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Vaccine shows therapeutic promise against advanced melanoma
Date:6/1/2009

of advanced melanoma," said Schwartzentruber, the study's lead author. "However, we've learned a lot over the last decade, and we need to incorporate these new discoveries as we proceed with our validation of this vaccine."

Schwartzentruber, who with Hwu was involved in the earlier trials and the vaccine's development, will present the findings on ASCO's plenary session on May 30.

Hwu agreed that more research with the vaccine is needed, including long-term follow up of the Phase III patients, as well as researching ways to make the study inclusive of more metastatic melanoma patients.

"Right now, the vaccine only can be given to half of those with melanoma because it has to match a patient's tissue type, or HLA. A major priority for us is to figure out ways to broaden our approach and use mixtures of peptides so that more patients are eligible," Hwu said. "We also would like to improve upon it by including other immune-stimulatory agents, such as anti-CTLA4, an antibody that can take the breaks off the immune cells."


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Contact: Laura Sussman
lsussman@mdanderson.org
832-264-8893
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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