Navigation Links
Vaccines for Ovarian and Breast Cancer in Early Trials
Date:1/11/2008

Activating body's immune system should fight tumors, researchers say

FRIDAY, Jan. 11 (HealthDay News) -- Therapeutic vaccines to fight ovarian and breast cancer are in the first stage of clinical trials to determine their safety and effectiveness, researchers report.

The vaccine for ovarian cancer, developed by Dr. George Coukos, an assistant professor at the University of Pennsylvania's division of gynecologic oncology, is designed to "re-educate" the patient's immune system cells to destroy cancer cells.

"This trial is a phase I/II trial that is just getting started," Coukos said during a presentation Thursday evening at a meeting of the Alliance for Cancer Gene Therapy, in Greenwich, Conn. The trial will include some 30 women with ovarian cancer.

The vaccine makes use of the patients' own tumor cells, which are then put into the patients' own dendritic cells. Dendritic cells are responsible for initiating the body's immune response, Coukos said.

In this trial, two new drugs -- called DCVax-L and DCVax-L primed -- are being used to aid in growing new immune cells. The trial is also testing which of the drugs is most effective.

The "re-educated" dendritic cells are then injected back into the patient at intervals spanning as long as three years, according to Coukos. Once in the body, these cell are designed to attack the cancer cells.

Using this therapy in mice produced dramatic results, Coukos said. "Typically, the translation from mouse to human is always disappointing," he said. "We are hoping, based on other clinical data, there will be a good response."

By creating individualized ovarian cancer vaccines composed of a patient's own cells, Coukos believes that his tailored approach will be effective. "We actually use the patient's own tumor and the patient's own blood. So it's not one-type-of-therapy-fits-all. Everybody gets their own individualized treatment," he said.
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Human Papilloma Virus vaccines may decrease chances of oral cancer
2. CDC Study Links Thimerosal in Vaccines to Motor/Phonic Tics and Deficits in Attention, Behavior Control, Verbal IQ
3. Novartis Vaccines Launches National Gift-Giving Program to Help Protect Loved Ones by Reserving an Influenza Vaccination
4. Combination vaccines okay for infants, study shows
5. Colorado Influenza and Pneumococcal Alert Coalition (CIPAC) Partners with Novartis Vaccines for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers
6. Novartis Vaccines Partners With RediClinic for Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers
7. Novartis Vaccines to Host Holiday Vaccination Clinic, Making Influenza Vaccination Convenient for Shoppers
8. St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases
9. Study Shows Cholera Can be Controlled With Oral Vaccines
10. Pneumococcal conjugate vaccines can improve the lives of HIV-infected children
11. New study suggests why vaccines directed against cancer, HIV dont work
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vaccines for Ovarian and Breast Cancer in Early Trials
(Date:4/18/2014)... A new study in the American Journal of ... searches reveals a recurring pattern that could be leveraged ... from San Diego State University, the Santa Fe Institute, ... Google searches (searches that included the term healthy and ... U.S. from 2005 to 2012. They found that on ...
(Date:4/17/2014)... who show signs of chronic inflammation in non-cancerous prostate ... having prostate cancer than those with no inflammation, according ... from the Johns Hopkins Kimmel Cancer Center. , The ... for men with so-called high-grade prostate cancer those ... indicating the presence of the most aggressive and rapidly ...
(Date:4/17/2014)... in PLOS Pathogens , children who live in ... mount an immune response to infection with malaria parasites ... high fever and illness and partially control the growth ... help researchers develop future interventions that prevent or mitigate ... year, approximately 200 million cases of malaria occur worldwide, ...
(Date:4/17/2014)... NY In a review published in the April ... president of The Feinstein Institute for Medical Research, says ... medical community,s approach to treating sepsis, which ... Americans. , Sepsis occurs when molecules released into the ... throughout the body. Inflammation is necessary for maintaining good ...
(Date:4/17/2014)... 2014) Doctors who treat patients with a ... can face an agonizing treatment decision. , The ... and help relieve shortness of breath. But some ... can cause potentially fatal complications following transplantation. , ... Dilling, medical director of Loyola University Medical Center,s ...
Breaking Medicine News(10 mins):Health News:New research shows people are thinking about their health early in the week 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3
... by the Seychelles Food and Agriculture Organization (FAO) to ... all the necessary help like donating equipment such as ... Department of Natural resources. This done as they would ... local outbreak. The FAO’s country correspondent, Antoine Marie Moustache ...
... problems of health capturing people worldwide it is very important to ... it is done at the workplace for people who work- almost ... educate the employees on how to attain a better health and ... stay fit and not turn obese. This also helps to cut ...
... MCD today said there was a rise in the breeding ... //a special drive to check breeding of the vector. ... for the spread of the dreaded fever, has been reported ... the Corporation said in a release. ,The MCD ...
... has urged the doctors working in various hospitals in ... vaccine, as recommended by World Health Organisation //. ... intra-dermal route, the doctors could vaccinate five patients from ... per cent less as compared to intra-muscular vaccine. ...
... who stutter, cope with their stressors and emotions as ... with the speech difficulty //. , ,"Our ... apt to be emotionally aroused, less able to settle ... attention and emotion during everyday stressful or challenging situations," ...
... postmortem brain tissue from patients with schizophrenia, researchers at ... with scientists at the City University of New York, ... high level of erbB4 receptor activity and reduced NMDA ... prefrontal cortex of schizophrenic patient were stimulated. Thus found ...
Cached Medicine News:Health News:An analysis of pros and cons of health education at the workplace 2Health News:Supporting children with stress key to improve stuttering 2Health News:Supporting children with stress key to improve stuttering 3Health News:Schizophrenia Complicates With Altered Receptor Activity 2Health News:Schizophrenia Complicates With Altered Receptor Activity 3
(Date:1/15/2014)... Ky. , Jan. 15, 2014  Manufacturers, suppliers ... must be able to protect their most important ... http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ) Because of ... it steadfastly remains one of the most litigious ...
(Date:1/15/2014)... , Jan. 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ... its Symphony® CGM System as a non-invasive, wireless continuous ... Doman , Executive Chairman and Interim CEO of Echo ... Tenth Annual Equity Conference. Mr. Doman ...
(Date:1/15/2014)... 15, 2014 Reportlinker.com announces that a ... its catalogue: PharmaPoint: ... Market Analysis to 2022 ... - India Drug Forecast and Market Analysis ...
Breaking Medicine Technology:Intellectual Property Insurance for Medical-related Products and Services 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: