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Vaccine Shows Promise Against Mosquito-Borne Virus
Date:8/15/2014

. After a second shot, all the participants developed high amounts of antibodies. These antibodies were long-lasting and were detected six months after the last vaccination, Ledgerwood said.

The vaccine was also well-tolerated with no serious side effects, she said. Four volunteers reported mild to moderate side effects, including an increase in an enzyme in liver and heart cells that rises when these organs are damaged, and a low white blood cell count that leaves people vulnerable to infections, the researchers noted.

After 11 months, the levels of antibodies were similar to those found in people who had been infected with chikungunya, which suggests that the vaccine might protect people over the long haul, Ledgerwood said.

In addition, the vaccine made antibodies against multiple types of the virus, so it might be effective against any strain of chikungunya, she noted.

More information

Visit the U.S. Centers for Disease Control and Prevention for more on chikungunya.

SOURCES: Julie Ledgerwood, D.O., chief, clinical trials program, U.S. National Institute of Allergy and Infectious Diseases; Ann Powers, Ph.D., research microbiologist, U.S. Centers for Disease Control and Prevention; Aug. 15, 2014, The Lancet, online


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