Navigation Links
Vaginal delivery as safe as cesarean for most early preterm births
Date:8/6/2012

Philadelphia, PA, August 6, 2012 Vaginal delivery for early preterm fetuses presenting head first, or vertex presentation, had a high rate of success with no difference in neonatal mortality compared to cesarean delivery, a new study published in the American Journal of Obstetrics and Gynecology reports. For breech births, however, the failure rate of vaginal delivery was high and planned cesarean delivery was associated with significantly lower neonatal mortality.

"Selecting a route of delivery at less than 32 weeks' gestation is a difficult clinical decision given the high rate of infant mortality and morbidity as well as the maternal risks associated with cesarean delivery," says lead investigator Uma M. Reddy, MD, MPH, of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. "For vertex-presenting fetuses less than 32 weeks' gestation, we saw no improvement in neonatal mortality with a planned cesarean delivery."

Trials that attempt to randomize the route of delivery for women in preterm labor at high risk for delivery have not been feasible. Dr. Reddy and her colleagues used data from the Consortium on Safe Labor (CSL), a study conducted by the Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health. The CSL is a retrospective study collecting extensive data on over 200,000 deliveries between 2002 and 2008 from 12 clinical centers and 19 hospitals across the country.

The investigators first categorized the indications for preterm delivery: preterm labor, preterm premature rupture of membranes (PPROM), or fetal/maternal issues such as preeclampsia, placental abruption, or severe maternal medical disease. Maternal or fetal indications were responsible for 45.7% of early preterm deliveries, PPROM for 37.7%, and preterm labor for 16.6%. Preeclampsia and major congenital anomalies were the leading contributors to indicated early preterm births. The study then evaluated 2,906 singleton pregnancies between 24 0/7 weeks and 31 6/7 weeks eligible for either route of delivery. Attempted vaginal delivery was compared to planned cesarean delivery. Data were analyzed based on gestational age blocks: 24 0/7 to 27 6/7 weeks and 28 0/8 to 31 67 weeks, based on the fact that the highest rates of neonatal mortality and morbidity occur 24 0/7 to 27 6/7 weeks.

Attempting vaginal delivery with vertex presentation at 24 0/7 to 27 6/7 weeks of gestation did not significantly affect neonatal mortality. More than 80% of the attempted vaginal births were successful. However, if the fetal presentation was breech, the majority of the deliveries were by planned cesarean delivery, and only 27.6% of attempted vaginal deliveries were successful.

Findings in the 28 0/7 to 31 6/7 weeks' gestation also differed by presentation. If the fetal presentation was vertex, the majority of attempted vaginal deliveries succeeded and there was no difference in the neonatal mortality rate compared with planned cesarean delivery. For breech-presenting fetuses, neonatal mortality was 6% for vaginal deliveries compared to 1.5% of the cesarean deliveries.

Dr. Reddy notes that previous studies examining the effect of route of delivery on neonatal mortality for early preterm births looked at the actual, not attempted, route of delivery. "The detailed information in our study, not available in birth certificate data, enabled us to account for the effect of attempted route of delivery and indications for delivery on neonatal mortality. This information has direct clinical applications and is crucial for counseling families about the benefit and risks of attempting vaginal delivery in this situation," she concludes.


'/>"/>
Contact: Francesca Costanzo
ajogmedia@elsevier.com
215-239-3249
Elsevier Health Sciences
Source:Eurekalert

Related medicine news :

1. Johnson & Johnson Violated FDA Order to Halt Sales of Transvaginal Mesh
2. US Drug Watchdog Launches Now Calls Transvaginal Mesh A Disaster For 100,000's of US Women Recipients And Offers The Names and Contacts Of The Best Women Attorneys
3. Internists express support for new payment and delivery models as basis for replacing SGR
4. Popularity Causing Several Week Lag In Delivery Of 'Plug In' Device To Start Saving On Electricity Between 8% and 20%
5. New delivery method improves efficacy of 2 common Parkinsons disease medications
6. UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery
7. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
8. Early treatment could mean greater earning potential for people with HIV
9. Scientists looking for noninvasive ways to detect lung cancer early
10. All HIV Patients Should Take Meds Early On, Experts Now Say
11. Dads Early Engagement With Son May Shape Behavior Later
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... ... March 27, 2017 , ... Sodium determination is consistently becoming ... require expert user knowledge. In a live webinar on April 11th and October ... highly accurate, determination of sodium. , It has long been known that too ...
(Date:3/27/2017)... CA (PRWEB) , ... March 27, 2017 , ... ... has entered a settlement agreement to resolve the pending litigation between itself and ... for the District of Utah). , “I am thrilled to announce that we ...
(Date:3/27/2017)... RICHEY, Fla. (PRWEB) , ... March 27, 2017 ... ... drug overdose deaths soared 167%,(1) with opioids alone responsible for over 33,000 of ... Kevin McCarty has sponsored Assembly Bill (AB) 1512, which proposes a tax on ...
(Date:3/27/2017)... ... , ... Harris Communications, Inc., a leading provider of assistive technology for ... Deaf Seniors of America Conference, April 4-7 at the Hotel Westin Galleria in Houston. ... staff from Harris Communications and to try out the newest assistive devices available to ...
(Date:3/25/2017)... ... March 25, 2017 , ... Getting earned media coverage meaningful for Garden Media ... All through the year, Garden Media aims to provide material helpful to clients’ goals ... pitching client’s key messages to gain coveted media placements, Garden Media wows ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... Therapix Biosciences Ltd. (NASDAQ: ... the development of cannabinoid-based drugs, today announced the ... the United States of 2,000,000 American ... shares of the Company, at a price of ... the underwriters a 45-day over-allotment option to purchase ...
(Date:3/27/2017)... March 27, 2017  A recent study at Shriners ... freestanding hospitals in the country dedicated to the treatment ... surgery, concluded that the Surfacide Helios ® UV-C ... in reducing bacterial pathogens not killed by the EVS ... at the American Burn Association,s 49th Annual Meeting in ...
(Date:3/27/2017)... March 27, 2017  ImMAGE Biotherapeutics (OTCMKTS: IMMG), an ... passed early toxicology and efficacy studies. The company is ... a specific protein, MAGE A, in an effort to ... After 4 weeks of treatment in ... very little toxicity in a full toxicology report of ...
Breaking Medicine Technology: