Navigation Links
Using a small stockpile of a secondary antiviral drug in a flu pandemic
Date:4/30/2009

In a global influenza pandemic, small stockpiles of a secondary flu medication if used early in local outbreaks could extend the effectiveness of primary drug stockpiles, according to research made available today ahead of publication in PLoS Medicine.

Many countries are investing in large stockpiles of a single drug, oseltamivir (Tamiflu). But influenza viruses can become resistant to antiviral drugs, and the widespread use of a single drug is likely to increase the risk that a resistant strain will emerge. If such a strain were to spread widely, the effectiveness of antiviral drugs in treating infected patients, as well as their ability to slow the spread of a pandemic, would be greatly reduced.

Using a mathematical model to represent the global spread of pandemic influenza, an international team of researchers led by Joseph Wu of the University of Hong Kong, and including collaborators in the UK and the US, found that treating as few as only the first 1% of the population in a local epidemic with a secondary drug rather than with oseltamivir, could substantially delay the development of resistance to oseltamivir. This reduction in resistance was predicted to benefit not only local populations, but also those in distant parts of the world where the pandemic would subsequently spread through air travel.

In the context of the currently emerging swine flu, the secondary drug could be zanamivir (Relenza), the only other approved drug to which the new H1N1 strain has been found to be susceptible.

This strategy is predicted to be effective because it delays use of the primary stockpiled drug until a certain proportion of the local population (about 1.5% according to the model) has been infected with virus that remains susceptible to the primary drug. With drug-sensitive virus in the majority as people recover from infection and develop immunity, only a minority of further infections are likely to be resistant to the primary drug.

Technically, such a delay could be achieved by postponing the launch of any antiviral intervention. However, because even a short delay would mean denying antiviral drugs to people who would benefit from them, the researchers instead propose the deployment of a small stockpile of a secondary antiviral during the early phase of the local epidemic.

The model, prepared before the current swine flu crisis, considered two possible strategies, "early combination chemotherapy" (treatment with two drugs together while both are available, assuming that clinical trials show such a combination to be safe for patients) and "sequential multi-drug chemotherapy" (treatment with the secondary drug until its stockpile is exhausted, then treatment with the primary drug). While either strategy could be effective in principle, only the sequential strategy would be practical in responding to the currently emerging H1N1 swine flu, because the safety of combining zanamivir with oseltamivir (for combination therapy) is not established.

After simulating the impact of these strategies in a single population, the researchers then introduced international travel data into their model to investigate whether these two strategies could limit the development of antiviral resistance at a global scale. This analysis predicted that, provided the population that was the main source of resistant strains used one of the strategies, both strategies in distant, subsequently affected populations would be able to reduce the consequences of resistance, even if some intermediate populations failed to control resistance.


'/>"/>

Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
Source:Eurekalert

Related medicine news :

1. Researchers to Monitor Public Perception of Swine Flu Outbreaks Using Technology from Realtime Search Engine, OneRiot
2. New Medical Study Establishes First-Ever Long-Term Benefits for Macular Degeneration Sufferers Using Macular Health Vitamin Supplement
3. WaferGen and Leading Academic Medical Center Establish Genotyping Research Collaboration to Validate SNPs in Breast Cancer Using SmartChip(TM) Real-Time PCR System
4. Kaiser Family Foundation Launches Daily Global Health Policy Report and Policy Tracking Tool As Part of New Web Gateway Focusing on U.S. Global Health Policy
5. Movero Delivers Over 10,000 Training Sessions for Physicians Using Mobile ePrescription Applications
6. Early-stage lung cancer identified using computer-aided system
7. Three Million People Now Using Kaiser Permanentes Personal Health Record
8. Worlds First Disposable Wireless RFID Sensor Detects Radiation Threats in Shipping Containers Using Modified Cell Phone Technology
9. Using tools requires that the brain is able to control movements
10. Yashoda Cancer Institute Treats First Patient in India Using RapidArc Radiotherapy Technology
11. Using Public Relations to Launch, Grow and Extend Your Brands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... May 31, 2016 , ... The Orthopaedic Research and Education Foundation ... , David G. Lewallen, MD, began his term as president in March, succeeding John ... MD, is OREF’s new president-elect. Richard F. Kyle, MD, will serve as chair, corporate ...
(Date:5/31/2016)... ... May 31, 2016 , ... MinerEye today announced that ... Infrastructure Protection report by Gartner1 Inc. , Each year, Gartner identifies new Cool ... these innovative vendors and their products and services. , According to Gartner, “Gartner's ...
(Date:5/31/2016)... Port Washington, NY (PRWEB) , ... May 31, 2016 , ... ... and other essential nutrients to on the go individuals and dedicated athletes, continues to ... functions. , Loaded with whey, pea and milk protein, branched-chain amino acids (BCAA), ...
(Date:5/30/2016)... ... 30, 2016 , ... Another ER facility operated by First Choice Emergency ... Drive, Plano, TX and is open 24 hours daily. , First Choice Emergency Room ... open house. The Jasper High School band entertained attendees and accepted First Choice Emergency ...
(Date:5/28/2016)... Viejo, California (PRWEB) , ... May 28, 2016 , ... ... need to drag and drop a preset onto their media," said Christina Austin - ... Pixel Film Studios, editors can quickly and easily add stylish color grades to their ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... -- Amarantus BioScience Holdings, Inc. (OTCQX: ... Medicine, Neurology and Orphan Diseases, today announced that President & CEO ... investor conferences: SeeThru Equity MicroCap Conference   ... York City , NY When: Tuesday, May 31 ...   Where: Grand Hyatt Hotel, 109 East 42 nd ...
(Date:5/26/2016)... May 26, 2016 A key ... is the emergence of new treatments. Cardax, a development ... osteoarthritis treatment. The therapy is expected to fulfil large ... UK is conducting studies to develop new treatments for ... the genes involved in osteoarthritis are being investigated, and ...
(Date:5/26/2016)... , May 26, 2016 Since ... matured into an essential life science tool for conducting ... applications. BCC Research reveals in its new report that ... growth phase, one powered by a range of new ...      (Logo: http://photos.prnewswire.com/prnh/20140723/694805 ) , ...
Breaking Medicine Technology: