Navigation Links
VCU Massey first to combine targeted agents to kill multiple myeloma cells
Date:2/10/2011

Richmond, Va. (Feb. 10, 2011) Scientists at Virginia Commonwealth University Massey Cancer Center have developed a novel treatment strategy for multiple myeloma that pairs two targeted agents to kill cancer cells. The study's findings, published in today's edition of the journal "Blood," are the first to demonstrate the synergistic, anti-myeloma effects of this combination regimen both in vitro and in vivo.

Multiple myeloma is a cancer involving antibody-producing cells in the bone marrow, and, in most cases, is incurable. Targeted therapies work by interfering with biological and biochemical functions critical for cancer cell survival and proliferation. The new treatment strategy from VCU Massey combines Src inhibitors, which block the activity of an important group of proteins that regulate cancer cell behavior, with Chk1 inhibitors, which interfere with cancer cells' ability to undergo cell cycle arrest and repair DNA damage.

"Chk1 inhibitors are currently used primarily in conjunction with conventional DNA-damaging chemotherapeutic agents," says the study's lead investigator Steven Grant, M.D., associate director for translational research, Shirley Carter and Sture Gordon Olsson Chair in Oncology Research and professor of internal medicine at VCU Massey Cancer Center. "By combining Chk1 inhibitors with another targeted agent, such as Src inhibitors, we were able to induce cell death in multiple myeloma cells while sparing healthy, normal cells."

When multiple myeloma cells are subjected to DNA-damaging agents, or even when they are undergoing normal DNA replication, their DNA is subject to breakage. To survive, they must slow down their progression through the cell cycle in order to repair the DNA, or, if the damage is too severe, undergo a form of cell suicide.

Chk1 is an enzyme that allows cells to undergo cell cycle arrest, a process required to repair the DNA damage. When cancer cells are exposed to Chk1 inhibitor
'/>"/>

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Novel therapy for metastatic kidney cancer developed at VCU Massey Cancer Center
2. VCU Massey Cancer Center awarded $2.4 million grant from Virginia Tobacco Commission
3. Key leukemia defense mechanism discovered by VCU Massey Cancer Center
4. VCU Massey research finds new link between inflammation and cancer
5. When first-time mothers are induced, breaking the amniotic membrane shortens delivery time
6. First Look at Prostate Cancer Genome Yields Insights
7. First Lady Says President Obama Has Quit Smoking
8. FDA Approves First Pacemaker Deemed Safe During MRIs
9. FDA Approves First Drug to Prevent Premature Births
10. HPV vaccine works for boys: Study shows first clear benefits
11. UofL awarded $9.56 million to form first-ever multicenter cardiovascular research network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 Rockynol Retirement Community ... Oct. 14. The $11 million project will include the ... cooked-to-order kitchen with full-service restaurant style dining. , “We ... first class Assisted Living apartments,” said Kara Hanzie, Rockynol ... highest quality of care and this investment is proof ...
(Date:10/20/2014)... Unveiled at the Sept. 18 board meeting, The ... member hospital ROI on membership dues at 12.5. In other ... $12.50 in value to member hospitals. The calculation used to ... Dues. , “This is the first time we’ve actually ... the methodology is really sound,” said Bill Ryan , ...
(Date:10/19/2014)... October 20, 2014 Hastings and Hastings, ... years of service throughout the greater Phoenix area and ... representation with regard to catastrophic automobile accidents. Statistics have ... country and throughout Arizona. As such, Hastings and Hastings ... legal representation for those who have been injured through ...
(Date:10/19/2014)... working in the garment industry for decades, LunaDress’ dress specialists ... one of the company’s top designers, many ladies like prom ... add beauty to them. Chiffon floor length outfits are also ... selection of 2014 long prom dresses. , As a ... in over 20 popular designs. The company intends to meet ...
(Date:10/19/2014)... 2014 Stephen T. Greenberg, M.D., with offices ... the 10th consecutive year as one of Long Island’s best ... also been nominated as the best provider for Botox injections. ... best Day Spa and best Laser Treatment center on Long ... readers can vote for the contest once per day, per ...
Breaking Medicine News(10 mins):Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2Health News:Dr. Stephen T. Greenberg – Nominated for the 10th Consecutive Year for One of Long Island’s Best Cosmetic Surgeons for 2015 by the Long Island Press 2
... Financial Flexibility for their Purchase of Niobe(R) Magnetic Robotic ... 12 Stereotaxis, Inc. (Nasdaq: STXS ) ... Relational Technology Solutions (RTS) that will allow the Company ... for their purchase of Stereotaxis Niobe(R) magnetic robotic systems. ...
... Inc.,(NYSE: WX ), a leading pharmaceutical, biotechnology ... and the United States, today,announced that it will release ... 2009 Shanghai time, and after the US market close ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ) , ...
... Conference on Customer and Information Technology Support will be held in Las ... how organizations can communicate with their non-English speaking customers in 150 languages. ... ... service, support and help desk professionals from across the world will gather ...
... Alonso LLP is offering free consultations to Florida homeowners, associations ... defective Chinese drywall. , ... (PRWEB) ... free consultations to Florida homeowners, associations and condominium associations in ...
... and strong throughout MinnesotaMINNEAPOLIS, March 12 A ... that an overwhelming majority (72 percent) of Minnesotans ... respondents said the primary reason for their support ... quit and prevent kids from becoming smokers, and ...
... HAYWARD, Calif., March 11 Solta Medical, Inc. (Nasdaq: ... market, today announced that Silicon Valley Bank, a member company ... provided the company with a $9 million credit facility. ... strengthens our ability to pursue our strategic initiatives in the ...
Cached Medicine News:Health News:Stereotaxis Signs Agreement With Leading Leasing Specialist to Offer Alternative Financing to Hospital Customers 2Health News:Stereotaxis Signs Agreement With Leading Leasing Specialist to Offer Alternative Financing to Hospital Customers 3Health News:WuXi PharmaTech Schedules Fourth Quarter 2008 Earnings Release on Thursday, March 26, 2009 2Health News:LLE to Deliver Language Interpretation and Translation Solutions at Annual Customer Support Conference 2Health News:LLE to Deliver Language Interpretation and Translation Solutions at Annual Customer Support Conference 3Health News:Defective Chinese Drywall Lawsuit: Florida Homeowners' Associations and Condominium Associations Plagued by Defective Chinese Drywall Urged to Investigate their Rights 2Health News:Defective Chinese Drywall Lawsuit: Florida Homeowners' Associations and Condominium Associations Plagued by Defective Chinese Drywall Urged to Investigate their Rights 3Health News:New Poll: 72 Percent of Minnesotans Support Tobacco Tax Increase 2Health News:New Poll: 72 Percent of Minnesotans Support Tobacco Tax Increase 3Health News:Solta Medical, Inc. Secures $9M Credit Facility from Silicon Valley Bank 2
(Date:10/20/2014)...   Mary,s Medicinals today announced that its ... Sponsor of Operation Grow4Vets , a national, nonpartisan ... and services to assist them in living with injuries ... , An ever-increasing number of medical studies ... treatment for pain, Post-traumatic Stress Disorder (PTSD) and Traumatic ...
(Date:10/20/2014)... NEW YORK and RALEIGH, N.C., Oct. 20, ... the Hereditary Neuropathy Foundation (HNF), both philanthropies, announced ... develop drug candidates for the treatment of the ... BioPontis Alliance announced its alliance model ... is a first demonstration of a collaborative model ...
(Date:10/19/2014)... Oct. 20, 2014 CTI BioPharma Corp. (CTI) ... report its third quarter 2014 financial results on Wednesday, ... financial markets. Following the announcement, members of the management ... the results and provide a general corporate update at ... event can be obtained as follows: Wednesday, ...
Breaking Medicine Technology:Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 3The Hereditary Neuropathy Foundation and BioPontis Alliance for Rare Disease Partner to Develop Treatments for Charcot-Marie-Tooth 2The Hereditary Neuropathy Foundation and BioPontis Alliance for Rare Disease Partner to Develop Treatments for Charcot-Marie-Tooth 3CTI BioPharma to Report Third Quarter 2014 Financial Results on October 29, 2014 2
... and additional analyses from the Phase II portion of ... relaxin for the treatment of acute heart failure will ... meeting of the Heart Failure Association of the European ... M.D., professor of cardiology at the University of Brescia, ...
... Breast Cancer and Melanoma Studies - Conference Call to ... am BRANFORD, Conn., May 28 CuraGen Corporation ... for three data presentations from its ongoing clinical trials ... patients with advanced breast cancer and melanoma at the ...
Cached Medicine Technology:Results and Additional Analyses From Efficacy and Safety Study of Corthera's Relaxin in Acute Heart Failure to be Presented at Heart Failure Congress 2009 2CuraGen to Present CR011-vcMMAE Data at ASCO 2CuraGen to Present CR011-vcMMAE Data at ASCO 3CuraGen to Present CR011-vcMMAE Data at ASCO 4CuraGen to Present CR011-vcMMAE Data at ASCO 5
Near PT test card/illus of the ocular adnexa 5 1/2" X 8"....
Near point card/newspaper 8 to 48 point type 5 1/2" X 8"....
Near and far chart set provides letter and number matrix for testing and accommodative vision training. Set includes 1-8 1/2 X 11 chart on white card with black print and 2-3X5 laminated white card w...
... provides references to many common print sizes, from ... size. This provides the examiner a starting point ... with black ink on yellow styrene for increased ... 20/20. Other notations include Jaeger, M notation, lower ...
Medicine Products: