Navigation Links
Using insects to test for drug safety
Date:9/7/2009

Insects, such as some moths and fruit flies, react to microbial infection in the same way as mammals and so can be used to test the efficiency of new drugs, thereby reducing the need for animal testing. Dr Kevin Kavanagh from the National University of Ireland Maynooth, presented his research findings at the Society for General Microbiology's meeting at Heriot Watt University, Edinburgh, today (8 September).

Neutrophils, which are a type of white blood cell and part of the mammalian immune system, and haematocytes, which are cells that carry out a similar function in insects, react in the same way to infecting microbes. Both the insect and mammalian cells produce chemicals with a similar structure which move to the surface of the cells to kill the invading microbe. The immune cells then enclose the microbe and release enzymes to break it down.

Insects such as fruit flies (Drosophila), Greater Wax Moths (Galleria) and a type of Hawkmoth (Manduca) can be used to test the efficacy of new antimicrobial drugs or to judge how virulent fungal pathogens are. It is now routine practice to use insect larvae to perform initial testing of new drugs and then to use mice for confirmation tests. As well as reducing by up to 90% the number of mice required, this method of testing is quicker as tests with insects yield results in 48󈞴 hours whereas tests with mice usually take 4-6 weeks.

""We will continue to explore the similarities between insect and mammalian immune responses so that insects can be used as models to study different disease states in humans," said Dr Kavanagh.

"In addition we have shown that immune cells in insects and mammals are structurally and functionally similar despite being separated by over 400 million years of evolution."


'/>"/>

Contact: Dianne Stilwell
diannestilwell@me.com
07-957-200-214
Society for General Microbiology
Source:Eurekalert

Page: 1

Related medicine news :

1. Using coxibs and NSAIDs to treat osteoarthritis
2. Adverse housing conditions contribute to diabetes risk
3. Females avoid incest by causing male relatives to leave home
4. Are Bargaining Groups Hired by Independent Drugstores Causing Payment Delays to Pharmacies?
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. National Council of Negro Women (NCNW) Partners With Sherwin-Williams to Target Lead Risks in Neglected Housing
7. Using the Internet to Promote Exercise
8. Hazards of using crib bumper pads outweigh their benefits
9. Nosespray vaccine using aloe vera has exciting potential, researcher says
10. Patient Safety Authority Releases Advisory Focusing on Common Causes of Medication Errors
11. Genetic test announced for suicidal ideation in patients using antidepressant drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... Tx (PRWEB) , ... April 24, 2017 , ... ... Lief Therapeutics designed to recognize elevated anxiety levels in people with addiction who ... the Lief Smart Patch, a biosensing wearable device that monitors heart and breath ...
(Date:4/24/2017)... ... April 24, 2017 , ... Come to PAINWeekEnd (PWE) Tampa on ... Blvd, for an educational and exciting 2-day program. , An attendee at a ... before they approach patients” about the course entitled Ain't Misbehavin': Decreasing and Managing Pain ...
(Date:4/24/2017)... ... ... “Reflections of God’s Work”: an enlightening collection of life lessons leading each ... published author, Jerri Broglin, a survivor of great loss who gained insight on how ... for those searching for answers, as we are finding the answers that are so ...
(Date:4/24/2017)... Gainesville, Florida (PRWEB) , ... April 24, 2017 , ... ... at the University of Florida. The event will be held at 7:30 pm on ... and Ken Block and Drew Copeland of Sister Hazel, will support the UF Collegiate ...
(Date:4/23/2017)... ... 23, 2017 , ... "An event Horizon is a place where the laws ... Art and Music. These are created as Metaphysical Transformations where music, which is the ... to the ultimate singularity.", -- Karen Salicath Jamali , Karen will also preview her ...
Breaking Medicine News(10 mins):
(Date:4/21/2017)... , April 21, 2017 Halo Labs ... throughput biopharmaceutical particle analysis system called the Horizon at ... May 1st. The new system analyzes sub visible particulate ... time rapid particle screening as early as candidate selection ... with leading biopharma contract research organization Elion Labs ...
(Date:4/20/2017)... , April 20, 2017  RXi Pharmaceuticals Corporation ... therapeutics that address significant unmet medical needs, today ... the Company,s consumer product development program, based on ... Society for Investigative Dermatology (SID) 76 th ... and promote the sciences relevant to skin health ...
(Date:4/20/2017)... , April 20, 2017 Research and ... Market Size, Market Share, Application Analysis, Regional Outlook, Growth Trends, ... report to their offering. ... The global pharmacogenomics market was valued at US$ 7,167.6 Mn ... by 2024, expanding at a CAGR of 5.6% from 2016 ...
Breaking Medicine Technology: