Navigation Links
Vaccine for stomach flu may be possible, UNC research shows
Date:2/13/2008

CHAPEL HILL Every year, millions of people are infected with noroviruses - commonly called stomach flu often resulting in up to 72 hours of vomiting and diarrhea. While most people recover in a few days, the symptoms can lead to dehydration and - in rare cases, especially among the elderly and infants - death.

Now, researchers at the University of North Carolina School of Public Health have discovered that the virus mutates genetically, similar to the virus that causes influenza. And, like flu, a vaccine could be possible.

One of the mysteries of medicine has been why do they keep infecting people when youd think wed be developing immunity, said Lisa Lindesmith, one of the lead authors of the study, Mechanisms of GII.4 Norovirus Persistence in Human Populations, published today in the online medical journal PLoS Medicine. What weve found is that the GII.4 arm [of the noroviruses] keeps changing. Whenever were seeing big outbreaks of norovirus, were also seeing genetic changes in the virus.

Noroviruses are the leading cause of viral acute gastroenteritis. They are highly contagious, often causing epidemic outbreaks in families and communities, on cruise ships, in hospitals and in assisted living facilities. The viruses are especially hard on the elderly in 2006, 19 deaths were associated with norovirus acute gastroenteritis in long-term care facilities in the United States. Often, infection can mean many miserable hours, with time lost from work, school and other activities. There is no treatment to stop the infection.

The virus, first isolated from an outbreak in an elementary school in Norwalk, Ohio, in 1968, is common worldwide. The researchers analyzed the relationship among the sequences of certain genes encoding the GII.4 norovirus strains that have been isolated over the past 20 years. They found that the virus evolved irregularly, and when new strains emerged, they often cause epidemic outbreaks.

Authors from UNC include Lindesmith, an epidemiology research specialist in the School of Public Health; Eric Donaldson and Anna LoBue, both doctoral students and research assistants in microbiology and immunology in the UNC School of Medicine; Jennifer Cannon, doctoral student in environmental sciences and engineering; and Ralph Baric, Ph.D., a professor in the School of Public Healths epidemiology department and in the School of Medicines microbiology and immunology department. Authors from the Centers for Disease Control and Prevention include Du-ping Zheng, Ph.D. and Jan Vinje, Ph.D., head of the CDCs National Calicivirus Laboratory.

Noroviruses are very contagious, Lindesmith said. It may only take one or two viral particles to become infected. Good hand washing is critical when the virus is present. A vaccine may someday have an important role, too, especially among the elderly and other people particularly vulnerable to the effects of the illness.


'/>"/>

Contact: Patric Lane
patric_lane@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

Related medicine news :

1. Vaccine Could Cut Bouts With Stomach Flu
2. Iomai Study Shows Self-Applied Travelers Diarrhea Vaccine Patch Comparable to Clinician-Applied Vaccine Patch
3. Meningitis vaccine study gets £200,000 boost
4. Tattooing Best Way to Deliver DNA Vaccines
5. Novel molecules developed at UB can boost vaccine potency
6. USDA Agrees to Grant Conditional License to Bioniche for its E. coli O157:H7 Cattle Vaccine
7. Another Study Finds No Link Between MMR Vaccine and Autism
8. New hospital standards needed for pediatric flu vaccines
9. Experimental Vaccine Halts Prostate Cancer in Mice
10. Novel vaccine concept developed by scientists at the Wistar Institute
11. Mercury in Childhood Vaccines Excreted Quickly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: