Navigation Links
Vaccine first to show improved survival rates for metastatic melanoma
Date:6/3/2011

(CHICAGO) For patients with advanced melanoma, which is the most lethal type of skin cancer, the results of a large clinical trial show that a vaccine combined with the immune-boosting drug Interleukin-2 can improve response rate and progression-free survival.

The findings of the study were published in the June 2 issue of New England Journal of Medicine. This marks the first vaccine study in the disease and one of the first in all cancers to show clinical benefit in a randomized Phase III clinical trial.

"This is the first time that a vaccine has shown benefit in the treatment of patients with metastatic melanoma. The trial is an early example of success with a cancer vaccine," said Dr. Howard Kaufman, director for the Rush University Cancer Center and study co-investigator.

"If we can use the body's own defense system to attack tumor cells, we provide a mechanism for ridding the body of cancer without destroying healthy tissue," said Kaufman, who is also an associate dean of Rush Medical College and a professor in the departments of general surgery, internal medicine and immunology and microbiology at Rush University.

Therapeutic cancer vaccines, unlike typical vaccines that prevent infections, are meant to jump-start the immune system to help it battle existing tumors.

Rush was one of 21 centers in the U.S. participating in the trial. Researchers randomly assigned 185 patients with metastatic melanoma to either a combination of the peptide vaccine, which is a small portion of protein that is present on the surface of the melanoma cancer cells, and Interleukin-2, a drug that activates the immune system, or a high dose of Interleukin-2 alone.

The peptide vaccine, known as gp100:209-217 (200M), works by stimulating the patient's T-cells, which is known for controlling immune responses. The injection primes the immune system to recognize the protein and activates the body's cytotoxic T-cells to
'/>"/>

Contact: Deb Song
deb_song@rush.edu
312-942-0588
Rush University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study finds vaccine extends recurrent GBM survival rates by 2 to 3 times
2. ASCO: Experimental vaccine made from frozen immune cells shows promise for prostate cancer patients
3. Therapeutic melanoma vaccine improves response rate, progression-free survival
4. Melanoma Vaccine Shows Promise in Trial
5. Vaccine increases disease-free survival for follicular lymphoma patients
6. Black Americans With Lupus Have Better Response to Flu Vaccine
7. African-Americans with SLE more responsive to flu vaccine than patients of European descent
8. Toward a vaccine for methamphetamine abuse
9. Model developed to improve combination vaccine accessibility worldwide
10. Rino Rappuoli honored for his work in vaccines and vaccinology
11. Insight into HIV immunity may lead to vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... York (PRWEB) January 22, 2015 The federal ... in the U.S. District Court, Southern District of West Virginia ... Inc. in that proceeding’s first bellwether trial. In an Order ... a new trial after finding that C.R. Bard had not ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 For over 20 years, ... Oceanside and Vista area has treated just about every ... personal injury circumstances. And for those same twenty-plus years, the ... of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... Recently, Weddingshe.com has added many trendy Champagne wedding ... revenues in the past three years. Today, the business announces ... According to the sales manager of the company, this is ... 2015. This point can be reflected on the discounted wedding ...
(Date:1/22/2015)... New York, NY (PRWEB) January 22, 2015 ... component of overall health care gains momentum worldwide, Rev. ... York-based HealthCare Chaplaincy Network (HCCN), will be the ... advance spiritual care in Israel’s public health system. , The ...
(Date:1/22/2015)... January 22, 2015 State Forestry Institute ... management system with support from GEOSYSTEMS, a dedicated Hexagon ... solution will leverage Hexagon Geospatial’s ERDAS APOLLO ... as well as point clouds and documents. This effort ...
Breaking Medicine News(10 mins):Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3
... chain of coffee cafes, on opening its 300th outlet in Mumbai ... of 500 by the year 2007. // ,"It ... have played a large role in firmly establishing the coffee café ... Bean Coffee Trading Company Ltd., the parent company of the chain. ...
... survey that found that almost 80 percent of Shanghai women ... ,Yu Junde, coordinator of Survey and head official of Shanghai ... wearing of bras which could affect their health. ... 18 to 50, which revealed that many were wearing very ...
... been documented in Acute Coronary Syndrome patients, instituted aggressive ... Society for Cardiovascular Angiography and Interventions (SCAI) // 29th ... ,By combining data from nine randomized clinical trials and ... analysis was able to put a sharper focus on ...
... have now identified a signaling pathway in the brain, ... food intake. Furthermore, this pathway linked to the development ... weight loss methods in obese individuals. ,Scientists ... pathway mTOR--activated by nutrient and hormonal signals--plays a role ...
... to the belief that adolescent boys tend to take romance ... it comes to heart matters, they might not be so ... is seen outside, an adolescent boy fails to communicate his ... mind. ,Boys are more vulnerable and emotionally engaged ...
... at the Gladstone Institute of Neurological Disease have now ... protein, apolipoprotein E, is indeed produced by neurons.// The ... established a definitive association between the two. ... common forms, one of which, apoE4, is the major ...
Cached Medicine News:Health News:Shanghai Women Don their Bras Improperly 2Health News:Statin Therapy in Patients with Acute Coronary Syndrome Improves Survival 2Health News:Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss 2Health News:Teenage Boys More Vulnerable And Emotionally Engaged In Romantic Relationships 2Health News:Teenage Boys More Vulnerable And Emotionally Engaged In Romantic Relationships 3Health News:Alzheimer's-linked apolipoprotein E produced by neurons, Gladstone study 2
(Date:1/23/2015)... ANGELES , Jan. 23, 2015 A lot of ... best methods for treating  certain illnesses, injuries, or conditions. As ... replace previous treatment methods with ones that they consider to ... hernias, there is not one textbook method of treatment that ...
(Date:1/23/2015)... Jan. 23, 2015  The Partnership to Fight Chronic Disease (PFCD) released ... care leaders and a new study analyzing the impact of increased ... a nationwide coalition working to educate policy makers and the public ... Capitol was focused on how the Iowa ...
(Date:1/23/2015)... 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO )("NW Bio"), ... operable and inoperable solid tumor cancers, announced today that CEO ... Annual Phacilitate Immunotherapy Forum in Washington D.C. ... take place on January 26 at 10:30 a.m. EST at ...
Breaking Medicine Technology:No One-Size-Fits-All Remedy for Hernia Correction 2New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3
... Jan. 10, 2011 Watson Pharmaceuticals, Inc. (NYSE: ... Investor Day on January 21, 2011 in New York City. ... Time and will be simultaneously webcast. At ... for 2011. The presenters will include: Paul Bisaro, Watson,s President ...
... Inc., a privately held, medical device company, today announced ... Annual Healthcare Conference to be held January 10 -13, ... Francisco, CA. (Logo: http://photos.prnewswire.com/prnh/20090409/SF96872LOGO ) ... Wyles, President and CEO, will provide a corporate overview, ...
Cached Medicine Technology:
Intera 3.0T is the most compact high-field clinical whole-body MR system in the world, bringing 3.0T capabilities "out of the tunnel" and into the light of an open, patient-friendly design....
... are designed to provide distraction of ... disc removal, endplate preparation, and insertion ... of several Vertebral Spreaders, Intradiscal Wedges, ... Vertebral Body Positioner. Used in ALIF ...
... is a point-of-care system designed for the ... to as Platelet Rich Plasma - PRP) ... small sample of blood. The Symphony II ... which are found in the platelets. The ...
... gel has an extensive base of experience ... platelet gel. When concentrated autologous platelets are ... structural and functional changes involved in coagulation ... a number of factors including serotonin, fibronectin, ...
Medicine Products: