Navigation Links
Vaccine Stops Tumor Spread in Mice

Treatment may be used one day as part of cancer-fighting arsenal, but more study is needed

SUNDAY, April 18 (HealthDay News) -- A new study in mice suggests that a transcription factor normally found in male germ cells could become a target for cancer vaccines.

A transcription factor is a protein that controls the transfer (or transcription) of genetic material from the DNA to messenger RNA. This particular factor, known as Brother of the Regulator of Imprinted Sites (BORIS), promotes tumor growth.

Scientists were able to develop a vaccine from BORIS that was effective in helping stop the spread of a breast cancer-like tumor to other parts of the body, a process known as metastasis.

The vaccine "is capable of inducing strong and effective antitumor immunity, but the efficacy of this [strategy] could be even better if one could eliminate immune suppressor cells," lead researcher Michael G. Agadjanyan, head of the department of immunology and professor at the University of California, Irvine's Institute for Molecular Medicine, said in a press release.

Researchers tested the value of a mutated virus using the factor on mice with a form of cancer similar to breast cancer found in humans. They delivered the vaccine into the body by using immune cells known as dendritic cells, whose treelike branches form connections with other cells in the body.

The factor delivered by dendritic cells "elicited strong antitumor cellular immune responses in tumor-free mice," Agadjanyan said. "More importantly, therapeutic vaccination dramatically inhibited both tumor growth and the number of metastases in the lungs of tumor-bearing mice."

He cautioned, however, that the BORIS-based vaccine did not entirely eliminate tumors or stop the spread of cancer. For that reason, it should be combined with other strategies that enlist the immune system to combat cancer, he said.

The study findings were scheduled to be released Sunday at the annual meeting of the American Association for Cancer Research in Washington D.C.

More information

The U.S. National Cancer Institute has an A-to-Z list of cancer types.

-- Randy Dotinga

SOURCE: American Association for Cancer Research, press release, April 18, 2010.

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Guillain-Barre Syndrome Very Rare After H1N1 Vaccine
2. Flu Vaccine With Both B Strains May Offer Better Protection
3. Vaccine Reverses Type 1 Diabetes in Mice
4. Clinical trial to test whether vaccine can effectively treat melanoma
5. Building a better flu vaccine: Add second strain of influenza B
6. Oral Vaccine May Help People With COPD
7. Genetic Engineering Raises Hope for Lyme Disease Vaccine
8. Only 1 in 4 Americans Got H1N1 Vaccine
9. Clues Found to How Different Flu Vaccines Work
10. GSK Joins Global Vaccine Alliance to Help Prevent Millions of Children from Contracting Pneumococcal Disease in the Worlds Poorest Countries
11. Miles for Hope’s Moving Towards A Cure(SM) Brain Tumor Walk in Boston Raising Funds for Brain Tumor Vaccine and Massachusetts General Hospital
Post Your Comments:
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... , ... First Choice Emergency Room , the largest network of independent ... Director of its new Mesquite-Samuell Farm facility. , “We are pleased to announce ... Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... Those ... deal with these feelings, many turn to unhealthy avenues, such as drug or alcohol ... of Marne, Michigan, has released tools for healthy coping following a traumatic event. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
(Date:6/23/2016)... -- The Biotechnology industry might still be ... opportunities to investors. assesses the recent performances of ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ), and Regeneron Pharmaceuticals Inc. (NASDAQ: REGN ... complimentary trade alerts at: ...
(Date:6/23/2016)... Leading BioSciences Inc., a clinical-stage biopharmaceutical ... from a breakdown of the mucosal barrier, today ... as chief executive officer. Mr. Doyle, a ... and board of directors, previously served as chief ... provide continued leadership and strategic direction to the ...
Breaking Medicine Technology: