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VEGF may not be relevant biomarker for advanced prostate cancer
Date:4/29/2013

al, or biochemical failure.

What's more, there was no difference between the two treatment arms, those who had androgen therapy and radiation therapy and those who just had radiation. The median follow up time was for all surviving patients was 12.2 years.

"VEGF in this disease does not have a driver role," said Dr. Dicker. "The clinical trials using VEGF inhibitors did not have clinical benefit, so this study confirms that this is not a path forward to tacking this disease."

The results are not definitive statements about VEGF, the authors explain, but reporting on this well-characterized population with long-term follow is a significant contribution to the literature.

"This study is among the larger studies of VEGF expression in prostate cancer, and we urge the research community to avoid the misrepresentation of the literature with a lack of publication of even well-designed large negative studies, a publication bias against negative trials, as the current literature in this area appears to be predominated by only small exploratory positive trials, with a lack of subsequent confirmation with larger, longer prospectively designed trials," the authors write.

Other institutions included Prince Edward Island Cancer Treatment Centre, University of Pennsylvania, Abington Hospital, University of California, San Francisco, Melre M. Mahr Cancer Center, University of Miami, and the Intermountain Medical Center.


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Contact: Danielle Servetnick
danielle.servetnick@jefferson.edu
215-955-2238
Thomas Jefferson University
Source:Eurekalert

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