Uterus Size May Predict Risk for Premature Twins... (bies born severely premature with an inc...)

Uterus Size May Predict Risk for Premature Twins After IVF

Date:7/10/2008

bies born severely premature with an increased number of fetal deaths -- seven fetal deaths in this group compared with one in the women with medium-size uteri (between 64 and 70 millimeters high) and none among those with uterus height greater than 70 millimeters. Six deaths in the small uteri group were linked to prematurity, while the one death in the mid-sized group was not.

After adjusting for any confounding factors such as age, parity, previous premature delivery, the researchers found a clear association with HSM.

"Our results show that HSM is a reliable and noninvasive method for predicting twin-related severe prematurity and neonatal mortality, and it can be used before conception to help with objective decision-making about the number of embryos to transfer," Hirt said. "For women with an HSM measurement of less than 62mm, a single-embryo transfer is indicated, but in those with a longer uterine cavity, a double-embryo transfer can be considered if it is acceptable to the patients."

The researchers plan to use their new criteria going forward and see whether it results in decreased fetal mortality. They also plan to study whether a short uterine cavity affects single pregnancies to find whether it can identify which women may need intensive neonatal care.

More information

The National Institute of Child Health and Human Development has more about fertility and infertility.

-- Kevin McKeever

SOURCE: European Society for Human Reproduction & Embryology, news release, July 8, 2008

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