Navigation Links
VCU Massey research finds new link between inflammation and cancer
Date:8/16/2010

Richmond, Va. (Aug.16, 2010) Virginia Commonwealth University Massey Cancer Center researchers have uncovered a new link between chronic inflammation and cancer. Although cancers do not always cause inflammation, chronic inflammation is known to help tumor cells grow.

In an article published in the June issue of Nature, VCU Massey scientists Sarah Spiegel, Ph.D., and Tomasz Kordula, Ph.D., and their co-authors examine how sphingosine-1-phosphate (S1P), a lipid mediator in the blood that influences immune cell circulation, also regulates inflammation and cancer. They reported that S1P is a missing cofactor that is required for the activity of TRAF2, the key regulator of NF-kappaB, which acts as a master on-off switch in controlling inflammation and cancer.

Spiegel, who is internationally recognized for her pioneering work on bioactive lipid signaling, discovered almost two decades ago that S1P is a potent lipid mediator that stimulates cell growth. S1P and the kinase that produces it, SphK1, have since emerged as critical regulators of numerous fundamental biological processes affecting health and disease.

"It is difficult to find an area of physiology and pathophysiology in which S1P does not have important if not key roles. Appropriate to its name, which is associated with the enigma of the Sphinx, how S1P so profoundly regulates cell fate decisions has long remained a mystery," said Spiegel, co-leader of VCU Massey's Cancer Cell Signaling Program and chair of VCU School of Medicine's Biochemistry and Molecular Biology Department.

The puzzle of how such a simple molecule as S1P can have diverse roles has been solved by VCU Massey researchers' discovery that this lipid mediator functions not only as a "first messenger," a ligand or agonist that binds to specific cell surface receptors, but also inside the cells as an "intracellular second messenger" that is required for activation of the transcription factor NF-kappaB.

These findings also provide an explanation for the numerous observations of the importance of the enzyme that produces S1P, SphK1, in protection of cancer cells against chemotherapeutic drugs and the correlation of its levels with poor prognosis of many types of cancers, including breast, colorectal and brain.

Spiegel hopes that specific SphK1 inhibitors they are developing will pave the way for future potent and specific drugs that target SphK1 for the treatment of cancer.


'/>"/>

Contact: Jenny Owen
jrowen2@vcu.edu
804-628-2111
Virginia Commonwealth University
Source:Eurekalert  

Related medicine news :

1. Gulf Oil Spill Still a Health Threat to Many, Researchers Report
2. Researchers identify potential new target for ovarian cancer
3. How badly does it hurt? Research examines the biomedical diagnosis of pain
4. NSF awards stem cell bio-manufacturing research and education program to Georgia Tech
5. Amphetamine use increases risk of aortic tears in young adults, UT Southwestern researchers report
6. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
7. In NIH-funded study, researchers uncover step in brain events leading up to addiction
8. Adversity in childhood can increase risk of cardiovascular disease in adulthood, research shows
9. Mount Sinai leads Consortium of Food Allergy Research with $29.9 million grant
10. A*STAR and Institut Merieux/bioMerieux invest S$3m ($2.2m) in tuberculosis research
11. College Of Medicine receives $54 million grant for asthma research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
VCU Massey research finds new link between inflammation and cancer
(Date:1/20/2017)... ... ... “I Forgive You”: a fine examination of how God handles sin, including how to ... author, Stephen Miller, who, for over ten long years has been waiting to release this ... and Tobago, he has been serving the Lord for over twenty years, and he has ...
(Date:1/20/2017)... ... ... “The Land of More and More”: a brilliant story for children ... the simple and achievable answer. “The Land of More and More” is the creation ... in Angola, Indiana where he works with the children’s ministry department. , Michael ...
(Date:1/19/2017)... ... 2017 , ... Wells Pharmacy Network announced the completion of ... pharmacy located in Ocala, Florida. , Meeting the Needs of a Growing ... States for high-quality human anti-aging and wellness compounded medications, Wells Pharmacy ...
(Date:1/19/2017)... ... January 19, 2017 , ... Remote Medical Technologies ... impressive transportable capabilities with their iMedHD2™ Portable Teleultrasound System. Compatible ... technology that delivers HD, dynamic, streaming ultrasound images and video to one or ...
(Date:1/19/2017)... ... January 19, 2017 , ... MB Business Capital, ... $11,250,000 senior credit facility to Sunrise, Florida-based Management Health Systems, LLC, dba MedPro ... facilitate a recapitalization of MedPro led by Harren Equity Partners. Brightwood Capital ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Fla. , Jan. 19, 2017  Sensus ... medical device company specializing in the treatment of ... as keloids, with superficial radiation therapy, today announced ... full year 2016 financial results on Thursday, February 2, ... Company will hold a conference call with the ...
(Date:1/19/2017)... , January 19, 2017 ... announced that the U.S. Food and Drug Administration (FDA) ... a New Drug Application (NDA) for SHP465, a long-acting, ... as a potential once-daily treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). ... or around June 20, 2017, the designated Prescription Drug ...
(Date:1/19/2017)... January 19, 2017 Pfizer ... the Milner Therapeutics Consortium   Major ... Cambridge   The Milner ... PFE ) as a partner to the Milner Therapeutics ... enables the efficient transfer of materials between industry and ...
Breaking Medicine Technology: