Navigation Links
Using gold nanoparticles to hit cancer where it hurts
Date:2/16/2010

Taking gold nanoparticles to the cancer cell and hitting them with a laser has been shown to be a promising tool in fighting cancer, but what about cancers that occur in places where a laser light can't reach? Scientists at the Georgia Institute of Technology have shown that by directing gold nanoparticles into the nuclei of cancer cells, they can not only prevent them from multiplying, but can kill them where they lurk. The research appeared as a communication in the February 10 edition of the Journal of the American Chemical Society.

"We've developed a system that can kill cancer cells by shining light on gold nanoparticles, but what if the cancer is in a place where we can't shine light on it? To fix that problem, we've decorated the gold with a chemical that brings it inside the nucleus of the cancer cell and stops it from dividing," said Mostafa El-Sayed, Regents professor and director of the Laser Dynamics Laboratory at Georgia Tech.

Once the cell stops dividing, apoptosis sets in and kills the cell.

"In cancer, the nucleus divides much faster than that of a normal cell, so if we can stop it from dividing, we can stop the cancer," said El-Sayed.

The team tested their hypothesis on cells harvested from cancer of the ear, nose and throat. They decorated the cells with an argininge-glycine-aspartic acide petipde (RGD) to bring the gold nano-particles into the cytoplasm of a cancer cell but not the healthy cells and a nuclear localization signal peptide (NLS) to bring it into the nucleus.

In previous work they showed that just bringing the gold into the cytoplasm does nothing. In this current study, they found that implanting the gold into the nucleus effectively kills the cell.

"The cell starts dividing and then it collapses," said El-Sayed. "Once you have a cell with two nuclei, it dies." The gold works by interfering with the cells' DNA, he added. How that works exactly is the subject of a follow-up study.

"Previously, we've shown that we can bring gold nanoparticles into cancer cells and by shining a light on them, can kill the cells. Now we've shown that if we direct those gold nanoparticles into the nucleus, we can kill the cancer cells that are in spots we can't hit with the light," said El-Sayed.

Next the team will test how the treatment works in vivo.


'/>"/>

Contact: David Terraso
david.terraso@comm.gatech.edu
404-385-2966
Georgia Institute of Technology
Source:Eurekalert

Related medicine news :

1. Ecumen Building Senior Housing in Apple Valley, Minnesota and Will Manage New Maplewood, Minnesota Property
2. Using Nicotine Patch Longer Boosts Efforts to Quit
3. Study: Many physicians not using established criteria
4. Edgewood Partners Insurance Center Enhances Customer Support And Streamlines Processes Using Sofrront CRM
5. U.S. Kids Using Media Almost 8 Hours a Day
6. Innovative Orthopedic Nailing System Receives CE Mark using Oxford Performance Material's OXPEKK BioFlex™
7. APS Healthcare Issues First Award to South Carolina Providers Using Data to Increase Effectiveness of Mental Health Treatment
8. Promising New Results On The Added Safety Of Using SmokeStik Electronic Cigarettes In The Bid To Quit Smoking
9. Periodic Paralysis Study Reveals Gene Causing Disorder
10. ACS Webinar features tips for using a chemistry degree in finding career opportunities
11. Young hunters most likely to be injured using tree stands, say UAB researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... , ... May 27, 2016 , ... W.S. Badger ... announced today that it has been recognized as one of the best small businesses ... was named as one of nine small businesses providing progressive benefits to new parents ...
(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... ... with Mediaplanet to help educate the many who are unaware of the plight ... to aphasia will run within the “Stroke Awareness” campaign. , The link between ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... in the pharmaceutical, medical and food industries. Aside from its GMP accreditation, Validation ... providing proof of successfully certified products, services and staff. , Validation Center is ...
(Date:5/26/2016)... ... May 26, 2016 , ... Intalere, ... members and suppliers for its inaugural Member Conference at the Paris Hotel in ... elevating the operational health of America’s healthcare providers. , The conference was highlighted ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cardiac arrhythmia ... negative impact on long-term patient survival, reports a team of UPMC researchers in ... week in the Journal of Thoracic and Cardiovascular Surgery, provide critical information that ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... May 25, 2016 According to ... Type (3D, 2D, 4D), by Therapeutic Area (Oncology, Cosmeceutical/Plastic ... User (Medical Device Manufacturers, Hospitals/ Clinics) - Forecast to ... Medical Animation Market for the forecast period of 2016 ... 301.3 Million by 2021 from USD 117.3 Million in ...
(Date:5/25/2016)... 25, 2016 According to market ... Growth and Demand Forecast to 2022 - Industry Insights ... Others)" published by P&S Market Research, the global insulin ... 2015, and it is expected to grow at a ... insulin pump segment is expected to witness the fastest ...
(Date:5/25/2016)... England , May 25, 2016 ... company employing the precision of circulating tumour DNA ... today announces the appointment of Professor Clive ... provide medical leadership across the clinical development programme, ... Inivata,s products help deliver significant improvements in clinical ...
Breaking Medicine Technology: