Navigation Links
Using insects to test for drug safety
Date:9/7/2009

Insects, such as some moths and fruit flies, react to microbial infection in the same way as mammals and so can be used to test the efficiency of new drugs, thereby reducing the need for animal testing. Dr Kevin Kavanagh from the National University of Ireland Maynooth, presented his research findings at the Society for General Microbiology's meeting at Heriot Watt University, Edinburgh, today (8 September).

Neutrophils, which are a type of white blood cell and part of the mammalian immune system, and haematocytes, which are cells that carry out a similar function in insects, react in the same way to infecting microbes. Both the insect and mammalian cells produce chemicals with a similar structure which move to the surface of the cells to kill the invading microbe. The immune cells then enclose the microbe and release enzymes to break it down.

Insects such as fruit flies (Drosophila), Greater Wax Moths (Galleria) and a type of Hawkmoth (Manduca) can be used to test the efficacy of new antimicrobial drugs or to judge how virulent fungal pathogens are. It is now routine practice to use insect larvae to perform initial testing of new drugs and then to use mice for confirmation tests. As well as reducing by up to 90% the number of mice required, this method of testing is quicker as tests with insects yield results in 48󈞴 hours whereas tests with mice usually take 4-6 weeks.

""We will continue to explore the similarities between insect and mammalian immune responses so that insects can be used as models to study different disease states in humans," said Dr Kavanagh.

"In addition we have shown that immune cells in insects and mammals are structurally and functionally similar despite being separated by over 400 million years of evolution."


'/>"/>

Contact: Dianne Stilwell
diannestilwell@me.com
07-957-200-214
Society for General Microbiology
Source:Eurekalert

Page: 1

Related medicine news :

1. Using coxibs and NSAIDs to treat osteoarthritis
2. Adverse housing conditions contribute to diabetes risk
3. Females avoid incest by causing male relatives to leave home
4. Are Bargaining Groups Hired by Independent Drugstores Causing Payment Delays to Pharmacies?
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. National Council of Negro Women (NCNW) Partners With Sherwin-Williams to Target Lead Risks in Neglected Housing
7. Using the Internet to Promote Exercise
8. Hazards of using crib bumper pads outweigh their benefits
9. Nosespray vaccine using aloe vera has exciting potential, researcher says
10. Patient Safety Authority Releases Advisory Focusing on Common Causes of Medication Errors
11. Genetic test announced for suicidal ideation in patients using antidepressant drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... Maryland (PRWEB) , ... March 24, 2017 , ... ... is the first Certified Medical Reiki™ Master in Frederick, MD. Judy says, “I ... their caregivers during what is often a very difficult and challenging time.” , ...
(Date:3/24/2017)... ... ... “End Time GPS”: a dauntless and enlightened study of the second-coming of Christ, ... of published author, Wesley Gerboth, a World War II veteran, with a highly-regarded reputation ... age ninety-one, he shares the Wisdom God bestowed upon him in this publication. ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The ... about real people of God in congregations across the United States. “The ... minister ordained in 1964 who has served congregations in seven states throughout his ...
(Date:3/23/2017)... ... March 23, 2017 , ... In 2016 the World Health ... there could be four million Zika-related cases in the Americas within the next year. ... US cases reported per year skyrocketing to an estimated 329,000. Yet, Zika, Lyme and ...
(Date:3/23/2017)... ... ... The physicians of KSF Orthopaedic Center PA are proud to announce the opening ... at 2255 E. Mossy Oaks Rd., Suite 440, Spring, Texas 77389 inside the new ... in the north Houston area (The Woodlands, Conroe, Magnolia, Kingwood, Humble) with an even ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... -- GenomeDx Biosciences today announced that six abstracts featuring Decipher ... Classifier tests will be presented at the 32 nd ... March 24 to 28, 2017 in London, ... Europe,s largest urological event showcasing the ... The abstract titled "Muscle invasive bladder cancer: ...
(Date:3/24/2017)... GENEVA , March 24, 2017 ... efforts to develop sutezolid as effective response to infectious ... TB Alliance and the Medicines Patent Pool (MPP) announced ... an antibiotic drug candidate which demonstrated encouraging results in ... sutezolid in combination with other TB drugs and follows ...
(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Procedure By Technique, Repair Procedure By Technique, By Region, By Country ... ... to grow at a CAGR of 13.35% during 2016-2021 ... aging population, growth in population with heart disease and rising advances ...
Breaking Medicine Technology: