Navigation Links
VCU findings may help explain some major clinical symptoms of preeclampsia

RICHMOND, Va. (Jan. 4, 2011) Virginia Commonwealth University School of Medicine researchers have found that a significant increase of an enzyme in the blood vessels of pregnant women with preeclampsia may explain some of the symptoms associated with the condition, including hypertension, swelling and protein in the urine.

The findings could lead to a treatment for pregnant women with preeclampsia, which is one of the most significant health problems in pregnancy and a leading cause worldwide of both premature delivery and of sickness and death of the mother and baby.

Preeclampsia, a condition which occurs in one out of 20 pregnancies, is diagnosed when the mother develops high blood pressure and starts losing protein in her urine after 20 weeks of pregnancy. Research has shown that the blood vessels of women with preeclampsia are dysfunctional, but the cause of preeclampsia is not known, and the only treatment is delivery of the baby.

In a study published in the January issue of The American Journal of Pathology, the VCU team reported a significant increase in an enzyme called MMP-1 in blood vessels of women with preeclampsia and an imbalance in collagen-regulating genes that favored the breakdown of collagen. MMP-1 is an enzyme produced in tissues under conditions of inflammation that acts to break down collagen.

"The increase in MMP-1 that we found would compromise the integrity of the mother's blood vessels, which could explain two of the clinical symptoms of preeclampsia edema and proteinuria," said corresponding author Scott Walsh, Ph.D., professor in the VCU Department of Obstetrics and Gynecology.

The swelling experienced by pregnant women with preeclampsia is due to edema, which is a leakage of protein out of the blood vessels into surrounding tissues. Proteinuria is a leakage of protein through the blood vessels of the kidney and into the urine.

The team also found that MMP-1 causes blood vessel contraction by activation of a receptor known as PAR1, which according to Walsh, could explain the hypertension, or high blood pressure, of women with preeclampsia.

"This finding may be especially important for preeclampsia because we found increased amounts of PAR1 in blood vessels of preeclamptic women as compared to normal pregnant women. MMP-1 activation of PAR1 is a totally new mechanism to explain hypertension," Walsh said.

PAR1 is best known for its role in the coagulation of blood, but it is not known for a role in hypertension, said Walsh.

Further, the team showed that neutrophils, or white blood cells, and neutrophil products increase MMP-1 and PAR1. According to Walsh, neutrophil infiltration may be the cause of the increase in MMP-1 and PAR1 in blood vessels that leads to vessel dysfunction and clinical symptoms of preeclampsia.

"Activation of the PAR1 receptor by MMP-1 causes changes in the endothelial cells of blood vessels that we speculated could result in contraction of blood vessels. This new information provides a rationale for the use of PAR1 inhibitors to treat preeclampsia," said Walsh.


Contact: Sathya Achia Abraham
Virginia Commonwealth University

Related medicine news :

1. Addiction research: Key findings every month
2. Encouraging findings suggest new avenues for treating liver disease in overweight Americans
3. Latest Findings Back Mammograms for Women in Their 40s
4. National committee releases findings on transforming and improving the nursing profession
5. Study findings show value of dietary supplement SAMe in treatment of adults with major depressive disorders
6. New findings further clarify breast cancer risk with hormone therapy
7. Mayo Clinic researchers share latest findings in CT radiation dose reduction efforts
8. U. Iowa biologists publish findings on cell interactions
9. Strong scientific findings presented at AIDS 2010 point to promise ahead and underscore the need to stay the course
10. Tel Aviv University Fertility Research Confirms New York Center's DHEA Findings
11. Fresh findings about chickenpox could lead to better blood tests
Post Your Comments:
(Date:11/24/2015)... , ... November 24, 2015 , ... With Thanksgiving right ... is sharing safety tips to help protect your family and vehicle. , According to ... the 2013 Thanksgiving holiday weekend. Amica is sharing the following safety tips from the ...
(Date:11/24/2015)... Abington, PA (PRWEB) , ... November 24, 2015 ... ... announce that it has been designated an Aetna Institute of Quality® Bariatric Surgery ... information about the quality and cost of health care services available to its ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... award for its exceptional customer service: the TrustDale certification. The award recognizes good ... Baltimore stone honing , tile and grout, and hard surface restoration company ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... Autism Speaks, ... the global movement driven by social media and the generosity of people around the ... encourage their social media networks to give – and share the personal stories behind ...
(Date:11/24/2015)... ... ... her life, Don Peck’s mother wondered if she was a descendant of Samuel Fuller, a ... a 25-year search for information, Don and his aunt discovered that she was not, in ... out, it was Don’s father who was descended from not one, but four passengers on ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015  In the pharmaceutical ... in an effort to quickly uncover new insights, tactics ... --> --> However, organizations ... market research project and ensure that all rules and ... industry standards. Another major barrier to efficiently launching market ...
(Date:11/24/2015)... , Nov. 24, 2015  DILON Diagnostics and GE ... an agreement for DILON to distribute GE,s Discovery NM750b ... globe. The signing of this distribution agreement will provide Dilon,s ... Breast Imaging system and is considered an initial step ... healthcare solutions for clinicians and their patients. ...
(Date:11/24/2015)... 2015   HeartWare International, Inc . (NASDAQ: ... support technologies that are revolutionizing the treatment of advanced ... Officer Doug Godshall is scheduled to present ... Conference on December 1, 2015 at 3:00 p.m. ET.  ... New York . ...
Breaking Medicine Technology: