Navigation Links
Using insects to test for drug safety
Date:9/7/2009

Insects, such as some moths and fruit flies, react to microbial infection in the same way as mammals and so can be used to test the efficiency of new drugs, thereby reducing the need for animal testing. Dr Kevin Kavanagh from the National University of Ireland Maynooth, presented his research findings at the Society for General Microbiology's meeting at Heriot Watt University, Edinburgh, today (8 September).

Neutrophils, which are a type of white blood cell and part of the mammalian immune system, and haematocytes, which are cells that carry out a similar function in insects, react in the same way to infecting microbes. Both the insect and mammalian cells produce chemicals with a similar structure which move to the surface of the cells to kill the invading microbe. The immune cells then enclose the microbe and release enzymes to break it down.

Insects such as fruit flies (Drosophila), Greater Wax Moths (Galleria) and a type of Hawkmoth (Manduca) can be used to test the efficacy of new antimicrobial drugs or to judge how virulent fungal pathogens are. It is now routine practice to use insect larvae to perform initial testing of new drugs and then to use mice for confirmation tests. As well as reducing by up to 90% the number of mice required, this method of testing is quicker as tests with insects yield results in 48󈞴 hours whereas tests with mice usually take 4-6 weeks.

""We will continue to explore the similarities between insect and mammalian immune responses so that insects can be used as models to study different disease states in humans," said Dr Kavanagh.

"In addition we have shown that immune cells in insects and mammals are structurally and functionally similar despite being separated by over 400 million years of evolution."


'/>"/>

Contact: Dianne Stilwell
diannestilwell@me.com
07-957-200-214
Society for General Microbiology
Source:Eurekalert

Page: 1

Related medicine news :

1. Using coxibs and NSAIDs to treat osteoarthritis
2. Adverse housing conditions contribute to diabetes risk
3. Females avoid incest by causing male relatives to leave home
4. Are Bargaining Groups Hired by Independent Drugstores Causing Payment Delays to Pharmacies?
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. National Council of Negro Women (NCNW) Partners With Sherwin-Williams to Target Lead Risks in Neglected Housing
7. Using the Internet to Promote Exercise
8. Hazards of using crib bumper pads outweigh their benefits
9. Nosespray vaccine using aloe vera has exciting potential, researcher says
10. Patient Safety Authority Releases Advisory Focusing on Common Causes of Medication Errors
11. Genetic test announced for suicidal ideation in patients using antidepressant drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 27, 2016 , ... TherapySites, the leading website ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to ... adding exclusive benefits and promotional offers. , "TCA is extremely excited about this ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Pixel Film Studios ... X. , "Film editors can give their videos a whole new perspective by using ... - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different ...
(Date:6/26/2016)... ... ... a legally blind and certified personal trainer is helping to develop a weight loss fitness ... to fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... 2016   Bay Area Lyme Foundation , ... Center for Tick Borne Illness , Harvard Medical ... Hacking Medicine, University of California, Berkeley, and the ... five finalists of Lyme Innovation , the ... 100 scientists, clinicians, researchers, entrepreneurs, and investors from ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
Breaking Medicine Technology: