Navigation Links
Ustekinumab Phase 3 data show long-term improvement of chronic plaque psoriasis
Date:2/2/2008

SAN ANTONIO, TX, February 2, 2008 One-year data from a second double-blind, placebo-controlled Phase 3 study showed therapy with ustekinumab given every 12 weeks provided sustained, clinically meaningful improvement in the treatment of moderate to severe plaque psoriasis through one year. According to findings presented at the Annual Meeting of the American Academy of Dermatology, 87 percent of patients responding to ustekinumab 45 mg maintenance therapy and 91 percent of patients responding to ustekinumab 90 mg maintenance therapy sustained at least a 75 percent improvement in psoriasis through one year, as measured by the Psoriasis Area and Severity Index (PASI 75). Ustekinumab is a new human monoclonal antibody with a novel mechanism of action that targets the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23), naturally occurring proteins that are important in the bodys regulation of immune responses and that are also believed to play a role in immune-mediated inflammatory disorders, including psoriasis.

In December 2007, Centocor announced that a Biologics License Application (BLA) had been submitted to the U.S. Food and Drug Administration (FDA) and Janssen-Cilag International NV announced its submission of a Marketing Authorization Application (MAA) to the European Medicines Agency (EMEA).

These findings show that ustekinumab may control plaque psoriasis with as few as four injections a year, says lead study investigator Kenneth Gordon, MD, associate professor, Feinberg School of Medicine, Northwestern University, and Head of Dermatology, Evanston Northwestern Healthcare, Skokie, IL. We are encouraged by the results seen in clinical trials to date and the hope that ustekinumab may hold for patients and the dermatology community.

The primary endpoint of the Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Trial Evaluating the Efficacy and Safety of CNTO 1275 in the Treatment of Subjects with Mode
'/>"/>

Contact: Brian Kenney
BKenney1@cntus.jnj.com
215-325-2107
Centocor, Inc.
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Medarex to Receive Milestone Payment for Submission of Regulatory Applications Requesting Approval of Ustekinumab (CNTO 1275) for Treatment of Psoriasis
2. Promising Phase 3 trial results show biologic therapy ustekinumab significantly improved psoriasis
3. Kiadis Pharma Announces Successful Completion of Rhitol(TM) Phase II Clinical Study
4. Medivation Plans to Initiate Pivotal Confirmatory Phase 3 Trial of Dimebon(TM) for Alzheimers Disease in Second Quarter of 2008
5. MDS Pharma Services Opens Largest Phase I Clinic on U.S. West Coast
6. Immunosyn Announces the Successful Completion of First Phase Proof of Concept Trial in Europe for Treatment of Diabetic Ulcers With Biopharmeceutical SF-1019
7. MAP Pharmaceuticals Reaches Agreement with FDA on Special Protocol Assessment for MAP0004 Phase 3 Clinical Trial in Patients With Migraine
8. Bisexuality not a transitional phase among women, according to new research
9. Cadence Pharmaceuticals Announces Topline Results of Two Phase III Clinical Trials of Acetavance(TM)
10. Kosan Opens TIME-1 Pivotal Phase 3 Trial in Multiple Myeloma
11. Ardea Biosciences Lead NNRTI for HIV, RDEA806, to Enter Phase 2a Proof-of- Concept Clinical Trial
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... August 29, 2014 First Choice Emergency ... at 7am today. The new facility is located 1501 FM ... team is pleased to be a part of First Choice ... to continuing to deliver high quality emergency medical care to ... of First Choice Emergency Room Pflugerville – FM 685. ...
(Date:8/29/2014)... Tim Moffitt, who is representing Buncombe ... Assembly, spent the morning of Tuesday, August 26th with ... , Representative Moffitt’s visit was intended to get an ... company and to discuss how the ever changing landscape ... Aeroflow. , Josh Hill, Director of Business Development ...
(Date:8/29/2014)... Top10BestSEOHosting.com today compares many professional Windows web ... Bluehost ( http://www.bluehost.com/track/seohosts ), Arvixe, and Hostgator are ... who want to buy high quality WordPress hosting ... rates. , Bluehost is also a popular hosting ... is that Bluehost provides quality hosting and great ...
(Date:8/29/2014)... 29, 2014 The Department of ... Administration (FDA), Center for Food Safety and Applied ... indefinite quantity (IDIQ) contract and the first two ... “Development, Modernization and Enhancement (DME) for FARM VI” ... , Overarching contract objectives include:, , ...
(Date:8/29/2014)... Two Kelowna dentists are putting out ... a container filled with classroom materials, clinic supplies and even ... , “I don’t think words can describe ... Matson-Visscher. She and her husband, Dr. Jonathan Visscher, both partners ... part of New Reality International’s (NRI) mission to build and ...
Breaking Medicine News(10 mins):Health News:First Choice Emergency Room Opens New Facility in Pflugerville, Texas 2Health News:North Carolina Representative Tim Moffitt Visits Aeroflow Healthcare 2Health News:Top10BestSEOHosting.com: Bluehost, Arvixe, and Hostgator Are the Best Windows Web Hosting from the USA in 2014 2Health News:Team VersaTech and CRGT Win HHS FDA Contract to Support Food Applications Regulatory Management (FARM) System Upgrade 2Health News:Team VersaTech and CRGT Win HHS FDA Contract to Support Food Applications Regulatory Management (FARM) System Upgrade 3Health News:From Canada to Haiti: Kelowna Dentists Raise Funds to Ship Supplies to Self-Sustaining Village for Orphans 2Health News:From Canada to Haiti: Kelowna Dentists Raise Funds to Ship Supplies to Self-Sustaining Village for Orphans 3
... Vision Center at Childrens Hospital Los Angeles announced that more ... program that began earlier this year. The gift cards have ... problems and are treated at The Vision Center ... ARCO gas stations. Some families have been provided Metro tokens."The ...
... May 7 /PRNewswire/ -- John Fraser, ... thankful for the Hershey kisses that he and his United ... the "Battle of the Bulge."In a recent letter to the ... wrote:"I flew 35 missions over enemy territory. I got ...
... May 7 Integral Consulting Inc., a national ... in health, environment, technology, and sustainability, today announced ... include principal level and senior level scientists who ... Lucinda Jacobs, Integral President and Principal Sediment Scientist, ...
... all gestures, researchers say, , , THURSDAY, May 7 (HealthDay News) ... kids, at least when it comes to figuring out where ... team of Hungarian researchers, who also found that 3-year-olds surpass ... , At age 3, kids can locate a hidden toy ...
... activity in certain areas, researchers say , , THURSDAY, May ... brain stimulation improved symptoms and, in some cases, launched ... had suffered for decades and who had failed multiple ... had had depression for 27 years and had failed ...
... emphasizes conservation during public campaignSACRAMENTO, Calif., May 7 ... has been declared "Drinking Water Week" by the ... California American Water is raising awareness amongst its ... need for safe and reliable drinking water supplies ...
Cached Medicine News:Health News:200 Families of Children With Serious Eye Problems Benefit From Unique Gift Card Program at The Vision Center at Childrens Hospital Los Angeles 2Health News:World War II Air Force Veteran Remembers 'Kisses' Sweeter Than Wine 2Health News:Science and Engineering Firm Integral Consulting Inc. Announces Employee Promotions 2Health News:Pooches Sometimes Miss the Point 2Health News:Pooches Sometimes Miss the Point 3Health News:Brain Stimulation Therapy Eases Tough-to-Treat Depression 2Health News:Brain Stimulation Therapy Eases Tough-to-Treat Depression 3Health News:Brain Stimulation Therapy Eases Tough-to-Treat Depression 4Health News:May 3rd - 9th is 'Drinking Water Week' 2
(Date:8/28/2014)... Aug. 28, 2014   Venaxis, Inc.  (Nasdaq:  APPY), ... obtaining FDA clearance for and commercializing its CE Marked ... aiding in identifying children, adolescent, and young adult patients ... for appendicitis, today announced it will present at three ... Annual Global Investment Conference being held in ...
(Date:8/28/2014)... Aug. 28, 2014 Reportlinker.com ... report is available in its catalogue: ... - Broadened Diagnostic Criteria and Growing ... despite Patent Expirations ... Therapeutics to 2020 - Broadened Diagnostic ...
(Date:8/28/2014)... --  RapidForce , an innovative muscle support and pain ... professional tennis player John Isner . Currently the ... competitions to help with knee support. He is wearing ... US Open Tennis Championships. Fifteen times ... a revolutionary hybrid of a brace and kinesiology tape. ...
Breaking Medicine Technology:Venaxis to Present at September Investor Conferences 2Venaxis to Present at September Investor Conferences 3ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 2ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 3ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 4ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 5ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 6ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 7ADHD Therapeutics to 2020 - Broadened Diagnostic Criteria and Growing Adult Prevalence to Drive Market Growth despite Patent Expirations 8America's top-ranked tennis player John Isner Joins Forces with RAPIDFORCE Physio Hybrid Shapes 2America's top-ranked tennis player John Isner Joins Forces with RAPIDFORCE Physio Hybrid Shapes 3America's top-ranked tennis player John Isner Joins Forces with RAPIDFORCE Physio Hybrid Shapes 4
... Aug. 17 In response to unprecedented devastation and human ... Foundations today announced it would give an additional $5 million ... "We need everyone to pitch in to the ... Open Society Foundation in Pakistan – FOSI-Pakistan. "While the government ...
... FEICHENG, China, Aug. 17 /PRNewswire-Asia-FirstCall/ -- ... ... var shortURL ... by longUrl, so we need to grab the first one. for (var r in data.results) { ...
Cached Medicine Technology:George Soros to Boost Civil Society Response in Flood Affected Areas of Pakistan 2China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 2China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 3China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 4China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 5China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 6China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 7China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 8China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 9China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 10China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 11China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 12China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 13China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 14China Ruitai International Holdings Co., Ltd. Reports Financial Results for the Second Quarter 2010 15
Unique criss-cross strapping distributes weight evenly over the torso for ultimate comfort and flexibility. Fully adjustable 2 inch belt and buckle for easy front closure....
Six inch wide elastic belt transfers the apron weight off the shoulders. 0.5mm front and 0.25mm back with a generous overlap for double protection. Shoulder pads included. Also available without wide...
Our 'flex' removes the apron weight from the shoulders while providing back support. Unlike other elastic backs, ours does not wrinkle up, making cleaning easier....
Economically priced - same high quality as our Standard, with 1" ties. Adjustable back ties keep apron snug....
Medicine Products: