Navigation Links
VARI findings could help diagnose and treat liver cancer

Grand Rapids, Mich. (June 8, 2010) In collaboration with the National Cancer Centre, Singapore, Van Andel Research Institute (VARI) researchers have identified an enzyme that could help diagnose and treat cholangiocarcinoma, a form of liver cancer that strikes up to 3,000 new patients each year in the United States.

Cholangiocarcinoma is the second most common type of cancer that affects the hepatobiliary system, which includes the liver, gall bladder, and bile ducts. The disease is most commonly diagnosed in patients in their 60's and 70's, and prognosis is generally poor with a 5-year survival rate of less than 5%. The only current curative treatment of the disease is surgery to remove all tumor tissue, but most patients' cancer is too advanced upon diagnosis to operate.

Southeast Asia is particularly affected by cholangiocarcinoma, but incidence of the disease is rising in the United States, United Kingdom, and Australia.

"An advance in the diagnosis and treatment of this disease could have a profound impact," said Professor Khee Chee Soo, Director of the National Cancer Centre, Singapore. "Cholangiocarcinoma is especially prevalent in Southeast Asia where, because of chronic infections by liver flukes and other factors, it kills thousands each year."

Cholangiocarcinoma and hepatocellularcarcinoma (HCC) are the two main forms of malignant liver cancer and require different treatments. Researchers found that the enzyme p38delta mitogen-activated protein kinase (MAPK13) is found in higher levels in cholangiocarcinomas than in HCC or normal tissue, and that it plays a role in the ability of tumor cells to move and invade normal tissue.

MAPK13 could be used as a complement to current biomarkers in diagnosing cholangiocarcinoma and distinguishing it from HCC, and it could serve as a drug target to help treat cholangiocarcinoma.

"Cholangiocarcinomas are notoriously challenging to diagnose and treat," said VARI Distinguished Scientific Investigator Bin Tean Teh, M.D., Ph.D., whose laboratory published its findings in the May 15 issue of the International Journal of Cancer. "Discoveries that lead to earlier detection and diagnosis will improve the long-term survival rate of patients."


Contact: Joe Gavan
Van Andel Research Institute

Related medicine news :

1. Findings suggest optimal dose
2. Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
3. Research findings underscore needed action to safeguard lungs of young cancer survivors
4. Cedars-Sinai Heart Institute physicians present findings at ACC scientific meeting
5. Research findings expected to ease treatment of low neutrophil counts in cancer patients
6. UMass Lowell researchers findings suggest new ways to diagnose and treat Alzheimers
7. VARI findings may help patients with deadly kidney cancer
8. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
9. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
10. New Report and Survey Findings Highlight Why More Women Die From Heart Disease Than Men
11. Gene Findings in Autism, Blindness at Childrens Hospital Top National Lists of Medical Advances in 2009
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... Privately owned Contract Development ... expansion of its current state of the art research, development and manufacturing facility ... increase its manufacturing capacity as well as to support its clients’ growing research ...
(Date:11/25/2015)... ... November 25, 2015 , ... Many people know of the common symptoms of ... and dry skin. But many people who find their cholesterol levels and weight are ... their thyroid, especially if they don’t have any of the other symptoms. , Thyroid ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch in ... involving adult stem cell therapies to patients with chronic degenerative medical conditions. Now, ... a Registered Trademark (RTM). , Organizations are required to hold a registered trademark ...
(Date:11/25/2015)... ... November 25, 2015 , ... Bunion Bootie ... an early celebration of the early holiday shopping season. Starting Wednesday November 25th, ... $33.95 ea). Black Friday promotional pricing is in addition to any automatic discounts ...
(Date:11/24/2015)... , ... November 24, 2015 , ... ... to offer their patients the many benefits of the revolutionary BIOLASE WaterLase iPlus ... cutting and scraping tools traditionally used by a dentist in Gettysburg, PA ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... N.Y. , Nov. 25, 2015  Henry Schein, ... and services to office-based dental, medical and animal health ... (GNYDM) Meeting the Henry Schein ConnectDental® Pavilion , ... broadest array of open solutions designed to help any ... Click here for a schedule of experts ...
(Date:11/25/2015)... SAN DIEGO , Nov. 25, 2015  Trovagene, ... molecular diagnostics, today announced that Chief Executive Officer Antonius ... at the 27 th Annual Piper Jaffray Healthcare ... Conference at the New York Palace Hotel in ... 2015 at 1:30 p.m. EST. Mr. Schuh will be ...
(Date:11/25/2015)... 2015 Endo International plc (NASDAQ: ENDP ) ... President and CEO, will discuss corporate updates at the 27 ... New York on Wednesday, December 2, 2015 at ... Investor Relations, and then the link to the event. Participants ... time to visit the site and download any streaming media ...
Breaking Medicine Technology: