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VCU Massey Cancer Center spearheads novel clinical study for lymphoma patients
Date:9/2/2008

The Virginia Commonwealth University Massey Cancer Center recently opened a National Cancer Institute (NCI)-sponsored, phase II clinical study for certain sub-types of non-Hodgkin's lymphoma.

The study is based on research from VCU Massey Cancer Center as well as other centers suggesting that combining two novel, recently approved drugs that have shown effectiveness in certain blood cancers may be active in patients with diffuse large B-cell lymphoma, or mantle cell lymphoma. The study is intended for patients whose disease has progressed following treatment with other regimens.

Other NCI centers participating in this novel lymphoma study through the NCI's Southeast Phase II Consortium include H. Lee Moffitt Cancer Center and Research Institute (Tampa, Fla.), which is the coordinating center; the University of North Carolina Lineberger Comprehensive Cancer Center (Chapel Hill, N.C.); and the Vanderbilt-Ingram Cancer Center (Nashville, Tenn.). Also planning to participate are Montefiore-Einstein Cancer Center (New York); and New York Presbyterian Hospital / Weill Cornell Medical College, both of which are in the NCI-sponsored New York Phase II Consortium.

The investigators hope to learn whether these types of lymphoma respond to treatment with the combination of bortezomib, marketed as Velcade, and vorinostat, marketed as Zolinza. They also intend to learn about the side effects of this drug regimen and whether certain features of these lymphomas might predict for response to this regimen.

Steven Grant, M.D., principal investigator of the study and associate director for translational research at VCU Massey Cancer Center, is among a number of researchers worldwide who have reported synergistic interactions between proteasome inhibitors such as bortezomib and histone deacetylase inhibitors such as vorinostat in leukemia and other hematologic malignancies. Other cancer centers are currently exploring this drug combination in
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Contact: Andrea Butler
albutler@vcu.edu
804-628-2111
Virginia Commonwealth University
Source:Eurekalert

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