Navigation Links
Using gold nanoparticles to hit cancer where it hurts
Date:2/16/2010

Taking gold nanoparticles to the cancer cell and hitting them with a laser has been shown to be a promising tool in fighting cancer, but what about cancers that occur in places where a laser light can't reach? Scientists at the Georgia Institute of Technology have shown that by directing gold nanoparticles into the nuclei of cancer cells, they can not only prevent them from multiplying, but can kill them where they lurk. The research appeared as a communication in the February 10 edition of the Journal of the American Chemical Society.

"We've developed a system that can kill cancer cells by shining light on gold nanoparticles, but what if the cancer is in a place where we can't shine light on it? To fix that problem, we've decorated the gold with a chemical that brings it inside the nucleus of the cancer cell and stops it from dividing," said Mostafa El-Sayed, Regents professor and director of the Laser Dynamics Laboratory at Georgia Tech.

Once the cell stops dividing, apoptosis sets in and kills the cell.

"In cancer, the nucleus divides much faster than that of a normal cell, so if we can stop it from dividing, we can stop the cancer," said El-Sayed.

The team tested their hypothesis on cells harvested from cancer of the ear, nose and throat. They decorated the cells with an argininge-glycine-aspartic acide petipde (RGD) to bring the gold nano-particles into the cytoplasm of a cancer cell but not the healthy cells and a nuclear localization signal peptide (NLS) to bring it into the nucleus.

In previous work they showed that just bringing the gold into the cytoplasm does nothing. In this current study, they found that implanting the gold into the nucleus effectively kills the cell.

"The cell starts dividing and then it collapses," said El-Sayed. "Once you have a cell with two nuclei, it dies." The gold works by interfering with the cells' DNA, he added. How that works exactly is the subject of a follow-up study.

"Previously, we've shown that we can bring gold nanoparticles into cancer cells and by shining a light on them, can kill the cells. Now we've shown that if we direct those gold nanoparticles into the nucleus, we can kill the cancer cells that are in spots we can't hit with the light," said El-Sayed.

Next the team will test how the treatment works in vivo.


'/>"/>

Contact: David Terraso
david.terraso@comm.gatech.edu
404-385-2966
Georgia Institute of Technology
Source:Eurekalert

Related medicine news :

1. Ecumen Building Senior Housing in Apple Valley, Minnesota and Will Manage New Maplewood, Minnesota Property
2. Using Nicotine Patch Longer Boosts Efforts to Quit
3. Study: Many physicians not using established criteria
4. Edgewood Partners Insurance Center Enhances Customer Support And Streamlines Processes Using Sofrront CRM
5. U.S. Kids Using Media Almost 8 Hours a Day
6. Innovative Orthopedic Nailing System Receives CE Mark using Oxford Performance Material's OXPEKK BioFlex™
7. APS Healthcare Issues First Award to South Carolina Providers Using Data to Increase Effectiveness of Mental Health Treatment
8. Promising New Results On The Added Safety Of Using SmokeStik Electronic Cigarettes In The Bid To Quit Smoking
9. Periodic Paralysis Study Reveals Gene Causing Disorder
10. ACS Webinar features tips for using a chemistry degree in finding career opportunities
11. Young hunters most likely to be injured using tree stands, say UAB researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
(Date:10/12/2017)... ... 12, 2017 , ... The company has developed a suite ... regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been developed ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, ...
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a ... of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners ... October 11, 2017. , The annual award competition recognizes editorial and design excellence across ...
(Date:10/12/2017)... GRAND RAPIDS, Mich. (PRWEB) , ... October 12, ... ... OnSite Wellness, has been named one of Michigan’s 2017 Best and Brightest in ... Best and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  BioPharmX Corporation (NYSE MKT: ... that developed an innovative way to use nonlinear optical ... delivery of new drugs. ... Dermatology Conference will show how researchers from BioPharmX and ... Medical School used a suite of imaging techniques in ...
(Date:10/10/2017)... Pa. , Oct. 10, 2017   West ... in innovative solutions for injectable drug administration, today shared ... West,s ID Adapter for improving the intradermal administration of ... Fourth Skin Vaccination Summit in May 2017 by Dr. ... Lead, Polio Department, World Health Organization (WHO), and recently ...
(Date:10/4/2017)... , Oct. 4, 2017 OBP ... self-contained, illuminating medical devices, today announced regulatory approval ... Surveillance Agency (or Agência Nacional de Vigilância Sanitária ... single-use, cordless surgical retractor with integrated LED light ... access, illumination and exposure of a tissue pocket ...
Breaking Medicine Technology: