Navigation Links
Using insects to test for drug safety
Date:9/7/2009

Insects, such as some moths and fruit flies, react to microbial infection in the same way as mammals and so can be used to test the efficiency of new drugs, thereby reducing the need for animal testing. Dr Kevin Kavanagh from the National University of Ireland Maynooth, presented his research findings at the Society for General Microbiology's meeting at Heriot Watt University, Edinburgh, today (8 September).

Neutrophils, which are a type of white blood cell and part of the mammalian immune system, and haematocytes, which are cells that carry out a similar function in insects, react in the same way to infecting microbes. Both the insect and mammalian cells produce chemicals with a similar structure which move to the surface of the cells to kill the invading microbe. The immune cells then enclose the microbe and release enzymes to break it down.

Insects such as fruit flies (Drosophila), Greater Wax Moths (Galleria) and a type of Hawkmoth (Manduca) can be used to test the efficacy of new antimicrobial drugs or to judge how virulent fungal pathogens are. It is now routine practice to use insect larvae to perform initial testing of new drugs and then to use mice for confirmation tests. As well as reducing by up to 90% the number of mice required, this method of testing is quicker as tests with insects yield results in 48󈞴 hours whereas tests with mice usually take 4-6 weeks.

""We will continue to explore the similarities between insect and mammalian immune responses so that insects can be used as models to study different disease states in humans," said Dr Kavanagh.

"In addition we have shown that immune cells in insects and mammals are structurally and functionally similar despite being separated by over 400 million years of evolution."


'/>"/>

Contact: Dianne Stilwell
diannestilwell@me.com
07-957-200-214
Society for General Microbiology
Source:Eurekalert

Page: 1

Related medicine news :

1. Using coxibs and NSAIDs to treat osteoarthritis
2. Adverse housing conditions contribute to diabetes risk
3. Females avoid incest by causing male relatives to leave home
4. Are Bargaining Groups Hired by Independent Drugstores Causing Payment Delays to Pharmacies?
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. National Council of Negro Women (NCNW) Partners With Sherwin-Williams to Target Lead Risks in Neglected Housing
7. Using the Internet to Promote Exercise
8. Hazards of using crib bumper pads outweigh their benefits
9. Nosespray vaccine using aloe vera has exciting potential, researcher says
10. Patient Safety Authority Releases Advisory Focusing on Common Causes of Medication Errors
11. Genetic test announced for suicidal ideation in patients using antidepressant drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... The Military Officers Association ... for deputy secretary of Veterans Affairs, retired Marine Col. Thomas G. Bowman. , Bowman ... , Bowman brings an intimacy with the issues and challenges veterans face with ...
(Date:6/23/2017)... ... June 23, 2017 , ... Everybody has their own personal preference when it ... it, and some people don't like it at all. FindaTopDoc took a look at ... Erotic literature can give readers a taste of their deepest, darkest fantasies and has ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ensuring meat products have ... highlight the importance of correctly using a meat thermometer. The videos feature University ... research on consumer food safety habits. Dr. Bruhn explains the variety of meat ...
(Date:6/23/2017)... Palm Beach, FL (PRWEB) , ... June 23, 2017 , ... ... 19, in Pinecrest, Florida. This is MD Now’s 28th facility overall and marks the ... S. Dixie Highway, located one mile North of The Falls shopping mall. The new ...
(Date:6/23/2017)... ... June 23, 2017 , ... American Farmer, will feature Chr. Hansen, ... slated to air fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET on RFD-TV. ... pharmacist, founded Chr. Hansen in Denmark in 1874 after a groundbreaking discovery of how ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)...  Diplomat Specialty Infusion Group, a brand of Diplomat Pharmacy, Inc. ... Iowa location. The Iowa ... an ISO 7 cleanroom—the standard needed to compound intravenous (IV) nutrition ... of pollutants. "Our new cleanroom ... serve our Iowa patients," said Phil ...
(Date:6/1/2017)... 2017 Nutriceutical Holdings (NH), parent company of ... and KD Pharma Group have decided to join forces ... Pharma Group. KD Pharma Group will become the largest ... the entire company. "We believe we have ... to growing the NH companies by providing us with ...
(Date:5/26/2017)... 2017  Endo International plc (NASDAQ: ENDP ) ... will represent the Company in a fireside chat at Goldman ... June 13, 2017 at 10:40 a.m. PT / 1:40 p.m. ... Rancho Palos Verdes, CA. ... be available on the Company,s website at http://www.endo.com/investors/overview . ...
Breaking Medicine Technology: