Navigation Links
Vaccine slows progression of skeletal muscle disorder
Date:5/13/2009

Irvine, Calif., May 13, 2009 A potential vaccine for Alzheimer's disease also has been shown in mice to slow the weakening of muscles associated with inclusion body myositis, a disorder that affects the elderly.

The finding brings new hope for IBM patients with weakness, inflammation or atrophy of muscles in their fingers, wrists, forearms or quadriceps. There is no cure for IBM, nor is there an effective treatment, according to the National Institutes of Health.

"The immunization wasn't a complete fix, but it significantly slowed the deterioration of motor function in our IBM mice," said Frank LaFerla, director of UC Irvine's Institute for Brain Aging and Dementia. "I hope our discovery leads to clinical trials and, eventually, a vaccine for people suffering from or at risk for IBM."

Study results appear Wednesday, May 13, in The Journal of Neuroscience.

LaFerla and assistant project scientist Masashi Kitazawa tested the vaccine on 1-year-old mice with high levels of a protein called beta amyloid in their skeletal muscle tissue a characteristic feature of IBM.

After three months of treatment, the mice were producing antibodies against beta amyloid and had less of the protein in their muscles. Levels of oligomeric beta amyloid a more toxic form also were reduced.

"It appears the antibodies helped remove beta amyloid or blocked its accumulation in muscle cells so they could stay healthy longer," Kitazawa said.

Immunotherapy approaches such as vaccination are being extensively studied for Alzheimer's in humans. In that disease, beta amyloid accumulates in the brain and leads to the creation of senile plaques, one of two signature Alzheimer's lesions. Although immunotherapy has shown some benefit in human clinical trials, there are significant safety concerns. For example, about 6 percent of people develop encephalitis, or brain inflammation.

LaFerla thinks it's unlikely IBM patients would develop encephalitis: "With IBM, brain integrity is not compromised like it is with Alzheimer's. We should be cautious, but there's little reason to assume IBM patients would have the same problem."


'/>"/>

Contact: Jennifer Fitzenberger
jfitzen@uci.edu
949-824-3969
University of California - Irvine
Source:Eurekalert

Related medicine news :

1. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
2. HPV vaccine does not appear to be effective for treating pre-existing HPV infection
3. Vaccine Stops Alzheimers Brain Tangles
4. Human Papilloma Virus vaccines may decrease chances of oral cancer
5. U.S. Teens Fall Short on Vaccine Coverage
6. Nasal Anthrax Vaccine Proves Effective in Animal Study
7. Hot ice, measuring depression, perfect invisibility and flu vaccine incentives
8. Bioniche Receives $2 Million Government Grant For Market Development Related to its E. coli O157:H7 Cattle Vaccine
9. Iomai Patch-Based Vaccine Cut Rate of Travelers Diarrhea by 75 Percent in Phase 2 Field Study
10. FDA approves expanded label for FluMist (influenza virus vaccine live, intranasal) to include childr
11. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Coco Libre, ... participation in Red Carpet Events LA GRAMMY’s Style Lounge Event. Coco Libre will offer ... to stay hydrated before the big event. The invitation-only gifting suite, held this year ...
(Date:2/12/2016)... ... February 12, 2016 , ... Itopia, a leader in ... of Clarity Intelligence Platform (CIP) into Cielo®, a discovery, migration and cloud orchestration ... to their small and medium business (SMB) clients. , In recent ...
(Date:2/12/2016)... ... 12, 2016 , ... AssureVest Insurance Group, a locally owned insurance firm with ... will raise funds earmarked to purchase computers and software for Mrs. Harrison’s 2nd and ... is in a low-income area and has more than 60 2nd and 3rd graders ...
(Date:2/12/2016)... ... 2016 , ... Erlanger Agency has announced a new partnership in its ongoing ... focuses on the fight against breast cancer, fundraising for a local woman named Carmen, ... , Carmen is a loving single mother of two boys who also serves as ...
(Date:2/12/2016)... MIAMI, FLA (PRWEB) , ... February 12, 2016 , ... ... free dental implants to their Miami dental office. Beginning in January, Miami Dental ... traditional titanium. Miami Dental Specialists are the first office to be chosen by the ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Feb. 12, 2016  This month,s issue of ... (JMCP) takes an in-depth look at various causes ... in prescription drug spending, which has generated significant public ... Editor-in-Chief Laura E. Happe , PharmD, MPH. ... Happe , PharmD, MPH. --> In 2014 ...
(Date:2/12/2016)... Pharmacy, Inc. (NYSE: DPLO ) is pleased to announce the promotion of Paul ... Jan. 23, 2016. To learn more about ... ... ... In his ...
(Date:2/12/2016)... NY , Feb. 12, 2016 /PRNewswire/ - Demers Ambulances announces ... to Okaloosa County Emergency ... Type III ambulances and one LT2 van. Quality Emergency Vehicles ... dealer, is responsible for the sale.  This is the latest ... LaFortune , Executive Vice President at Demers. --> ...
Breaking Medicine Technology: