Navigation Links
VARI findings may help patients with deadly kidney cancer
Date:2/18/2010

Grand Rapids, Mich. (Feb. 17, 2010) Van Andel Research Institute (VARI) researchers have found a way to reverse resistance to sunitinib, a treatment that is currently the first line of defense against clear cell renal cell carcinoma (ccRCC), a deadly form of kidney cancer. Most patients who show a positive response to sunitinib develop a resistance to the drug after one year of treatment.

Kidney cancer is among the 10 most common cancers in both men and women, striking nearly 50,000 Americans in 2009 and killing more than 11,000. Renal cell carcinoma (RCC) accounts for 9 out of 10 kidney cancers, and ccRCC is the most common subtype, accounting for 8 out of 10 RCC cases.*

"The research from Dr. Teh's (VARI) group is a critical step forward in understanding the mechanisms of response and resistance to the new standard of care therapies in renal cell carcinoma such as sunitinib," said Brian Rini, MD, Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute.

Sunitinib received FDA approval in 2006 and is a standard of care for both ccRCC and gastrointestinal stromal tumors. The drug is being investigated as a possible therapy for other cancers, including breast cancer, colorectal cancer, and non-small cell lung cancer.

Researchers found that ccRCC tumor cells that had developed a resistance to sunitinib had increased secretion of the protein interleukin-8 (IL-8). Administering sunitinib and IL-8 neutralizing antibodies re-sensitized tumors to sunitinib treatment. Researchers also found that IL-8 may serve as a useful biomarker to predict patients' response to sunitinib treatment.

"The development of ccRCC resistance to sunitinib treatment is of major clinical concern," said VARI Distinguished Scientific Investigator Bin Tean Teh, M.D., Ph.D., whose laboratory published its findings in this month's issue of Cancer Research. "It is now of critical importance to validate these findings in the clinical setting."

Another study from Teh's laboratory also published in Cancer Research this month looked into exactly how sunitinib works. The study found that the treatment does not target tumor cells, but rather the tumor's blood supply.

"Understanding how sunitinib works should have important implications for the improved treatment of ccRCC and perhaps other cancers as well," said VARI Postdoctoral Fellow Dan Huang, Ph.D., lead author of both studies.

"These insights will help build upon recent advances to extend clinical benefits to more patients with metastatic kidney cancer," said Dr. Rini.


'/>"/>

Contact: Joe Gavan
joe.gavan@vai.org
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Related medicine news :

1. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. New Report and Survey Findings Highlight Why More Women Die From Heart Disease Than Men
4. Gene Findings in Autism, Blindness at Childrens Hospital Top National Lists of Medical Advances in 2009
5. Are manometric findings different between the patients with erosive and nonerosive disease?
6. New Gene Findings Will Help Guide Treatment in Infant Leukemia
7. Northern California Cancer Centers Findings on Breast Cancer and Secondhand Smoke Released Internationally by the American Association for Cancer Research
8. The Leukemia & Lymphoma Society Available to Comment on Findings Presented at American Society of Hematology Conference
9. New findings suggest strategy to help generate HIV-neutralizing antibodies
10. Findings that should speed the development of drugs for Parkinsons disease
11. Shire Reports Findings From an Analysis Examining Emotional Lability in Children With ADHD Taking Vyvanse(R) (lisdexamfetamine dimesylate) Capsules CII
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... , ... April 29, 2016 , ... Spine Team Texas, ... is proud to announce one of their physicians has been invited to be a ... (Texas ACOFP) Family Practice Review conference on April 30, 2016. , Dr. R. ...
(Date:4/29/2016)... New York, NY (PRWEB) , ... April 29, ... ... integrated manufacturer and engineer of patented products, announces the Gyrociser, an exercise invention ... industry is worth $2 billion," says Scott Cooper, CEO and Creative Director of ...
(Date:4/29/2016)... ... , ... Dr. Robert Mondavi, one of the dentists in Torrance , ... fast-growing field as more patients are discovering the many different ways they can change ... currently available to them and which ones might work for their smiles. , ...
(Date:4/29/2016)... ... , ... For those who skip meals occasionally (which is pretty much everyone), ... many new lifestyle diet tips offered by nutritionists Pam Bonney and Priya Lawrence of ... show. Bonny and Lawrence noted that because proper nutrition, including water, provides energy during ...
(Date:4/29/2016)... ... April 29, 2016 , ... Regenerative Medicine Solutions (RMS) scored 94.8124 ... survey, earning them second place for Tampa’s Best Places to Work. They were ranked ... is a great accomplishment for our team,” says RMS Human Resources Manager Irene Miller. ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... New Jersey , April 29, 2016 /PRNewswire/ ... Software Suite for Life Sciences, Product Development Capabilities ... Global Life Science Customer Base . ... solutions provider, today announced the acquisition of Skura ... a global leader in adaptive sales enablement technology ...
(Date:4/28/2016)... 28, 2016   Click here for supplemental ... (NYSE: DPLO), the nation,s largest independent specialty pharmacy, ... agreement to acquire Valley Campus Pharmacy, Inc., doing ... leading specialty pharmacy that provides individualized patient care, ... . In 2015, TNH generated approximately $400 million ...
(Date:4/28/2016)... April 28, 2016 ... George Phillips und Stephen Schmidt ... ArisGlobal®, ein führender Anbieter cloudbasierter ... heute bekannt, dass neue Führungskräfte zum Team ... sind, die vielfältige Erfahrungen mitbringen.  Dies wird ...
Breaking Medicine Technology: