Navigation Links
VCU Massey research finds new link between inflammation and cancer
Date:8/16/2010

Richmond, Va. (Aug.16, 2010) Virginia Commonwealth University Massey Cancer Center researchers have uncovered a new link between chronic inflammation and cancer. Although cancers do not always cause inflammation, chronic inflammation is known to help tumor cells grow.

In an article published in the June issue of Nature, VCU Massey scientists Sarah Spiegel, Ph.D., and Tomasz Kordula, Ph.D., and their co-authors examine how sphingosine-1-phosphate (S1P), a lipid mediator in the blood that influences immune cell circulation, also regulates inflammation and cancer. They reported that S1P is a missing cofactor that is required for the activity of TRAF2, the key regulator of NF-kappaB, which acts as a master on-off switch in controlling inflammation and cancer.

Spiegel, who is internationally recognized for her pioneering work on bioactive lipid signaling, discovered almost two decades ago that S1P is a potent lipid mediator that stimulates cell growth. S1P and the kinase that produces it, SphK1, have since emerged as critical regulators of numerous fundamental biological processes affecting health and disease.

"It is difficult to find an area of physiology and pathophysiology in which S1P does not have important if not key roles. Appropriate to its name, which is associated with the enigma of the Sphinx, how S1P so profoundly regulates cell fate decisions has long remained a mystery," said Spiegel, co-leader of VCU Massey's Cancer Cell Signaling Program and chair of VCU School of Medicine's Biochemistry and Molecular Biology Department.

The puzzle of how such a simple molecule as S1P can have diverse roles has been solved by VCU Massey researchers' discovery that this lipid mediator functions not only as a "first messenger," a ligand or agonist that binds to specific cell surface receptors, but also inside the cells as an "intracellular second messenger" that is required for activation of the transcription factor NF-
'/>"/>

Contact: Jenny Owen
jrowen2@vcu.edu
804-628-2111
Virginia Commonwealth University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Gulf Oil Spill Still a Health Threat to Many, Researchers Report
2. Researchers identify potential new target for ovarian cancer
3. How badly does it hurt? Research examines the biomedical diagnosis of pain
4. NSF awards stem cell bio-manufacturing research and education program to Georgia Tech
5. Amphetamine use increases risk of aortic tears in young adults, UT Southwestern researchers report
6. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
7. In NIH-funded study, researchers uncover step in brain events leading up to addiction
8. Adversity in childhood can increase risk of cardiovascular disease in adulthood, research shows
9. Mount Sinai leads Consortium of Food Allergy Research with $29.9 million grant
10. A*STAR and Institut Merieux/bioMerieux invest S$3m ($2.2m) in tuberculosis research
11. College Of Medicine receives $54 million grant for asthma research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
VCU Massey research finds new link between inflammation and cancer
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... SATURDAY, July 16 (HealthDay News) -- You may love the ... laze around outside, but don,t overdo it: Overexposure to the sun ... On average, heat waves kill more people each year in ... dies every hour from skin cancer, the most common type of ...
... Children who show fewer than normal signs of affection ... at risk for depression, a new study suggests. Although ... red flag for depression, too few demonstrations of happiness and ... with bad moods well, making them more vulnerable to depressive ...
... nurse staffing in California hospitals to similar hospitals in ... University of Pennsylvania School of Nursing have found that ... to the hospital staffing mix, not fewer as feared. ... legislation setting staffing levels. However, mindful of the ongoing ...
... , FRIDAY, July 15 (HealthDay News) -- One way to ... cutlery, a new study suggests. When eating out, people who ... who used a smaller utensil, according to findings released online in ... Journal of Consumer Research . , , In conducting the field ...
... The Berlin Institute for Medical Systems Biology (BIMSB) of ... Berlin, Germany, will be the first academic research institution ... enabling the sequencing of single DNA molecules in real ... faster than current high-throughput technologies. The researchers of the ...
... , FRIDAY, July 15 (HealthDay News) --,More than half of ... new survey finds. Cyberbullying, which usually means one teen ... peer online, has risen along with accessibility of the internet ... In a survey of more than 1,000 parents of ...
Cached Medicine News:Health News:Kids of Moms With History of Depression Seem Less Happy 2Health News:California nurse staffing 2Health News:Want to Eat Less? Try a Bigger Fork 2Health News:Novel DNA sequencer for MDC's systems biology 2Health News:Cyberbullying a Big Worry for Parents: Survey 2
(Date:12/22/2014)... 2014 Research and Markets ( ... "Investment Analysis of the US Medical Device ... http://photos.prnewswire.com/prnh/20130307/600769 ... device sector identifies the key trends and rationale ... and mergers and acquisitions. The study ...
(Date:12/22/2014)... , Dec. 22, 2014 Cyberonics, Inc. (NASDAQ: ... for the treatment and management of epilepsy, today announced it ... Healthcare Conference on Wednesday, January 14, 2015, in ... Cyberonics, President and Chief Executive Officer, will speak at 11:00 ... can be accessed by clicking on the Investor Relations link ...
(Date:12/22/2014)... 2014 /PRNewswire/ -- RXi Pharmaceuticals Corporation (NASDAQ: ... developing and commercializing innovative therapies addressing major unmet ... following open letter to shareholders from President & ... Dear RXi Shareholders, In ... statements posted on certain social media sites seem ...
Breaking Medicine Technology:Investment Analysis of the US Medical Device Sector 2RXi Pharmaceuticals Issues Open Letter to Shareholders 2RXi Pharmaceuticals Issues Open Letter to Shareholders 3RXi Pharmaceuticals Issues Open Letter to Shareholders 4RXi Pharmaceuticals Issues Open Letter to Shareholders 5RXi Pharmaceuticals Issues Open Letter to Shareholders 6
... Dec. 15, 2010 Pharmaceutical Institute, a leading ... and biotech industry and a subsidiary of Campbell ... Design Director.  In this role, Mr. Pienkowski will ... and commercially available courses within the industry,s largest ...
... 2010 TeleTracking Technologies and RTLS subsidiary RadarFind ... Ft. Lauderdale Hotel, January 13 & 14, 2011, ... cost savings achievable through better asset tracking and ... Hospital, Memorial University Medical Center, and the joint ...
Cached Medicine Technology:Pharmaceutical Institute Hires Nathan Pienkowski, Ph.D., to Head Instructional Design 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
CUSA DISSECTRON PORTABLE UNIT is an ultrasonic surgical aspirator for the fragmentation and emulsification of tissue available only outside the United States....
... The Surgical Foam Headrest automatically secures ... patient as comfortable as possible. Several ... adjust for any head size from ... be autoclaved when necessary. From surgical ...
... These focusing prismatic telescope are available in ... and 4.2x can be spectacle mounted or supplied ... The 8.25x is a hand held telescope. ,Small ... ideal for reading signposts, bus numbers, etc. ...
Medicine Products: