Navigation Links
Vaccine for stomach flu may be possible, UNC research shows
Date:2/13/2008

CHAPEL HILL Every year, millions of people are infected with noroviruses - commonly called stomach flu often resulting in up to 72 hours of vomiting and diarrhea. While most people recover in a few days, the symptoms can lead to dehydration and - in rare cases, especially among the elderly and infants - death.

Now, researchers at the University of North Carolina School of Public Health have discovered that the virus mutates genetically, similar to the virus that causes influenza. And, like flu, a vaccine could be possible.

One of the mysteries of medicine has been why do they keep infecting people when youd think wed be developing immunity, said Lisa Lindesmith, one of the lead authors of the study, Mechanisms of GII.4 Norovirus Persistence in Human Populations, published today in the online medical journal PLoS Medicine. What weve found is that the GII.4 arm [of the noroviruses] keeps changing. Whenever were seeing big outbreaks of norovirus, were also seeing genetic changes in the virus.

Noroviruses are the leading cause of viral acute gastroenteritis. They are highly contagious, often causing epidemic outbreaks in families and communities, on cruise ships, in hospitals and in assisted living facilities. The viruses are especially hard on the elderly in 2006, 19 deaths were associated with norovirus acute gastroenteritis in long-term care facilities in the United States. Often, infection can mean many miserable hours, with time lost from work, school and other activities. There is no treatment to stop the infection.

The virus, first isolated from an outbreak in an elementary school in Norwalk, Ohio, in 1968, is common worldwide. The researchers analyzed the relationship among the sequences of certain genes encoding the GII.4 norovirus strains that have been isolated over the past 20 years. They found that the virus evolved irregularly, and when new strains emerged, they often cause epidemic outbreaks.

Authors from UNC include Lindesmith, an epidemiology research specialist in the School of Public Health; Eric Donaldson and Anna LoBue, both doctoral students and research assistants in microbiology and immunology in the UNC School of Medicine; Jennifer Cannon, doctoral student in environmental sciences and engineering; and Ralph Baric, Ph.D., a professor in the School of Public Healths epidemiology department and in the School of Medicines microbiology and immunology department. Authors from the Centers for Disease Control and Prevention include Du-ping Zheng, Ph.D. and Jan Vinje, Ph.D., head of the CDCs National Calicivirus Laboratory.

Noroviruses are very contagious, Lindesmith said. It may only take one or two viral particles to become infected. Good hand washing is critical when the virus is present. A vaccine may someday have an important role, too, especially among the elderly and other people particularly vulnerable to the effects of the illness.


'/>"/>

Contact: Patric Lane
patric_lane@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

Related medicine news :

1. Vaccine Could Cut Bouts With Stomach Flu
2. Iomai Study Shows Self-Applied Travelers Diarrhea Vaccine Patch Comparable to Clinician-Applied Vaccine Patch
3. Meningitis vaccine study gets £200,000 boost
4. Tattooing Best Way to Deliver DNA Vaccines
5. Novel molecules developed at UB can boost vaccine potency
6. USDA Agrees to Grant Conditional License to Bioniche for its E. coli O157:H7 Cattle Vaccine
7. Another Study Finds No Link Between MMR Vaccine and Autism
8. New hospital standards needed for pediatric flu vaccines
9. Experimental Vaccine Halts Prostate Cancer in Mice
10. Novel vaccine concept developed by scientists at the Wistar Institute
11. Mercury in Childhood Vaccines Excreted Quickly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Washington, D.C. (PRWEB) , ... June 25, 2016 ... ... will discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June ... share their work on several important health care topics including advance care planning, ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room ... Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... San Diego, CA (PRWEB) , ... June 24, 2016 , ... ... up with the American Cancer Society and the Road To Recovery® program to drive ... care to seniors and other adults to ensure the highest quality of life and ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 Story Highlights: ... within the health care industry is causing providers to ... , Deloitte offers a suite of solutions for health ... efficient cost optimization: labor resource analysis, revenue cycle optimization ... better outcomes and better economics ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... and Markets has announced the addition of the ... their offering. ... products and provides an updated review, including its applications ... covering the total market, which includes three main industries: ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
Breaking Medicine Technology: