Navigation Links
Vaccine With Drug Payload Shows Promise Against Tumors
Date:2/11/2013

By Randy Dotinga
HealthDay Reporter

MONDAY, Feb. 11 (HealthDay News) -- Preliminary research produced promising results for a cancer-fighting drug that piggybacks on a virus similar to the one used in the smallpox vaccine.

Patients with advanced liver cancer who were given higher doses of the drug lived months longer than those who took lower doses, and the researchers said some of them are still alive three years later.

There are many caveats. The drug, known as JX-594, is in the early stages of development, and the evidence is years from being ready to be submitted for approval by U.S. Food and Drug Administration officials. The study is also very small, doesn't compare patients who took the drug to those who didn't, and offers no details about its potential cost.

However, the finding is unusual because it suggests that a drug that enters the body through a virus can improve survival in cancer patients, said study co-author Dr. David Kirn, chief medical officer with Jennerex Biotherapeutics, in San Francisco, which is developing the medication. The average survival "more than doubled" in those who took the larger doses. "It's exciting and important for the field, but there's no question we need to confirm it," he said.

William Phelps, director of preclinical and translational cancer research for the American Cancer Society, called the research "promising" and said it reflects the evolution of cancer research toward developing new ways to treat the disease other than the traditional methods of surgery, chemotherapy and radiation, which aim to remove or kill the cancer.

The new drug, like others that are now in development, tries to stimulate the patient's own immune system to fight the cancer. It works by entering the body through an "engineered vaccine" that's similar to the vaccine that prevents smallpox. (The vaccine in this case, like the smallpox vaccine, doesn't cause disease.)

Instead of multiplying in regular cells, the virus in this case only multiplies in cancer cells, study co-author Kirn explained. "It makes thousands of copies and bursts the cancer cell," he said, and then releases a kind of alert to the immune system that tells it that other cancer cells need to be destroyed.

In the new study, the second of three phases required in medical research, scientists gave doses of medication to 30 patients with severe liver cancer. They received three doses, injected into the blood or into their tumors, over a month.

Those who took a higher dose lived for 14 months on average, compared to seven months for those who took the lower dose. The researchers reported that the drug appeared to have an effect not only on the liver tumors but also in cancer cells that had spread elsewhere in the body.

While the study is "by no means definitive" overall, that's good news, said Dr. Neal Meropol, chair of the division of hematology and oncology at Case Western University and the Seidman Cancer Center at University Hospitals, in Cleveland.

As for side effects, patients all felt like they had the flu for about a day, Kirn said. About one-third of those who took the higher dose developed anorexia.

Kirn said the research will continue. He declined to provide a specific estimate of how much the drug will cost, but he did say that its production is not "exceedingly expensive."

The study appears online in the Feb. 10 issue of the journal Nature Medicine.

More information

For more about cancer, visit the U.S. National Library of Medicine.

SOURCES: David Kirn, M.D., president, research and development, and founder and chief medical officer, Jennerex Biotherapeutics, San Francisco; Neal Meropol, M.D., chair, division of hematology and oncology, Seidman Cancer Center, University Hospitals, and Case Western University, Cleveland; William Phelps, Ph.D., director, preclinical and translational cancer research, American Cancer Society, Atlanta; Feb. 10, 2013, Nature Medicine, online


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Young girls more likely to report side effects after HPV vaccine
3. Preteens More Likely to Report HPV Vaccine Side Effects
4. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
5. Early Study Finds Some Promise for Lung Cancer Vaccine
6. From a Failed Vaccine, New Insights Into Fighting HIV
7. From herd immunity and complacency to group panic: How vaccine scares unfold
8. Brain Tumor Vaccine Shows Promise in Early Trial
9. Army researcher develops potential vaccine carrier
10. A physicians guide for anti-vaccine parents
11. Shingles Vaccine Safe, Underutilized, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Vaccine With Drug Payload Shows Promise Against Tumors 
(Date:12/5/2016)... ... 06, 2016 , ... For many years, Andrew G. Zubinas has ... The beauty of the Lithuanian language and its poetry inspired him in ... Zubinas lyrically explores all aspects of a living, breathing forest where nothing ever stays ...
(Date:12/5/2016)... ... December 05, 2016 , ... “Epilepsy ... through tomorrow, December 6th, sparks a conversation about epilepsy, bearing down on the ... 26 people will be diagnosed with epilepsy within their lifetime. With such a ...
(Date:12/5/2016)... Reading, PA (PRWEB) , ... December 05, 2016 , ... ... partner in the United States and Canada for distribution of their natural fruits ... Hansen colors line is an exciting addition to our Life Sciences product portfolio,” ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... Partners ("GPP") portfolio company, today announced it has acquired the assets of ... was previously a subsidiary of Chiltern International and focuses on clinical trial ...
(Date:12/5/2016)... (PRWEB) , ... December 05, 2016 , ... The new ... the individual looking to buy neoprene knee sleeves for lifting and any ... design focuses heavily on two main aspects to provide a higher quality knee sleeve ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... Eisai Inc. announced today new analyses and ... of the American Epilepsy Society (AES). ... adjunctive therapy for the treatment of partial onset seizures ... generalized tonic-clonic seizures (PGTC) in patients with epilepsy who ... Important Safety Information for FYCOMPA, including Boxed WARNING for ...
(Date:12/5/2016)... , Dec 5, 2016 Research and ... and Pregnancy Rapid Test Market Size, Share, Development, Growth and Demand ... ... The global female fertility and pregnancy rapid test market is ... global Female fertility and pregnancy rapid test market is witnessing high ...
(Date:12/5/2016)... AVIV, Israel , December 5, 2016 ... to identifying, in-licensing and developing promising therapeutic candidates, presents positive ... for BL-8040, the Company,s leading oncology platform at the ongoing ... in San Diego, California . ... , , ...
Breaking Medicine Technology: