Navigation Links
VIB-K.U. Leuven scientists clear the way to alternative anti-angiogenic cancer therapy

Leuven Scientists attached to VIB and K.U.Leuven have succeeded in decoding a potential new anti-cancer mechanism. The researchers discovered that normalizing abnormal tumor blood vessels through HRG (histidine-rich glycoprotein) prevents metastasis of tumor cells and enhances chemotherapy efficiency. In tumors, vessels formation is disturbed, leading to inefficient delivery of chemotherapeutic drugs and allowing cancer cells to escape to other parts of the body (metastasis). The normalization of tumor blood vessel formation through HRG works by repressing the production of the Placental Growth Factor PlGF. Anti-PlGF therapy is now being tested as a new agent against cancer by ThromboGenics in collaboration with Roche. The recently discovered mechanism offers alternative possibilities for cancer treatment.

Cancer and the formation of blood vessels (angiogenesis)

Every growing tissue is supplied with oxygen and nutrients through our blood vessels. However, tumors grow much faster than normal tissue and have a higher need for nutrients. Consequently, tumor cells start generating growth factors to stimulate the growth of new blood vessels. However, the resulting blood vessels are of abnormal shape, causing poor blood flow and little oxygen supply to the cancer cells. The oxygen shortage encourages cancer metastasis and eventually leads to a malignant cancer. Furthermore, the abnormal shape of the blood vessels hampers the supply and efficiency of anti-cancer drugs.

Conventional anti-angiogenic therapy

Conventional anti-angiogenic cancer therapy in which a growth factor is eliminated may aggravate tumor metastasis, becase. Because of this, there has in recent years been a greater focus on anti-angiogenic therapies which normalize the blood vessels supplying the tumor. This would reduce the oxygen shortage, with the result that the cancer cells will tend to travel less to other parts of the body and anti-cancer drugs can be delivered more efficiently.

Histidine-rich glycoprotein (HRG)

Charlotte Rolny, Max Mazzone and their colleagues from the VIB Vesalius Research Center, K.U.Leuven, have under the direction of Peter Carmeliet and in collaboration with VIB researchers from the Vrije Universiteit Brussel and colleagues from Sweden studied the mechanism behind the known anti-cancer activity of the protein HRG. The results of their experiments show that HRG, a protein distributed in the tumor stroma, displays anti-cancer activity by combating tumor progression and spread and stimulating normalization of tumor blood vessels. The underlying basis of this action is the capacity of HRG to suppress the angiogenic factor PlGF.

Towards an alternative cancer therapy

Revealing the mechanism behind the anti-cancer activity of HRG opens up new horizons for cancer treatment. The larger a tumor becomes, the higher its oxygen requirement. However, the tumor vessels that are formed are abnormal in shape, leading to poor blood and oxygen flow. This oxygen shortage stimulates cancer cell metastasis. Stimulating HRG in the tumor stroma counters tumor progression and spread while at the same time being conducive to normalization of tumor blood vessels which enhances the efficacy of chemotherapy. Moreover, these data also support eliminating PlGF for the treatment of cancer.


Contact: Joris Gansemans
VIB (the Flanders Institute for Biotechnology)

Related medicine news :

1. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 12 top young scientists
2. Scientists Aim for Test That Spots Single Cancer Cell in Blood Sample
3. Scientists Aim for Test That Could Spot Single Cancer Cell in Blood
4. Scientists Spot DNA Linked With Dangerous Heart Rhythms
5. Ion channel responsible for pain identified by UB neuroscientists
6. Scientists decode secrets of a very common virus that can cause cancer
7. Scientists Spot Genetic Areas Key to Embryonic Development
8. UNC scientists discover potential strategy to improve cancer vaccines
9. Scientists Raise Fat-Burning Levels in Mice
10. Scripps Research scientists awarded $2.35 million to study new obesity treatment
11. NIH scientists identify mechanism responsible for spreading biofilm infections
Post Your Comments:
(Date:11/30/2015)... , ... November 30, 2015 , ... ... Beard and Brooke Bennett are collaborating with brands across various categories through traditional ... influential figures make up an elite group of Gold Medal Moms who can ...
(Date:11/30/2015)... Garden City, NY (PRWEB) , ... December 01, 2015 , ... ... as a 2015-2016 inductee into its VIP Woman of the Year Circle. She ... is the nation’s leading networking organization exclusively for professional women, boasting more than 850,000 ...
(Date:11/30/2015)... ... 2015 , ... Being a caregiver for someone you love ... Care System, the Caregiver Support Program promotes the health and wellbeing of family ... percent report that their role as a caregiver has created marital strain,” said ...
(Date:11/30/2015)... ... November 30, 2015 , ... According to research by ... require dental technicians to be certified or obtain continuing education. To increase awareness ... In Your Mouth?” campaign to inform dentists that the technicians they trust could ...
(Date:11/30/2015)... ... November 30, 2015 , ... The Museum of Science & ... a new era of publicly accessible automated technology. Now, by popular demand, the ... guests an up-close look at the shuttle at MOSI’s main entrance. This experience ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... -- IBA Molecular North America, Inc. (IBAMNA), a U.S. leader ... as of January 1, 2016, it will do business ... rebrand the company reflects a refined vision for the ... relationship with Zevacor Molecular.  Both IBAMNA and Zevacor Molecular ... Peter Burke , Vice President Sales and ...
(Date:11/30/2015)... -- North America was valued at ... a CAGR of 7.6% from 2015 to 2020. --> ... in 2014, and is expected to grow at a CAGR of ... new Market Research Report "North America Cardiac Output Monitoring Devices Market ... care, others) - Analysis And Forecast To 2020", the cardiac output ...
(Date:11/30/2015)... 30, 2015  Kevin Smith has been appointed ... global pioneer in wireless monitoring of vital signs.  ... , Mr. Smith will be responsible for ... strategy.  He will also directly oversee partnering with ... evidence for SensiumVitals, the first early warning detection ...
Breaking Medicine Technology: