Navigation Links
Vaginal Microbicides Might Help More Men Than Women
Date:7/10/2008

Researchers say clinical trials' design may also mask risk of HIV drug resistance

THURSDAY, July 10 ( HealthDay News) -- A new study questions whether vaginal microbicides being developed to help protect women against HIV infection could lead to new drug resistance from the virus that causes AIDS.

The study, published July 7 in the online issue of Proceedings of the National Academy of Sciences, also shows that, under certain circumstances, men may actually benefit a bit more than women from the microbicides, which are compounds that can be applied inside the vagina.

Drug companies are running clinical trials on some second-generation microbicides based on antiretroviral, or ARV, medicines.

The study by the UCLA AIDS Institute also questions the designs of these trials. The researchers made the conclusions by using mathematical models that simulate clinical trials and population-level transmission of HIV.

Under the scenarios the researchers developed, men were slightly more protected than woman in certain situations. This occurred when the in-trial microbicide, an ARV drug called dapivirine, was only effective about half the time in women -- a situation that could occur if HIV-positive women on microbicides developed drug-resistant strains of HIV that were then less likely to be transmitted to men.

"The antiretroviral drugs within these microbicides are the same as those used to treat people who are infected with HIV, so there is great expectation that these microbicides will be very effective," said first author Dr. David Wilson, of the National Centre in HIV Epidemiology and Clinical Research at Australia's University of New South Wales, in a prepared statement.

"But the concern is that these microbicides are going to lead to drug resistance," he said.

Concerns about drug resistance come from the fact that the current clinical trial drops women from the study if they turn up HIV-positive during monthly screening, the researchers said.

"Since monthly testing will take place in the dapivirine trial, we predict that few, if any, cases of acquired resistance will arise during the trial, even if the drug is readily absorbed (i.e., the microbicide is high risk)," the researchers wrote. "Therefore, our analyses have shown that high-risk microbicides could pass Phase III trials, as their potential to cause resistance will be masked by frequent testing."

More information

The U.S. Department of Health & Human Services has more about HIV prevention drugs.



-- Kevin McKeever



SOURCE: University of California, Los Angeles, news release, July 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. HIV prevention researchers to compare common ARV as a pill and vaginal gel in unique study
2. Study Finds More Than One in Two Women are Too Embarrassed to Discuss Vaginal Discomfort With Their Doctors
3. IPM Reaches Landmark Agreement with Pfizer to Develop FDA-Approved Antiretroviral Drug as Vaginal Microbicide
4. Antiretroviral Drugs May Prevent Vaginal Transmission of HIV
5. Vaginal progesterone gel may improve infant outcomes and...
6. Researchers develop new tool to predict who will use microbicides
7. ADHD Might Raise Kids Obesity Risk
8. Meditation, Yoga Might Switch Off Stress Genes
9. Could new discovery about a shape-shifting protein lead to a mighty morpheein bacteria fighter?
10. Stem Cells Might Treat Tough Fractures
11. Diabetes Might Help Spur Hearing Loss
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vaginal Microbicides Might Help More Men Than Women
(Date:2/11/2016)... ... February 11, 2016 , ... The book, “Computers Should Just Work!”, provides a ... ask your IT consultant before signing a contract and how to spot an incompetent ... companies relying heavily on e-mail and technology, it’s more important than ever to make ...
(Date:2/10/2016)... ... February 10, 2016 , ... President Obama’s ... Advantage organizations to deliver medical services via telehealth, estimated to generate more than ... for such language for many years. Although there is more to be ...
(Date:2/10/2016)... ... 10, 2016 , ... Early this week, Team Iconic at J. Walter Thompson ... as the first global confectionery brand sourced from 100% sustainable cocoa. , The Nestlé ... their product, through activities that focus on better farming, better lives and better cocoa. ...
(Date:2/10/2016)... ... 10, 2016 , ... Western University of Health Sciences and ... developmentally disabled in the Coachella Valley. , The two entities, through an expanded ... Highway 111, Suite 100-B, in Rancho Mirage, California. The new site has 11 ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... (VRI) within Healthcare, recently partnered with Heart City Health Center to ... nearly 23 years, Heart City Health Center has provided the Elkhart community with ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... February 11, 2016 ... the "Molecular Diagnostics Reports Bundle" ... http://www.researchandmarkets.com/research/rp4pg8/molecular ) has announced the addition of ... report to their offering. --> ... announced the addition of the "Molecular ...
(Date:2/10/2016)... SUNNYVALE, Calif. , Feb. 10, 2016 /PRNewswire/ ... Warren Kocmond , formerly Executive Vice President ... the position of President and Chief Operating Officer.  ... been expanded, and now include Global Commercial Operations ... and Customer Service.  Mr. Kocmond will continue to ...
(Date:2/10/2016)... , February 10, 2016 --> --> ... Japan .  --> Japan .  --> A ... With submission, Shire continues to strengthen ... With submission, Shire continues to strengthen its presence ... submission, Shire continues to strengthen its presence ...
Breaking Medicine Technology: