused on Improving Quality of Patient Care
5. The European Medicines Agency Completes Validation Stage for InterMunes Marketing Authorization Application for pirfenidone
6. Home Dialysis for Kidney Patients May Ease Restless Legs Syndrome
7. Shar-Pei Dogs Shed Light on Human Fever Syndromes
8. Potential new treatment to reduce the burden of atherosclerosis in acute coronary syndrome patients
9. Mediterranean Diet Reduces Risk of Metabolic Syndrome
10. In Shaken Baby Syndrome, Women as Likely to be Perpetrators as Men: Study
11. Noninvasive Test May Identify Down Syndrome Early On
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... LA (PRWEB) , ... October 12, 2017 , ... Planet ... in the U.S., announced today its plans to open a flagship location in Covington, ... occupy the former Rooms To Go store next to Office Depot in the Holiday ...
(Date:10/12/2017)... ... 12, 2017 , ... Asante, a nationally recognized health system ... their existing home health joint venture through an agreement, effective October 1, 2017, ... venture home health company with Asante, delivering clinically integrated care, for the past ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... SAN DIEGO , Oct. 12, 2017   Divoti ... Medical Alert Jewelry up to the standard of the latest FDA ... (Launched: June 2017). Anyone in need of Medical ID ... Divoti Medical Alert Jewelry are engraved in terms of the ... ...
(Date:10/11/2017)... , Oct. 11, 2017  True Health, a ... amplified its effort during National Breast Cancer Awareness ... cancer risks. ... Oncology calculated that more than 10 million American ... mutations in BRCA1 or BRCA2 and have not had ...
(Date:10/7/2017)... Oct. 6, 2017   Provista, a proven ... $100 billion in purchasing power, today announced a new ... The Newsroom is the online home for ... infographics, expert bios, news releases, slideshows and events. ... a wealth of resources at their fingertips, viewers can ...
Breaking Medicine Technology: