Navigation Links
VBI, Mayo Clinic investigate link between fungal proteins, innate immunity and asthma
Date:2/27/2008

re being attacked by parasites. Environmental fungi such as Alternaria do not typically cause invasive infections like parasites but for some reason, in certain people, the body thinks it is being attacked. This results in Th2 cells constantly recruiting eosinophils and chronic inflammation occurs because humans are continually exposed to common environmental fungi like Alternaria.

The hypothesis that will be tested is that certain immunoactive enzymes from Alternaria activate dendritic cells through yet unidentified receptors that allow for tailoring of the adaptive immune response and the formation of Th2 cells. This in turn leads to the strong immune responses in the airways. The research team will use different approaches to determine the potential role of these receptors in the cascade of immune interactions that comprise inflammation of the airways. This should allow them to better understand how certain environmental stimuli are linked via the innate immune system to the adaptive immune system and development of inflammation and disease.

Dr. Chris Lawrence, Associate Professor at VBI and the Department of Biological Sciences at Virginia Tech, one of the leading experts in Alternaria biology and principal investigator of the Alternaria genome sequencing project funded by the National Science Foundation-United States Department of Agriculture (NSF-USDA) Microbial Genome Sequencing Program, stated: Our part of the collaboration is critical and will involve the use of proteomics and functional genomics approaches to identify the novel enzymes produced by Alternaria that are triggers of innate immune responses that shape the adaptive immune system. Recombinant fungal proteins will be used to dissect the different molecular steps involved in the development and progression of inflammation and asthma. He added: We will create a series of fungal knockout mutants for specific genes that will be used to examine the specific role of fungal proteins
'/>"/>

Contact: Barry Whyte
whyte@vbi.vt.edu
540-231-1767
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Does artificial intelligence help clinicians to recognize atrophic gastritis with thyroid disease?
2. HealthpointCapital, LLC Appoints Stephen H. Hochschuler, M.D. as Clinical Advisor
3. Daniel Magilavy, M.D. Joins Rigel as Vice President of Clinical Research
4. Pharsight to Present at eClinical Forum
5. PRA International to Open Expanded Clinical Pharmacology Center
6. Elsevier enhances clinical decision making with suite of Clinical Decision Support solutions
7. Hyperion Therapeutics Announces Enrollment of First Patient in Phase 2 Clinical Trial in Patients With Hepatic Encephalopathy
8. Professional Products, Inc. Integrates Clinical Skills and Simulation Center at the Johns Hopkins Hospital
9. Algeta Receives IND Approval for Alpharadin(TM) to Commence Clinical Development in the USA
10. Cleveland Clinic Collaborates with Google
11. Derma Sciences Announces Several Clinical Presentations on MEDIHONEY(TM) Wound & Burn Dressings at Upcoming APWCA Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... “Cluster headaches are sometimes called ‘Suicide Headaches’ because ... said Steve Young of Ew Publishing; “I’ve had cluster ... is more intense.” , “It should be a relief ... that medical research is pointing to some relief and ... Serotonin (5-HT, 5-hydroxytryptamine) is a ubiquitous biochemical found in ...
(Date:9/21/2014)... Mills, Md. (PRWEB) September 21, 2014 Faculty ... school with a coed preschool in Owings Mills, Md., kicked ... wellness with Garmin Vivofit bands. GFS is the first independent ... steps taken, calories burned and even sleep patterns— as part ... a Baltimore area running and walking specialty chain. The Vivofit ...
(Date:9/21/2014)... Top10BestSEOHosting.com, a leading review website, has recently announced ... most recommended hosting suppliers for the webmasters worldwide ... , “Don’t waste your time on searching ... hosting companies to you,” the IT manager of ... are the most recommended suppliers for everyone. A ...
(Date:9/20/2014)... Las Vegas, NV (PRWEB) September 21, 2014 ... created by Dr. Kenneth Pullman that is helping thousands ... reverse their diabetes symptoms without shots, pills, or prescriptions ... investigative review. , “There are currently tens of ... with both Type 1 and Type 2 diabetes, and ...
(Date:9/20/2014)... September 20, 2014 David Cooke presented ... The first poster looked at the clinical benefits of ... for calculating diastolic function. In conjunction with colleagues at ... disease and normal LVEF by echo (>50%). Each patient ... and standard SPECT. Emory Toolbox 4.0 was ...
Breaking Medicine News(10 mins):Health News:Homeostasis: Equinox Serotonin (5HT) Headache Stories ~ New on the Bryan William Brickner Blog 2Health News:Garrison Forest School Leader in Independent School Wellness Programs 2Health News:Leading Review Website Top10BestSEOHosting.com Unveils The Best Hosting Suppliers In September 2Health News:Diabetes Protocol: Review Exposes Kenneth Pullman’s Breakthrough Discovery About Diabetes Management 2Health News:Versatility of Emory Toolbox 4.0 Shown at ASNC in Scientific Posters 2Health News:Versatility of Emory Toolbox 4.0 Shown at ASNC in Scientific Posters 3
... Medco Health,Solutions, Inc. (NYSE: MHS ) is ... On Monday, March 17, 2008, Timothy C. Wentworth, ... Medco,s specialty pharmacy,subsidiary, is scheduled to address the 28th ... the Boston Marriott Copley,Place will begin at 1:45 p.m. ...
... may not be getting them, study says , , MONDAY, March ... dictate treatment choices for kidney cancer more than clinical factors ... new study finds. , This means many patients who ... partial nephrectomy where only part of the kidney is removed, ...
... A novel drug that fully eliminated brain tumors from ... darker sidecausing permanent bone damage in younger mice. The ... finding raises concerns about using similar drugs to treat ... thorough understanding of possible risks. , Tom Curran, Ph.D., ...
... for osteoporosis or who do not respond to treatment ... affects their quality of life. There is an ... address their issues when new therapies are assessed and ... Professor Cyrus Cooper from the MRC Epidemiology Resource Centre, ...
... Inc. (Nasdaq: PBIO ) today announced that ... Avenue in South Easton, Massachusetts. This,move was necessary ... and development company to a fully commercial,operation. Richard ... now have approximately 5,500 square feet, with sufficient,office, ...
... Gentiva Health,Services, Inc. (Nasdaq: GTIV ), the ... that it is scheduled to,present from 8:30 a.m. to ... Brothers Eleventh Annual Global Healthcare Conference in Miami,Florida., ... a live audio web cast,which may be accessed by ...
Cached Medicine News:Health News:Medco to Present at Cowen and Company and Lehman Brothers Health Care Conferences 2Health News:Surgeon's Preferences Dictate Choice of Kidney Cancer Surgery 2Health News:Surgeon's Preferences Dictate Choice of Kidney Cancer Surgery 3Health News:Potential brain cancer drug for children may damage bones 2Health News:Potential brain cancer drug for children may damage bones 3Health News:Make or break time for osteoporosis treatment 2Health News:Pressure BioSciences, Inc. Announces Move to New Corporate Offices 2Health News:Gentiva(R) Health Services to Present March 18th at Lehman Brothers Eleventh Annual Global Healthcare Conference in Miami 2Health News:Gentiva(R) Health Services to Present March 18th at Lehman Brothers Eleventh Annual Global Healthcare Conference in Miami 3
(Date:9/19/2014)... 19, 2014  Alere Inc. (NYSE: ALR ... following statement today in support of President Barack ... "As the global leader in rapid diagnostics for infectious ... strategy to address the serious threat of antibiotic resistance. ... Administration on initiatives to promote the development of rapid ...
(Date:9/19/2014)... LONDON , September 19, 2014 ... hat Pharma IQ den äußerst erfolgreichen Serialisierungs-Countdown-Kalender aktualisiert, ... abdeckt. Die interaktive PDF, verfügbar unter pharmaserialisation.com ... an dem sie jeweils in Kraft treten. ... der Serialisierung nicht länger um das "ob", sondern ...
(Date:9/19/2014)... Reductions in kidney failure obtained ... people with diabetes type 2 "Intensive treatment ... the kidneys." Australian researchers have discovered that ... leads to persistent reductions in kidney failure many years ... study has found that, five and a half years ...
Breaking Medicine Technology:Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2Pharma IQ stellt weltweite Serialisierungsfristen in seinen Countdown-Kalender 2014 - 2018 2ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 2ADVANCE-ON Post-trial Observational Study: Blood Pressure Arm and Glucose Arm Results 3
... Pharmaceutical Research and Manufacturers of America (PhRMA) President and CEO John ... Watch the Video "Congratulations ... campaign trail to earn the trust and votes of the American ... the state of our economy and jobs. "There ...
... HOPKINTON, Mass., Nov. 3, 2010 ... ), a leading provider of tools and services ... announced a collaboration with Sony DADC Austria AG ... for Caliper,s next generation microfluidics products. The agreement ...
Cached Medicine Technology:PhRMA CEO John Castellani Responds to Mid-Term Election, Stresses Importance of Innovation to Help Grow Economy 2PhRMA CEO John Castellani Responds to Mid-Term Election, Stresses Importance of Innovation to Help Grow Economy 3Caliper Life Sciences and Sony DADC Collaborate to Develop Plastic Microfluidic Solutions 2
The Electric H-Base Table is for heavier instruments, or for those who prefer electric elevation. The electric table easily accepts a slit lamp, a single tabletop, or a double tabletop, just as the M...
The Manual Table Base is elevated with an easy to reach elevating wheel for smooth operation. The table base will accept a slit lamp, a single table top, or a double tabletop for more than one instru...
A new, innovative design compliments the proven, 30-year mechanical operating system....
The Encore Stand combines the proven mechanical structure and durability of the popular Deluxe Stand, with a modern, sophisticated appearance....
Medicine Products: