Navigation Links
Vaccine Stops Tumor Spread in Mice

Treatment may be used one day as part of cancer-fighting arsenal, but more study is needed

SUNDAY, April 18 (HealthDay News) -- A new study in mice suggests that a transcription factor normally found in male germ cells could become a target for cancer vaccines.

A transcription factor is a protein that controls the transfer (or transcription) of genetic material from the DNA to messenger RNA. This particular factor, known as Brother of the Regulator of Imprinted Sites (BORIS), promotes tumor growth.

Scientists were able to develop a vaccine from BORIS that was effective in helping stop the spread of a breast cancer-like tumor to other parts of the body, a process known as metastasis.

The vaccine "is capable of inducing strong and effective antitumor immunity, but the efficacy of this [strategy] could be even better if one could eliminate immune suppressor cells," lead researcher Michael G. Agadjanyan, head of the department of immunology and professor at the University of California, Irvine's Institute for Molecular Medicine, said in a press release.

Researchers tested the value of a mutated virus using the factor on mice with a form of cancer similar to breast cancer found in humans. They delivered the vaccine into the body by using immune cells known as dendritic cells, whose treelike branches form connections with other cells in the body.

The factor delivered by dendritic cells "elicited strong antitumor cellular immune responses in tumor-free mice," Agadjanyan said. "More importantly, therapeutic vaccination dramatically inhibited both tumor growth and the number of metastases in the lungs of tumor-bearing mice."

He cautioned, however, that the BORIS-based vaccine did not entirely eliminate tumors or stop the spread of cancer. For that reason, it should be combined with other strategies that enlist the immune system to combat cancer, he said.

The study findings were scheduled to be released Sunday at the annual meeting of the American Association for Cancer Research in Washington D.C.

More information

The U.S. National Cancer Institute has an A-to-Z list of cancer types.

-- Randy Dotinga

SOURCE: American Association for Cancer Research, press release, April 18, 2010.

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Guillain-Barre Syndrome Very Rare After H1N1 Vaccine
2. Flu Vaccine With Both B Strains May Offer Better Protection
3. Vaccine Reverses Type 1 Diabetes in Mice
4. Clinical trial to test whether vaccine can effectively treat melanoma
5. Building a better flu vaccine: Add second strain of influenza B
6. Oral Vaccine May Help People With COPD
7. Genetic Engineering Raises Hope for Lyme Disease Vaccine
8. Only 1 in 4 Americans Got H1N1 Vaccine
9. Clues Found to How Different Flu Vaccines Work
10. GSK Joins Global Vaccine Alliance to Help Prevent Millions of Children from Contracting Pneumococcal Disease in the Worlds Poorest Countries
11. Miles for Hope’s Moving Towards A Cure(SM) Brain Tumor Walk in Boston Raising Funds for Brain Tumor Vaccine and Massachusetts General Hospital
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... ... management services, today announced its partnership with WPC Healthcare , a provider ... systems and organizes the data into an aggregated data repository necessary to perform ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... announced today their sponsorship of the Microsoft Dynamics AXUG, GPUG and NAVUG Summits ... GPUG Summit and NAVUG Summit are independent user conferences designed and led by ...
(Date:10/13/2015)... ... 13, 2015 , ... Relay (, a technology company that ... significant contract that will provide its award-winning private messaging solution to Independence Blue ... success of its Relay program, IBX Wire™, which now has over 550,000 members ...
(Date:10/13/2015)... ... ... A child without a healthy mouth is much more likely to have ... system, has joined with Global Dental Relief (GDR) to help bring dental ... purchased, SmileCareClub will donate one clinic visit to a child in Kenya. , “When ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... targets the unique health needs of new moms. Postnatal Omega-3, which has ... ), utilizes Nordic Naturals’ exclusive, new, ultra-concentrated omega-3 oil. This breakthrough ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... Oct. 13, 2015  SeraCare Life Sciences, a leading ... that the company,s precision medicine business unit has launched ... materials for next-generation sequencing (NGS)-based tumor profiling assays.  The ... the same mixture of mutations in key oncogenes and ... AF20 mix , but is offered at five additional ...
(Date:10/13/2015)... 2015  Graduate students across the country, with ... will soon have the opportunity to learn about ... drug discovery and development process. Eli Lilly and ... 10 leaders from academic institutions to create an ... of Drug Development."  Lilly will formally unveil the ...
(Date:10/13/2015)... WASHINGTON , Oct. 13, 2015 /PRNewswire/ ... the first-ever direct-to-consumer laboratory home testing kit ... and digital technologies provide an unparalleled, detailed ... of breast milk—fats, proteins, carbs and key ... digital portal for personal health tracking.  In addition, ...
Breaking Medicine Technology: