Navigation Links
VIB-K.U. Leuven scientists clear the way to alternative anti-angiogenic cancer therapy

Leuven Scientists attached to VIB and K.U.Leuven have succeeded in decoding a potential new anti-cancer mechanism. The researchers discovered that normalizing abnormal tumor blood vessels through HRG (histidine-rich glycoprotein) prevents metastasis of tumor cells and enhances chemotherapy efficiency. In tumors, vessels formation is disturbed, leading to inefficient delivery of chemotherapeutic drugs and allowing cancer cells to escape to other parts of the body (metastasis). The normalization of tumor blood vessel formation through HRG works by repressing the production of the Placental Growth Factor PlGF. Anti-PlGF therapy is now being tested as a new agent against cancer by ThromboGenics in collaboration with Roche. The recently discovered mechanism offers alternative possibilities for cancer treatment.

Cancer and the formation of blood vessels (angiogenesis)

Every growing tissue is supplied with oxygen and nutrients through our blood vessels. However, tumors grow much faster than normal tissue and have a higher need for nutrients. Consequently, tumor cells start generating growth factors to stimulate the growth of new blood vessels. However, the resulting blood vessels are of abnormal shape, causing poor blood flow and little oxygen supply to the cancer cells. The oxygen shortage encourages cancer metastasis and eventually leads to a malignant cancer. Furthermore, the abnormal shape of the blood vessels hampers the supply and efficiency of anti-cancer drugs.

Conventional anti-angiogenic therapy

Conventional anti-angiogenic cancer therapy in which a growth factor is eliminated may aggravate tumor metastasis, becase. Because of this, there has in recent years been a greater focus on anti-angiogenic therapies which normalize the blood vessels supplying the tumor. This would reduce the oxygen shortage, with the result that the cancer cells will tend to travel less to other parts of the body and anti-cancer drugs can be delivered more efficiently.

Histidine-rich glycoprotein (HRG)

Charlotte Rolny, Max Mazzone and their colleagues from the VIB Vesalius Research Center, K.U.Leuven, have under the direction of Peter Carmeliet and in collaboration with VIB researchers from the Vrije Universiteit Brussel and colleagues from Sweden studied the mechanism behind the known anti-cancer activity of the protein HRG. The results of their experiments show that HRG, a protein distributed in the tumor stroma, displays anti-cancer activity by combating tumor progression and spread and stimulating normalization of tumor blood vessels. The underlying basis of this action is the capacity of HRG to suppress the angiogenic factor PlGF.

Towards an alternative cancer therapy

Revealing the mechanism behind the anti-cancer activity of HRG opens up new horizons for cancer treatment. The larger a tumor becomes, the higher its oxygen requirement. However, the tumor vessels that are formed are abnormal in shape, leading to poor blood and oxygen flow. This oxygen shortage stimulates cancer cell metastasis. Stimulating HRG in the tumor stroma counters tumor progression and spread while at the same time being conducive to normalization of tumor blood vessels which enhances the efficacy of chemotherapy. Moreover, these data also support eliminating PlGF for the treatment of cancer.


Contact: Joris Gansemans
VIB (the Flanders Institute for Biotechnology)

Related medicine news :

1. Damon Runyon Cancer Research Foundation awards prestigious fellowships to 12 top young scientists
2. Scientists Aim for Test That Spots Single Cancer Cell in Blood Sample
3. Scientists Aim for Test That Could Spot Single Cancer Cell in Blood
4. Scientists Spot DNA Linked With Dangerous Heart Rhythms
5. Ion channel responsible for pain identified by UB neuroscientists
6. Scientists decode secrets of a very common virus that can cause cancer
7. Scientists Spot Genetic Areas Key to Embryonic Development
8. UNC scientists discover potential strategy to improve cancer vaccines
9. Scientists Raise Fat-Burning Levels in Mice
10. Scripps Research scientists awarded $2.35 million to study new obesity treatment
11. NIH scientists identify mechanism responsible for spreading biofilm infections
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... Smiles by Stevens is pleased to ... facial wrinkling. While many patients are aware of the benefits of Botox® in the ... to those suffering with discomfort, soreness, and pain as a result of Jaw Tension, ...
(Date:11/25/2015)... ... November 25, 2015 , ... “While riding the bus, ... from Bronx, N.Y. “I thought there had to be a convenient and comfortable way ... , The PROTECTOR enables disabled individuals to safely travel during cold or inclement weather. ...
(Date:11/25/2015)... ... November 25, 2015 , ... Privately ... has undertaken significant expansion of its current state of the art research, development ... PharmaTech’s strategy to increase its manufacturing capacity as well as to support its ...
(Date:11/25/2015)... San Mateo, CA (PRWEB) , ... November 25, 2015 , ... ... $15,000 in prizes were awarded to winners of the Create Real Impact awards. ... and creative expression to help stem the tide of distracted and reckless driving, the ...
(Date:11/24/2015)... , ... November 24, 2015 , ... New patients who ... a referral for dental implants at her Mississauga, ON practice. Dr. Williams ... in the placement of dental implants. , Missing teeth can lead to a ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015  DILON Diagnostics and GE ... an agreement for DILON to distribute GE,s Discovery NM750b ... globe. The signing of this distribution agreement will provide Dilon,s ... Breast Imaging system and is considered an initial step ... healthcare solutions for clinicians and their patients. ...
(Date:11/24/2015)... Sectra (STO: SECT B) announces that ... agreement to deploy Breast Imaging PACS in its ... Breast Center a future-proof platform capable of expanding with the ... that Breast Center of Acadiana has entered into ... in its two freestanding imaging centers. This investment will ...
(Date:11/24/2015)... --  HeartWare International, Inc . (NASDAQ: HTWR ), ... that are revolutionizing the treatment of advanced heart failure, ... Doug Godshall is scheduled to present at the ... December 1, 2015 at 3:00 p.m. ET.  The conference ... York . .  A ...
Breaking Medicine Technology: