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Using additional biopsy-scoring data may help determine prostate cancer prognosis
Date:10/2/2007

Men with certain scores and patterns based on prostate cancer biopsy were found to be at higher risk of PSA-failure, suggesting that this measurement could help predict the risk of prostate cancer recurrence, according to preliminary research published in the October 3 issue of JAMA.

One of the tools used for the diagnosis and treatment of prostate cancer is the Gleason scoring system, which grades adenocarcinomas (malignant tumors) of the prostate based on the patterns of prostatic glands. Many studies have confirmed the prognostic significance of the Gleason score with respect to time to recurrence and death following therapy, according to background information in the article. The Gleason scoring system assigns a grade of 1 to 5 (higher grade being less differentiated) to the predominant pattern and to the second most prevalent pattern in the prostate specimen. The two grades are summed to arrive at a final score between 2 and 10. Although the Gleason scoring system does not incorporate a third pattern, the presence of more than two Gleason patterns in an individual tumor is widely recognized to occur and many pathologists use a tertiary (third) pattern.

Abhijit A. Patel, M.D., Ph.D., of Brigham and Womens Hospital and the Dana Farber Cancer Institute, Boston, and colleagues conducted a study to compare the prognostic significance of Gleason score 7 with tertiary grade 5 vs. other Gleason scores with respect to time to prostate-specific antigen (PSA) failure (an increase in the blood level of PSA after prostate cancer treatment with surgery or radiation). From 1989 to 2005, 2,370 men with various tumor grades and prostate cancer that had not spread to nearby lymph nodes or elsewhere in the body, underwent therapy with surgery or radiation therapy with or without hormonal therapy. Gleason scores were assigned to the prostate needle biopsy specimens.

The researchers found that men with Gleason score 7 and tertiary grade 5 disease ha
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Contact: Lori Shanks
617-534-1604
JAMA and Archives Journals
Source:Eurekalert

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