Navigation Links
VIB and UZ-KU Leuven join forces and bring state-of-the-art technology to Flanders
Date:11/6/2007

Belgium - Flemish biotechnologists have a world-wide reputation for deciphering genetic code. In order to further strengthen this leading position, two Flemish research institutes are joining forces and bringing new technology to Flanders which will record DNA 100 times faster than current methods. This is an essential asset as these DNA analyses hold the key to the decipherment and treatment of genetic disorders.

Why decipher DNA?

The full DNA of an organism - the genome - determines what that organism looks like and how it functions. The better we understand this, the more we can learn about the intricacies of living beings. We know the broad outline of human DNA, and scientists are now determining the DNA differences between people. These differences characterise the diversity of people but they also hold the key to a higher risk for genetic disorders such as dementia, psychosis, diseases of the heart and blood vessels, and cancer. If we know and understand the differences, we can also use them as the foundation for new treatments.

However, to record these differences efficiently, it is essential that everything moves much faster than the current technology allows. This has now become possible. So-called new generation sequence technology has recently been developed, but it is still very expensive.

Nevertheless, VIB and UZ.-K.U. Leuven have joined forces to give Flemish scientists access to this state-of-the-art technology. Via a co-ordinated investment program, they are bringing Roches DNA sequence technology platform, the so-called 454 sequencing, to Flanders.

What is 454 sequencing?

This technique provides an ingenious manner to super-efficiently decipher DNA code. DNA fragments are isolated in drops of water, which function as micro-reactors. Using these pieces of DNA, 10 million identical copies are made and they are simultaneously (but individually) sequenced. This is all done on a tablet the size of a credit card which contains 1.6 million little holes in which sequence reactions are generated. Seven hours later, the DNA sequences are produced by the computer, thereby rendering a wealth of data. This technology has the advantage of producing large parts of sequences from the genomes that are to be recorded, which benefits not only the speed but also the accuracy of the information. In short, the larger the pieces of the puzzle, the quicker and more precise the image of the entire picture.

Determining sequences can now be done 100 times faster than the technologies which are currently being used. With the next version of the new technology, which should be available within a year, one experiment will yield yet another 10 times more sequence, so 1000 times more than now. Therefore, with the new technology, Flemish scientists will in one day be able to gather DNA data that would today take 3 years to compile. This is truly revolutionary!

Applications for VIB and UZ-K.U. Leuven

In order to make optimal use of these substantial investments, VIB and UZ-K.U.Leuven are mutually coordinating activities on both units. Both parties will exchange expertise and will make capacity available to one another. In addition, VIB and UZ-K.U.Leuven will be able to grant Flemish researchers from other centers access to this revolutionary technology via this platform.

The 454 sequencer will be embedded in the Genetic Service Facility of the VIB Department of Molecular Genetics, University of Antwerp under the direction of Christine Van Broeckhoven . New technology will be developed under the supervision of Jurgen Del-Favero, supporting basic research such as sequencing new, full genomes of interesting organisms (e.g. pathogenic organisms) and tracing DNA differences that cause illnesses. On top of that, there will be a large investment in translational research focusing on the development of more efficient and cheaper genetic diagnostic tests. The University of Antwerp guarantees a structural contribution towards the cost of this new investment.

Quote from VIB: This technology will allow us to more quickly identify the molecular mechanisms of illness.

With this investment, UZ-K.U.Leuven wishes to stimulate translational research which will, through interaction between researchers and clinicians, generate genuine innovations in the field of patient care. A powerful DNA diagnostic platform to find mutations in genes which cause, among other things, breast and bowel cancer, or are involved in illnesses such as heart, vascular illnesses and diabetes, can contribute to significant diagnostic and therapeutic possibilities.

Quote from UZ-K.U.Leuven: This technology brings fundamental research closer to patient applications.


'/>"/>

Contact: Ann Van Gysel
info@vib.be
329-244-6611
VIB, Flanders Institute for Biotechnology
Source:Eurekalert

Related medicine news :

1. Can cancer drugs combine forces?
2. MEDEX Global Group & Harvard Medical International Join Forces to Create the Most Comprehensive Health Information Resource for International Travelers
3. The Will and Jada Smith Family Foundation and Maybelline Join Forces With the Lupus Foundation of America for a Star-studded Gala to Raise Awareness for Lupus
4. Health Organizations Join Forces Around Quit-Smoking Help
5. The Cardiovascular Multimedia Network (CVMD) and the International Society of Endovascular Specialists (ISES) Join Forces to Educate Practitioners Worldwide Through Electronic Media
6. Medsphere & Keane Join Forces to Provide Healthcare Enterprises With Integrated Electronic Health Record & Revenue Cycle Management Systems
7. IAEA and NFCR join forces to fight cancer in developing world
8. Naked Juice Brings Consumers Happiness by the Billions With First 100% Juice Smoothie Containing Probiotics
9. Vitamin Relief Brings Needed Nutrition to School District Resurrecting After Katrina
10. Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During America on the Move Week With the YMCA, September 22-29, 2007
11. PSI Brings its Pioneering Efforts to a Close
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... Registered nurses, ... free CEU seminar titled, “Stroke Management: Time to Act, Time to Heal” on Thursday, ... in Whippany, N.J. The presenter is Vishal Chedda, president of ANSA Consultants, who ...
(Date:2/11/2016)... ... February 12, 2016 , ... The Journal of Pain ... 0.416 in 2013. The SJR uses data taken from the Scopus database (Elsevier B.V.) ... number of citations received by the journal over a three year period and also ...
(Date:2/11/2016)... IL (PRWEB) , ... February 11, 2016 , ... ... to the healthcare industry, ranked among the top five firms in the “2015/2016 ... and HIT Implementation Support and Staffing. KLAS is a research and insights firm ...
(Date:2/11/2016)... ... 11, 2016 , ... Thermi™, a world leader in thermistor-regulated ... the promotions of Allison Kelly to executive vice president of the company’s new ... of North American capital sales, and Wendy Oseas to vice president of global ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... an unparalleled clinical decision support technology, with highly adaptable algorithms, has been updated ... a patient has signs and symptoms consistent with Zikas and a travel history ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Potrero Medical, Inc., the developer of the Accuryn™ critical care ... George M. Rapier, III , MD, to its Board of ... is one of the nation,s largest physician owned practice management ... Texas and Florida . ... medicine practice, he has been instrumental to the company,s growth ...
(Date:2/11/2016)... , Feb. 11, 2016  AfterPill.com is reporting that ... alcohol abstinence for all women who are at risk ... U.S. each year and raises the risks of unprotected ... --> According to the Guttmacher Institute, there ... women of child-bearing age, who have sex without the ...
(Date:2/11/2016)... -- Proliant Biologicals is proud to announce the opening of ... The facility is located on the North Island of ... Boone , Iowa.  The equipment design ... in the U.S. facility, with critical processing systems coming ... --> Boone , Iowa.  The ...
Breaking Medicine Technology: