Navigation Links
VARI findings could help diagnose and treat liver cancer
Date:6/8/2010

Grand Rapids, Mich. (June 8, 2010) In collaboration with the National Cancer Centre, Singapore, Van Andel Research Institute (VARI) researchers have identified an enzyme that could help diagnose and treat cholangiocarcinoma, a form of liver cancer that strikes up to 3,000 new patients each year in the United States.

Cholangiocarcinoma is the second most common type of cancer that affects the hepatobiliary system, which includes the liver, gall bladder, and bile ducts. The disease is most commonly diagnosed in patients in their 60's and 70's, and prognosis is generally poor with a 5-year survival rate of less than 5%. The only current curative treatment of the disease is surgery to remove all tumor tissue, but most patients' cancer is too advanced upon diagnosis to operate.

Southeast Asia is particularly affected by cholangiocarcinoma, but incidence of the disease is rising in the United States, United Kingdom, and Australia.

"An advance in the diagnosis and treatment of this disease could have a profound impact," said Professor Khee Chee Soo, Director of the National Cancer Centre, Singapore. "Cholangiocarcinoma is especially prevalent in Southeast Asia where, because of chronic infections by liver flukes and other factors, it kills thousands each year."

Cholangiocarcinoma and hepatocellularcarcinoma (HCC) are the two main forms of malignant liver cancer and require different treatments. Researchers found that the enzyme p38delta mitogen-activated protein kinase (MAPK13) is found in higher levels in cholangiocarcinomas than in HCC or normal tissue, and that it plays a role in the ability of tumor cells to move and invade normal tissue.

MAPK13 could be used as a complement to current biomarkers in diagnosing cholangiocarcinoma and distinguishing it from HCC, and it could serve as a drug target to help treat cholangiocarcinoma.

"Cholangiocarcinomas are notoriously challenging to diagnose and treat," said VARI Distinguished Scientific Investigator Bin Tean Teh, M.D., Ph.D., whose laboratory published its findings in the May 15 issue of the International Journal of Cancer. "Discoveries that lead to earlier detection and diagnosis will improve the long-term survival rate of patients."


'/>"/>

Contact: Joe Gavan
joe.gavan@vai.org
616-234-5390
Van Andel Research Institute
Source:Eurekalert

Related medicine news :

1. Findings suggest optimal dose
2. Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
3. Research findings underscore needed action to safeguard lungs of young cancer survivors
4. Cedars-Sinai Heart Institute physicians present findings at ACC scientific meeting
5. Research findings expected to ease treatment of low neutrophil counts in cancer patients
6. UMass Lowell researchers findings suggest new ways to diagnose and treat Alzheimers
7. VARI findings may help patients with deadly kidney cancer
8. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
9. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
10. New Report and Survey Findings Highlight Why More Women Die From Heart Disease Than Men
11. Gene Findings in Autism, Blindness at Childrens Hospital Top National Lists of Medical Advances in 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... ... Planet Fitness, one of the largest and fastest growing franchisors and operators ... location in Covington, LA at 401 N. U.S. Highway 190, in January of 2018. ... in the Holiday Square shopping center. Its location allows it to serve both Covington ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
(Date:9/19/2017)... Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company ... destruction of targeted tissues, announced three leadership team developments today:   ... PhD ... ... Veteran medical device executive Josh ...
(Date:9/13/2017)... 13, 2017   OrthoAtlanta has been named the ... Host Committee (AFHC) for the 2018 College Football Playoff (CFP) ... at Mercedes-Benz Stadium in Atlanta, Georgia . ... "I,m In" campaign, participating in many activities leading up to, ... ...
Breaking Medicine Technology: