Navigation Links
Vaccinating boys against human papillomavirus not cost-effective
Date:10/8/2009

Boston, MA -- Persistent infection with high-risk types of human papillomavirus (HPV), a sexually transmitted virus, is known to be a cause of cervical cancer. Current guidelines prioritize HPV vaccination of pre-adolescent girls, which has been shown to be cost-effective in previous studies, but the value of vaccinating boys in the United States has been unclear. In a new study, Harvard School of Public Health (HSPH) researchers found that if vaccine coverage and efficacy are high in girls, a universal recommendation to vaccinate young boys is unlikely to provide comparatively good value for resources, compared with vaccinating girls only.

The study appears online October 9, 2009, in The British Medical Journal and will appear in a later print edition.

The HPV vaccine for boys is already licensed in a number of countries and is currently being considered by the U.S Food and Drug Administration (FDA).

"With the near-term possibility of the HPV vaccine being available to boys in the U.S., policymakers will need to decide whether or not to recommend vaccinating boys," said Jane Kim, assistant professor of health decision science and lead author of the study. "To inform these deliberations, both the incremental health benefits that would accrue with vaccination of boys and girls and the economic costs of the program should be compared to those associated with vaccination of girls alone."

Motivated to inform current decision making, Kim and co-author Sue Goldie, professor of health decision science, evaluated the most current epidemiological, clinical and economic data on HPV infections and cervical disease. Because the most important health benefits (e.g., prevention of cervical cancer) from adolescent HPV vaccination will not be observed for years, and possibly decades, they used computer-based disease models to simulate the course of HPV-related diseases in the U.S. population over time. The analysis looked at the vaccine's potential benefits on a comprehensive set of HPV-related conditions among females and males, including cervical and non-cervical HPV-related cancers, genital warts and juvenile onset recurrent respiratory papillomatosis, a rare but severe respiratory condition usually diagnosed in infancy that may be related to a mother's infection with genital warts.

The results showed that, assuming 75% vaccination coverage and lifelong vaccine protection against cervical disease, routine HPV vaccination of 12-year-old girls was associated with a cost-effectiveness ratio of $40,310 per quality-adjusted life year (QALY), a health metric used to reflect both the excess mortality and reduced quality of life associated with disease. In the U.S., interventions with cost-effectiveness ratios below $50,000 or $100,000 per QALY are informally considered good value for the money. Including boys in the vaccination program had a cost-effectiveness ratio of $290,290 per QALY when compared to vaccinating girls only, exceeding the threshold for good value.

The results were robust across a range of alternative scenarios, such as changes in screening practice, decreased vaccine efficacy in boys, shorter duration of vaccine protection, and the inclusion of other HPV-related outcomes noted above. The authors acknowledge, however, that there are many uncertain factors that can influence the findings. For example, if efficacy against long-term HPV-related diseases in both girls and boys remains high, coverage in girls is low, or the vaccine price is substantially lowered, vaccinating boys looks more attractive.

Since the FDA may consider vaccinating boys in the near future, the findings provide important insight about guidelines regarding what groups to include in routine HPV vaccination recommendations. The authors emphasize, "this analysis does not address decision-making at the individual level; indeed, families who are considering HPV vaccination for an individual boy may consider the vaccine benefits worthwhile in terms of reducing the future risk of genital warts and possibly other health conditions."

While the authors conclude that routine vaccination of boys is unlikely to provide comparative value to other public health interventions vying for resources, they emphasize that the study was conducted from a public health perspective and with the objective of informing general policy recommendations at the population-level. "Based on currently available information, efforts for cervical cancer prevention in the U.S. should focus on HPV vaccination of pre-adolescent girls and continued cervical cancer screening in adulthood," said Kim.


'/>"/>

Contact: Todd Datz
tdatz@hsph.harvard.edu
617-432-3952
Harvard School of Public Health
Source:Eurekalert

Related medicine news :

1. Vaccinating children may be effective at helping control spread of influenza, experts say
2. Eleven Health & Consumer Groups Urge Federal Court to Reject Tobacco Companies Lawsuit Against FDA Tobacco Regulation Law
3. Insurance Industry Successful in Initial Fight Against Public Option; Public Feels Left Out
4. Anchor Bay Entertainment Joins Forces With Susan G. Komen for the Cure(R) in the Fight Against Breast Cancer
5. UCF Athletes Set Example While Getting Protected Against Flu
6. Racing against the clock to distribute H1N1 flu vaccine
7. Ann Taylor Supports The Fight Against Breast Cancer
8. Association of Retired Xerox Employees Initiate Legal Proceedings Against Xerox Corporation
9. New vaccine delivery may be more effective against measles
10. Gut worms may protect against house-dust mite allergy
11. Texas Doctor Files Case Pro Se in U.S. Supreme Court Against Insurance Giant on Integrity and Unethical Practices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... Houston, TX (PRWEB) , ... February 27, 2017 ... ... the 75,000 customer threshold mark last week. In addition, Discount Power's RCE (Residential ... Volterra Energy LLC in March 2014. The company had 800 customers and 2,250 ...
(Date:2/26/2017)... ... February 25, 2017 , ... The February 13, 2017, assassination of Kim Jong-nam, ... nerve agents and the deadly use of chemical weapons. Many questions exist about the ... small doses can be lethal. , Jay Jagannathan, M.D., of Michigan-based Jagannathan Neurosurgical Institute, ...
(Date:2/26/2017)... ... 2017 , ... IndustryArchive.Org . is announcing a new way for B2B ... now only pay for B.A.N.T. quality sales leads based on the Sellers decision to ... new reality that B2B buyers are controlling the sales process via the Internet and ...
(Date:2/25/2017)... ... ... FCPX users now have the ability to sharpen a desired color range ... have total control over sharpening amount, sharpening radius, threshold, horizontal sharpening, vertical sharpening, and ... can visually see the color range effected with ease all within Final Cut ...
(Date:2/24/2017)... ... February 24, 2017 , ... An in-depth computational analysis ... University of Pittsburgh points to eight genes that may explain why susceptibility to one ... the results of a study published today in the journal npj Schizophrenia. , ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... N.J. , Feb. 27, 2017  Interpace Diagnostics ... that provides clinically useful molecular diagnostic tests and pathology ... be presented at the upcoming United States ... being held March 4-10, 2017 in San ... reflect a review of data from the Company,s extensive ...
(Date:2/27/2017)... , Feb. 27, 2017  International Biophysics Corporation, a ... , today announced a 34% revenue growth in 2016 ... increase in unit sales.  This growth was fueled by its ... in addition to the expansion of its global sales of ... International Biophysics, CEO, "As we enter our 25 th ...
(Date:2/27/2017)... Calif. , Feb. 27, 2017   Vitasome ... line of nutritional supplements using its groundbreaking new liposome ... 90 percent of potency through digestion per Physician,s ... supplements solve the problem of nutritional waste and are ... degradation during digestive processes Improve bioavailability ...
Breaking Medicine Technology: