Navigation Links
Vaccine for metastatic breast, ovarian cancer shows promise

PHILADELPHIA Treatment with a recombinant poxviral vaccine showed a positive response in both metastatic breast cancer and ovarian cancer, according to a trial published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

"With this vaccine, we can clearly generate immune responses that lead to clinical responses in some patients," said lead researcher James Gulley, M.D., Ph.D., director and deputy chief of the clinical trials group at the Laboratory of Tumor Immunology and Biology at the National Cancer Institute.

Gulley and colleagues enrolled 26 patients and assigned them to monthly vaccinations with the PANVAC vaccine, which contains transgenes for MUC-1, CEA and three T cell costimulatory molecules.

These patients were already heavily pretreated, with 21 of them receiving at least three prior chemotherapy regimens.

Among the 12 patients with breast cancer, median time to progression was 2.5 months and median overall survival was 13.7 months. Four patients had stable disease.

For the 14 patients with ovarian cancer, median time to progression was two months and median overall survival was 15 months.

Following treatment, mild injection-site reactions were the most common side effect.

According to Gulley, interest in cancer vaccines is increasing and more study is needed to determine which vaccines will benefit which patients. "The sustained benefit seen in some patients in this study underscores the potential for therapeutic vaccines to impact clinical outcomes without toxicity," he said. "However, more studies in the appropriate patient populations are required to adequately assess efficacy."

The study was funded by the National Cancer Institute.


Contact: Jeremy Moore
American Association for Cancer Research

Page: 1

Related medicine news :

1. Vitamin D, Interferon Alpha Vaccine Show Promise Against Lupus
2. NIH scientists outline steps toward Epstein-Barr virus vaccine
3. Multiple malaria vaccine offers protection to people most at risk
4. HPV Vaccine Might Help Prevent Anal Cancers: Study
5. Researchers develop method to better estimate vaccine coverage
6. Flu Vaccine Isnt Foolproof
7. U.S. Health Officials Back HPV Vaccine for Boys
8. IADR/AADR publish study on dental caries vaccine
9. Study: Obesity limits effectiveness of flu vaccines
10. Experimental Vaccine Shows Promise for Lung Cancer: Study
11. Next-generation allergy vaccines to be developed in Finland to create effective and safe desensitization therapies
Post Your Comments:
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from reveals that behind the tendency to ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
Breaking Medicine Technology: