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Using new approach, Mayo Clinic researchers find level of gene alters risk of Alzheimer's disease
Date:3/15/2010

JACKSONVILLE, Fla. Using sophisticated techniques that scan the genomes of patients, researchers at the Mayo Clinic campus in Florida have found that a gene appears to either help protect against development of Alzheimer's disease, or promote the disorder depending on the level of gene in the brain.

In two research studies published almost simultaneously in the journals Neurology and PLoS ONE, the scientists found strong evidence for the role of the gene, insulin-degrading enzyme (IDE), in influencing risk of Alzheimer's disease. The Mayo researchers were one of the groups that first found an association between IDE and Alzheimer's several years ago, but these new findings now offer a novel theory about how the gene could be involved in the disease process.

"We found a new mechanism of action for this Alzheimer's disease susceptibility gene, that acts by altering gene expression levels," says neuroscientist and neurologist Nilufer Ertekin-Taner, M.D., Ph.D., the lead investigator on the Neurology study and contributor to the PLoS ONE research.

Fanggeng Zou, Ph.D., and Minerva Carrasquillo, Ph.D., are the joint first authors of the Neurology study. Drs. Carrasquillo and Zou, Olivia Belbin, Ph.D., and Ph.D. candidate Mariet Allen are the joint first authors of the PLoS ONE study. Both studies were published online in early 2010.

IDE is known to break apart amyloid beta, the protein that clumps together in the brains of Alzheimer's patients. The Mayo researchers say their findings suggest that too little expression of IDE may promote development of the disease, while increased expression appears to protect against the disorder.

"It is an issue of the level of the normal gene, not whether a gene is in a mutant form that is not acting properly," says Dr. Ertekin-Taner. "We believe this is a novel and potentially powerful approach to understanding the complex biology behind deve
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Contact: Cynthia Nelson
nelson.cynthia1@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

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