Navigation Links
VCU receives grant to study molecular marks left by childhood adverse experiences
Date:7/22/2014

Virginia Commonwealth University has received a five-year, $3 million grant to study how adverse experiences such as severe illnesses, neglect and maltreatment during childhood leave molecular marks in DNA that predict health risks later in life.

The Center for Biomarker Research and Personalized Medicine at the VCU School of Pharmacy, in collaboration with Duke University School of Medicine, will conduct the five-year study, which is funded by the National Institutes of Health, National Institute of Mental Health.

"Childhood adverse experiences such as severe illness, neglect or maltreatment have been robustly linked to psychiatric and other medical conditions where the consequences often persist far into adulthood," said Edwin van den Oord, Ph.D., director of the Center for Biomarker Research and Personalized Medicine and principal investigator on the study. "Our goal is to study how these early adverse experiences become biologically embedded and how they create long-term health risks."

"An accumulation of evidence from animal and human research implicates DNA methylation," said Karolina Aberg, Ph.D., associate director of the Center for Biomarker Research and Personalized Medicine. "Methylation is a process that involves small chemical changes to the DNA that can be the result of the environmental factors such as adverse events."

Aberg is responsible for the laboratory components of the project that involve measuring the methylation status of approximately 28 million possible sites in the human genome using the most recent high throughput sequencing technology.

The project capitalizes on a study started at Duke University about 20 years ago that involved 9- to 13-year-old children. That study continues today as the participants are in their 30s. Because detailed assessments and blood samples were obtained at two-year intervals, the investigators can compare DNA methylation profiles before and after adverse events
'/>"/>

Contact: Eric Peters
petersem@vcu.edu
804-828-0563
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Loyola Cancer Center receives Outstanding Achievement Award
2. MU receives national award for using mind-body approach to improve health
3. Neuropsychologist receives University of Houstons highest faculty honor
4. Boston researcher, surgical oncologist receives national award
5. LA BioMed receives Grand Challenges Explorations grant
6. Lawson researcher receives 1 of first-ever Pfizer Psychiatry Research Awards
7. Dr. Arthur Slutsky, vice-president of research at St. Michaels, receives lifetime award
8. UC San Diego Superfund Research Program receives $15 million grant renewal
9. Markey receives $6.25 million to study deadly blood and bone marrow disease
10. Feola, at University of Kentucky, receives NIH grant to study cystic fibrosis
11. UC Santa Barbaras Kavli Institute receives 2 grants to explore interface of physics and biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2015)... On Wednesday, May 20, 2015, CareFirst BlueCross ... the target of a sophisticated cyberattack,” and that it, ... Information Technology (IT) security efforts in the wake of ... notable attack on health insurers was reported in February ... largest health insurer, revealed that they had suffered a ...
(Date:5/23/2015)... A live auction will be held to ... centers and other medical facilities around the United States. ... radiology, surgery, anesthesia, exam and much more. , The ... May 28 starting at 9:00am CDT each day. The equipment ... Avenue, Melrose Park, IL 60160. Anyone can participate in ...
(Date:5/23/2015)... Injury lawyer Steven H. Heisler commented today ... the Maryland legislature but which has not been signed to ... HB 449 with overwhelming bipartisan support on April ... into law. This bill ensures that fracking is prohibited in ... the danger of fracking to our water supplies and the ...
(Date:5/22/2015)... 22, 2015 The American College of ... in June. They will hold a webinar on the ... two-day class on Classical Chinese Medicine. , Webinar – ... Steve Given, the Dean of Clinical Education, will lead ... First Professional Doctorate program. ACTCM is currently developing this ...
(Date:5/22/2015)... 2015 Hundreds of federal Xarelto ... individuals who allegedly experienced serious internal bleeding and ... move forward in the U.S. District Court, Eastern ... dated May 4, 2015, the Court has established ... stored information. Among other things, the Order sets ...
Breaking Medicine News(10 mins):Health News:One Headline Making Cyber Attack Sparks Discovery of Another 2Health News:One Headline Making Cyber Attack Sparks Discovery of Another 3Health News:One Headline Making Cyber Attack Sparks Discovery of Another 4Health News:Over 5,200 Lots of Medical Equipment Will Be Sold by Live Auction 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3Health News:ACTCM Announces Upcoming June Events 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 2Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 3Health News:Court Overseeing Federal Xarelto Lawsuits Establishes Procedures Governing Preservation of Documents, Electronically Stored Information 4
... of a Canadian study, a multivitamin pill should be ... reduce risks of having a child with birth defects.// ... of a wide range of severe birth defects like ... heart malformations, truncated or missing limbs, urinary-tract abnormalities and ...
... young, developing brains, according to researchers whose studies have ... IQ scores later in life. ,The association ... and hypertension is a well documented fact. ... the University of Florida said, "We're postulating that early-onset ...
... The New York Times says that breastfeeding in the US ... professional backgrounds// are allowed to breastfeed their babies, while poor ... to choose between feeding my baby the best food and ... Resorts Atlantic City Casino. She said she had to take ...
... Scientists from the Weizmann Institute's Plant Sciences Department conducted ... manage to survive in diverse climates like Antarctica and ... found that only two amino acids made a difference ... moderate temperatures or high degree of heat. The study ...
... attack, New York City's Health Department yesterday issued long-awaited ... It comprises medical advice that is supposed to be ... scattered across the United States. ,The guidelines ... illness resulting from 9/11 experiences was previously given by ...
... in the tears of a Jharkhand girl who complained that ... Institute of Medical Science (AIIMS) here Wednesday.// ,Savitri, a ... stones in her tears for the last two years. She ... ,"The initial investigation has not found any problem in her ...
Cached Medicine News:Health News:Prenatal multivitamins reduce birth defects 2Health News:Prenatal multivitamins reduce birth defects 3Health News:IQ of Toddlers Affected by Excess weight 2Health News:Bacteria Can Survive In Extreme Heat 2Health News:Medical Guidelines to treat 9/11-related illness 2
(Date:5/22/2015)... , May 22, 2015 Electrophysiologist Kevin ... recently traveled to Boston, MA ... the 2015 Heart Rhythm Society conference. These scientific ... focus on the ideas, people and technology that ... is a hybrid, minimally invasive cardiac operation that ...
(Date:5/22/2015)... May 22, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX), ... repair and regeneration, today announced that J.J. Finkelstein ... present a corporate overview at two upcoming investor conferences. ... SeeThruEquity 4 th Annual Microcap Conference on Thursday ... at 11:00 am EDT.  A webcast will ...
(Date:5/22/2015)... May 22, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: ... peer-reviewed publication of the results of the Company,s ... preservative-free eye drops) for the treatment of dry ... (CAE ® ) model.  The exploratory study was ... were previously disseminated by the Company in a ...
Breaking Medicine Technology:St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 2St. Joseph's Hospital Heart Institute Physician Presents at Heart Rhythm Society 3RegeneRx to Present at 2 Investor Conferences 2RegeneRx to Present at 2 Investor Conferences 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 2Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 3Complete Data from RegeneRx Phase II Dry Eye Trial Published in Current Issue of Clinical Ophthalmology 4
... Today the House passed H.R. 5651, its version ... including important provisions to mitigate drug shortages, most notably ... the world,s largest professional society concerned with the causes ... members who specialize in blood cancers such as leukemia, ...
... May 31, 2012 The Wolverine Venture Fund , ... H. Lurie Institute for Entrepreneurial Studies at the University ... invested in Sonitus Medical, a medical device company that manufactures ... sound via the teeth. The $25 million Series D round ...
Cached Medicine Technology:American Society of Hematology Statement on House Passage of Prescription Drug User Fee Act (PDUFA) 2University of Michigan's Wolverine Venture Fund Participates in $25 Million Series D Investment in Sonitus Medical 2University of Michigan's Wolverine Venture Fund Participates in $25 Million Series D Investment in Sonitus Medical 3
... Mesh is constructed of Bard polypropylene mesh, ... over 40 years. Developed with the world ... Preshaped Mesh takes the guesswork out of ... sugeon performs a Lichtenstein inguinal hernia repair ...
... The Modified Kugel patch repair is ... be completed through a small 4-6 cm ... a preperitoneal repair performed through an open, ... local or regional anesthesia.,The Modified Kugel patch ...
... technique, recommended for the treatment of ... direct inguinal hernias, provides significant advantages ... less overall dissection and is utilized ... The result is increased patient comfort, ...
... is constructed of knitted filaments of ... that used in PROLENE* Polypropylene Suture, ... The mesh is approximately,0.020 inches thick. ... suture, has been reported to be ...
Medicine Products: