Navigation Links
Vaccine hope for skin cancer sufferers

Nottingham scientists have been given the green light to test a vaccine which they hope could reverse, and even cure malignant melanoma, the most deadly type of skin cancer.

Scancell Holdings plc, led by Professor Lindy Durrant of the University's Division of Clinical Oncology within the School of Molecular Medical Sciences, believes the new vaccine, which targets tumour cells without damaging healthy tissue, could be successful in treating patients with malignant melanoma.

Incidences of malignant melanoma have more than quadrupled over the past 30 years and in the last 25 years rates of malignant melanoma have risen faster than for any other cancer. It is now the most common cancer in younger adults aged 15 to 34, which may be linked to risky associated behaviour such as exposure to the sun on foreign beach holidays and the use of tanning booths. Every year, most of the 2,000 skin cancer deaths result from malignant melanoma.

Professor Durrant said: "Up until now, early diagnosis has been a crucial factor in the successful treatment of this disease. In the early stages it can be cured by completely removing the skin melanoma by surgery. However, in cases where it has not been picked up until further down the line, we have found that chemotherapy and radiotherapy simply do not work, although new compounds are being tested.

"It is still at a very early stage and impossible to predict the outcome of the clinical trial but if our results from the lab are replicated in patients I think we have a good chance of dramatically improving the chances of successful treatment we are hoping that the vaccine will cure between 10 and 20 per cent of patients with malignant melanoma."

Testing for the new SCIB1 vaccine has been given approval by the Gene Therapy Advisory Committee and the Medicines and Healthcare products Regulatory Agency and clinical trials are due to start shortly at Nottingham City Hospital and centres in Manchester and Newcastle.

It will initially be given to patients who are suffering from advanced malignant melanoma which has spread to other parts of the body.

The new vaccine works by activating the body's own natural defence systems it contains DNA and genetic material from tumours meaning it 'switches' on the specific immune cells that target melanoma. This means that it targets only the cancer and not the surrounding healthy tissue.

The team of scientists believe that, in principle, new vaccines based upon the same principle could also be used to target other types of cancer tumours, such as breast and prostate.

Contact: Lindy Durrant
University of Nottingham

Related medicine news :

1. Mount Sinai researchers move closer to a universal influenza vaccine
2. A new cancer vaccine starves tumors of blood
3. Experimental Vaccine Shields Monkeys Against Ebola
4. Smallpox Vaccine May Protect Against HIV
5. Doctors Can Use Rotavirus Vaccine Again: FDA
6. Rotavirus Vaccine Helps Kids Avoid Severe Gastro Illness
7. Study finds rotavirus vaccine greatly reduces hospitalizations for acute gastroenteritis in children
8. Response to vaccines could depend on your sex
9. Misinformation About Vaccine Safety Puts Kids at Risk of Illness
10. New vaccines may come from forcing giardia parasite to display its many disguises
11. Prostate Cancer Vaccine Gains FDA Approval
Post Your Comments:
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic ... many turn to unhealthy avenues, such as drug or alcohol abuse, as a coping ... released tools for healthy coping following a traumatic event. , Trauma sufferers tend to ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Global law ... magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition are ... , Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... feeding the Frederick area economy by obtaining investment capital for emerging technology companies. ... 2½ years that have already resulted in more than a million dollars of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, a ... invasive and more durable cerebrospinal fluid treatments, today ... The Series-A funding is led by Innova Memphis, ... and other private investors.  Arkis, new financing will ... and the market release of its in-licensed Endexo® ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: