Navigation Links
Using microbubbles to improve cancer therapy

Microbubbles decrease the time and acoustic power of ultrasound required to heat and destroy an embedded target, finds research in BioMed Central's open access journal Journal of Therapeutic Ultrasound. If these results can be replicated in the clinic, microbubbles could improve the efficiency of high intensity ultrasound treatment of solid tumors.

High intensity ultrasound is already used to treat solid tumors. Ultrasound can be focused through soft tissue and, because it does not require probes or surgery, is non-invasive. However if the tumor is behind the ribcage or skull, the bone absorbs some of the ultrasound. Consequently the length of treatment needs to be increased, plus there is a potential for heat damage to the bone.

In order to improve ultrasound therapy, especially in these difficult to treat cases, a team from Boston University has developed phase shift nanoemulsions (PSNE), which produce tiny microbubbles when blasted with high intensity ultrasound. Microbubbles smaller than 200nm passively accumulate in tumors and this study shows that microbubbles of this size can amplify the effects of ultrasound in hydrogels designed to mimic solid tumors inside the body.

Holes formed in a predictable manner and with a predictable shape which altered with acoustic intensity. The acoustic intensity and exposure time required for thermal destruction of tumor tissue were both reduced by more than half, compared to ultrasound without microbubbles. The lower power levels and time needed to destroy a target in the presence of microbubbles could potentially improve cancer therapy, especially in hard to reach areas.

The first stage in any new treatment is to show safety and efficacy. Prof Tyrone Porter, who led this study explained, "We used PSNE of phospholipid coated perfluorcarbon which have no known toxicity and have already be shown to be safe clinically. Our technique pushes forward the possible applications of ultrasound therapy in treating solid tumors."

Open access publisher BioMed Central is proud to announce the launch of Journal of Therapeutic Ultrasound in partnership with the Focused Ultrasound Foundation and the International Society for Therapeutic Ultrasound.

"Focused ultrasound technology has enormous potential to improve the quality of lives for millions around the world," noted Neal F. Kassell, M.D., Chairman and Founder of the Focused Ultrasound Foundation. "The research reported in the Journal of Therapeutic Ultrasound will be central to advancing the field and will help accelerate the progress of focused ultrasound towards clinical adoption."


Contact: Hilary Glover
BioMed Central

Related medicine news :

1. MU receives national award for using mind-body approach to improve health
2. More Teen Girls Using Contraceptives: CDC
3. Using Earplugs Eases ICU Patients Confusion: Study
4. 16 years old is peak risk for teens misusing prescription drugs
5. Kids Most Likely to Start Abusing Painkillers at 16: Study
6. Breathing during radiotherapy - how to hit the treatment target without causing collateral damage
7. Report using private health claims data shows prices are driving health spending growth
8. Type of viral infection of eye associated with disease causing blindness in the elderly
9. Hepatitis C Causing Liver Damage in Greater Numbers: Study
10. Pivotal role for proteins -- from helping turn carbs into energy to causing devastating disease
11. Population displacement during disasters predicted using mobile data
Post Your Comments:
(Date:6/27/2016)... ... , ... recently awarded their highest five-star rating to Best Buy Eyeglasses, ... the United States and Canada wear eyeglasses. Once considered to be a purely functional ... a fashion statement. Even celebrities use glasses as a way of creating an iconic ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, ... editors can give their videos a whole new perspective by using the title ... Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to choose ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
Breaking Medicine Technology: