Navigation Links
VCU Massey research finds new link between inflammation and cancer
Date:8/16/2010

Richmond, Va. (Aug.16, 2010) Virginia Commonwealth University Massey Cancer Center researchers have uncovered a new link between chronic inflammation and cancer. Although cancers do not always cause inflammation, chronic inflammation is known to help tumor cells grow.

In an article published in the June issue of Nature, VCU Massey scientists Sarah Spiegel, Ph.D., and Tomasz Kordula, Ph.D., and their co-authors examine how sphingosine-1-phosphate (S1P), a lipid mediator in the blood that influences immune cell circulation, also regulates inflammation and cancer. They reported that S1P is a missing cofactor that is required for the activity of TRAF2, the key regulator of NF-kappaB, which acts as a master on-off switch in controlling inflammation and cancer.

Spiegel, who is internationally recognized for her pioneering work on bioactive lipid signaling, discovered almost two decades ago that S1P is a potent lipid mediator that stimulates cell growth. S1P and the kinase that produces it, SphK1, have since emerged as critical regulators of numerous fundamental biological processes affecting health and disease.

"It is difficult to find an area of physiology and pathophysiology in which S1P does not have important if not key roles. Appropriate to its name, which is associated with the enigma of the Sphinx, how S1P so profoundly regulates cell fate decisions has long remained a mystery," said Spiegel, co-leader of VCU Massey's Cancer Cell Signaling Program and chair of VCU School of Medicine's Biochemistry and Molecular Biology Department.

The puzzle of how such a simple molecule as S1P can have diverse roles has been solved by VCU Massey researchers' discovery that this lipid mediator functions not only as a "first messenger," a ligand or agonist that binds to specific cell surface receptors, but also inside the cells as an "intracellular second messenger" that is required for activation of the transcription factor NF-kappaB.

These findings also provide an explanation for the numerous observations of the importance of the enzyme that produces S1P, SphK1, in protection of cancer cells against chemotherapeutic drugs and the correlation of its levels with poor prognosis of many types of cancers, including breast, colorectal and brain.

Spiegel hopes that specific SphK1 inhibitors they are developing will pave the way for future potent and specific drugs that target SphK1 for the treatment of cancer.


'/>"/>

Contact: Jenny Owen
jrowen2@vcu.edu
804-628-2111
Virginia Commonwealth University
Source:Eurekalert  

Related medicine news :

1. Gulf Oil Spill Still a Health Threat to Many, Researchers Report
2. Researchers identify potential new target for ovarian cancer
3. How badly does it hurt? Research examines the biomedical diagnosis of pain
4. NSF awards stem cell bio-manufacturing research and education program to Georgia Tech
5. Amphetamine use increases risk of aortic tears in young adults, UT Southwestern researchers report
6. Researchers find function of proteins that can enhance the progression of viruses and cancer cells
7. In NIH-funded study, researchers uncover step in brain events leading up to addiction
8. Adversity in childhood can increase risk of cardiovascular disease in adulthood, research shows
9. Mount Sinai leads Consortium of Food Allergy Research with $29.9 million grant
10. A*STAR and Institut Merieux/bioMerieux invest S$3m ($2.2m) in tuberculosis research
11. College Of Medicine receives $54 million grant for asthma research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
VCU Massey research finds new link between inflammation and cancer
(Date:2/5/2016)... , ... February 05, 2016 , ... The event is ... Day Block Event Center in Minneapolis, Minn. Triumph Over Parkinson’s will fund nearly $100,000 ... owner of Schneiderman’s Furniture, lives with Parkinson’s disease and is the architect of this ...
(Date:2/5/2016)... ... 05, 2016 , ... Freed-Hardeman University President Joe A. Wiley ... joint enrollment and degree completion agreement. The agreement, which begins with the ... FHU|Dickson. , The agreement allows students to be jointly admitted to both ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... franchises from across the country gathered at the La Valencia Hotel in San ... PROSHRED Chicago was named the year’s most outstanding franchise, walking away with ...
(Date:2/5/2016)... ... ... Boar’s Head Brand®, one of the nation’s leading providers of premium delicatessen ... stress out of your party preparation – follow these easy, yet delicious recipes with ... game. , “The key to hosting a successful game-day party is creating a flavorful ...
(Date:2/5/2016)... ... ... Stuart Bentkover, MD, FACS is thrilled to announce the arrival ... tattoo removal today, Dr. Bentkover is the only doctor in Central Massachusetts to offer ... been approved by the Food and Drug Administration (FDA) as a safe and efficient ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016 Dehaier Medical ... or the "Company"), which develops, markets and sells ... China and international markets, ... which aims to concentrate the Company,s resources to ... respiratory business and to focus more on its ...
(Date:2/5/2016)... Site Profile: --> Site ... People, announced their latest primary healthcare case study where speech recognition ... and to save the practice money. Site Profile: ... Challenge: --> ,- Wirral CCG ,- VoicePower client since ... Wirral CCG ,- VoicePower client since 2013 Challenge: ...
(Date:2/4/2016)... Feb. 4, 2016  Edwards Lifesciences Corporation (NYSE: ... structural heart disease and critical care monitoring, announced today ... (ASR) agreement with Morgan Stanley & Co. LLC to ... is part of the Company,s previously authorized program to ... stock.  --> --> ...
Breaking Medicine Technology: