Navigation Links
Vaccine With Drug Payload Shows Promise Against Tumors
Date:2/11/2013

By Randy Dotinga
HealthDay Reporter

MONDAY, Feb. 11 (HealthDay News) -- Preliminary research produced promising results for a cancer-fighting drug that piggybacks on a virus similar to the one used in the smallpox vaccine.

Patients with advanced liver cancer who were given higher doses of the drug lived months longer than those who took lower doses, and the researchers said some of them are still alive three years later.

There are many caveats. The drug, known as JX-594, is in the early stages of development, and the evidence is years from being ready to be submitted for approval by U.S. Food and Drug Administration officials. The study is also very small, doesn't compare patients who took the drug to those who didn't, and offers no details about its potential cost.

However, the finding is unusual because it suggests that a drug that enters the body through a virus can improve survival in cancer patients, said study co-author Dr. David Kirn, chief medical officer with Jennerex Biotherapeutics, in San Francisco, which is developing the medication. The average survival "more than doubled" in those who took the larger doses. "It's exciting and important for the field, but there's no question we need to confirm it," he said.

William Phelps, director of preclinical and translational cancer research for the American Cancer Society, called the research "promising" and said it reflects the evolution of cancer research toward developing new ways to treat the disease other than the traditional methods of surgery, chemotherapy and radiation, which aim to remove or kill the cancer.

The new drug, like others that are now in development, tries to stimulate the patient's own immune system to fight the cancer. It works by entering the body through an "engineered vaccine" that's similar to the vaccine that prevents smallpox. (The vaccine in this case, like the smallpox vaccine, doesn't cause disease.)

Instead of multiplying in regular cells, the virus in this case only multiplies in cancer cells, study co-author Kirn explained. "It makes thousands of copies and bursts the cancer cell," he said, and then releases a kind of alert to the immune system that tells it that other cancer cells need to be destroyed.

In the new study, the second of three phases required in medical research, scientists gave doses of medication to 30 patients with severe liver cancer. They received three doses, injected into the blood or into their tumors, over a month.

Those who took a higher dose lived for 14 months on average, compared to seven months for those who took the lower dose. The researchers reported that the drug appeared to have an effect not only on the liver tumors but also in cancer cells that had spread elsewhere in the body.

While the study is "by no means definitive" overall, that's good news, said Dr. Neal Meropol, chair of the division of hematology and oncology at Case Western University and the Seidman Cancer Center at University Hospitals, in Cleveland.

As for side effects, patients all felt like they had the flu for about a day, Kirn said. About one-third of those who took the higher dose developed anorexia.

Kirn said the research will continue. He declined to provide a specific estimate of how much the drug will cost, but he did say that its production is not "exceedingly expensive."

The study appears online in the Feb. 10 issue of the journal Nature Medicine.

More information

For more about cancer, visit the U.S. National Library of Medicine.

SOURCES: David Kirn, M.D., president, research and development, and founder and chief medical officer, Jennerex Biotherapeutics, San Francisco; Neal Meropol, M.D., chair, division of hematology and oncology, Seidman Cancer Center, University Hospitals, and Case Western University, Cleveland; William Phelps, Ph.D., director, preclinical and translational cancer research, American Cancer Society, Atlanta; Feb. 10, 2013, Nature Medicine, online


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Young girls more likely to report side effects after HPV vaccine
3. Preteens More Likely to Report HPV Vaccine Side Effects
4. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
5. Early Study Finds Some Promise for Lung Cancer Vaccine
6. From a Failed Vaccine, New Insights Into Fighting HIV
7. From herd immunity and complacency to group panic: How vaccine scares unfold
8. Brain Tumor Vaccine Shows Promise in Early Trial
9. Army researcher develops potential vaccine carrier
10. A physicians guide for anti-vaccine parents
11. Shingles Vaccine Safe, Underutilized, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vaccine With Drug Payload Shows Promise Against Tumors 
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... ... was in a crisis. Her son James, eight, was out of control. Prone to extreme ... “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was ... other children and say he was going to kill them. If we were driving ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... to their offering. The ... commercial environment for MedImmune to enter. The US ageing population ... to drive considerable growth for effective anti-influenza medications. The introduction ... considerably, but development is still in its infancy. ...
(Date:6/23/2016)... Revolutionary technology includes multi-speaker listening to conquer ... in advanced audiology and hearing aid technology, has today ... world,s first internet connected hearing aid that opens up ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... , TwinLink™ - the first dual communication ...
Breaking Medicine Technology: