Navigation Links
Using MRI, researchers may predict which adults will develop Alzheimer's
Date:4/5/2011

OAK BROOK, Ill. Using MRI, researchers may be able to predict which adults with mild cognitive impairment are more likely to progress to Alzheimer's disease, according to the results of a study published online and in the June issue of Radiology.

Mild cognitive impairment (MCI) is an intermediate stage between the decline in mental abilities that occurs in normal aging and the more pronounced deterioration associated with dementia, a group of brain disorders that includes Alzheimer's disease (AD).

Individuals with MCI develop AD at a rate of 15 to 20 percent per year, which is significantly higher than the one to two percent rate for the general population. Some people with MCI remain stable while others gradually decline and some quickly deteriorate.

"Being able to better predict which individuals with MCI are at greatest risk for developing Alzheimer's would provide critical information if disease-modifying therapies become available," said the study's lead author, Linda K. McEvoy, Ph.D., assistant professor in the Department of Radiology at the University of California, San Diego School of Medicine.

Dr. McEvoy and a team of researchers analyzed MRI exams from the Alzheimer's Disease Neuroimaging Initiative (ADNI), a large publicly and privately sponsored study, which performed imaging and other tests on hundreds of healthy individuals and others with MCI and early AD between 2005 and 2010 in hopes of identifying valuable biomarkers of the disease process.

Included in the study were a baseline MRI exam, serving as an initial point of measurement, and a second MRI performed a year later on 203 healthy adults, 317 patients with MCI and 164 patients with late-onset AD. The average age of the study participants was 75.

Using MRI, the researchers measured the thickness of the cerebral cortex the outermost layer of the cerebral hemispheres of the brain that plays a key role in memory, attention, thought and language and observed the pattern of thinning to compute a risk score. One of the characteristics of AD is a loss of brain cells, called atrophy, in specific areas of the cortex.

"MRI is very sensitive to brain atrophy," Dr. McEvoy said. "There's a pattern of cortical thinning associated with AD that indicates the patient is more likely to progress to AD."

Using the baseline MRI, the researchers calculated that the patients with MCI had a one-year risk of conversion to AD ranging from three to 40 percent.

"Compared to estimating a patient's risk of conversion based on a clinical diagnosis only, MRI provides substantially more informative, patient-specific risk estimates," Dr. McEvoy said. "The baseline MRI helped identify which patients were at very low risk of progressing to Alzheimer's and those whose risk was doubled."

By combining results of the baseline MRI and the MRI exam performed one year later, the researchers were able to calculate a rate of change in brain atrophy that was even more informative. The MCI patients' risk of disease progression based on the serial MR exams ranged from 3 to 69 percent.

"Rapid thinning of the cortex is reflective of a degenerative disorder," Dr. McEvoy explained.

Although no treatments currently exist that slow or prevent the neurodegeneration associated with AD, Dr. McEvoy said patients at high risk of progressing to AD might want to enroll in clinical trials of disease-modifying therapies. She said the information would also help ensure patients receive optimal care and allow families more time for planning.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Results show benefits in using acute kidney injury criteria in the diagnosis of cirrhosis
2. Detection of early gastric cancer using hydro-stomach CT
3. U of M researchers using salmonella to fight cancer
4. Using Electronics Before Bed May Hamper Sleep
5. Using a molecular switch to turn on cancer vaccines
6. Using amphetamines may increase risk of Parkinsons disease
7. A new high-resolution method for imaging below the skin using a liquid lens
8. Using Cell Phones Might Evoke Emotions, Study Suggests
9. Children in public housing play outdoors more
10. Using chlorhexidine gluconate baths to reduce hospital-acquired infections
11. UT Southwestern launches clinical trial for treatment of breast cancer using CyberKnife
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2017)... ... 2017 , ... Chuck E. Cheese’s® and Center for Autism and Related Disorders ... E. Cheese’s locations throughout New England, New York and New Jersey to provide children ... fun of visiting Chuck E. Cheese’s in a sensory-friendly environment. , After a ...
(Date:2/19/2017)... ... , ... ProBrand Glitch is a set of 30 glitch distortion logo reveals made exclusively for ... logo with a glitch reveal in just a few clicks of a mouse. Customizable glitch ... each preset. Use these presets to add a uniquely animated logo to any photos or ...
(Date:2/18/2017)... ... 2017 , ... Butler Mobility invited Ken Matthews to visit its manufacturing facility ... Ken was impressed with the safety and reliability of the Stannah Stairlift as well ... This endorsement by Ken Matthews can be heard on News Radio WHP 580 ...
(Date:2/17/2017)... ... , ... Smiles by Seese is a comprehensive family dental practice ... the practice as a skilled and highly credentialed dentist who is qualified to perform ... of all ages with excellence in general, restorative, and cosmetic dentistry . Their ...
(Date:2/17/2017)... (PRWEB) , ... February 17, ... ... Device Approval and Reimbursement , **An FDAnews Webinar**, Feb. 22, 2017 — ... are the critical reimbursement questions manufacturers should be asking before selecting an ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... February 20, 2017 The ... anticipated to reach USD 1.4 billion by 2022, ... Research, Inc. Constant evaluation of various techniques by ... to drive growth in this market. Moreover, shunt ... of novel and improved shunts in order to ...
(Date:2/20/2017)... COTTAGE, New York , February 20, 2017 /PRNewswire/ ... a regularized absorption of calcium and phosphorous minerals in ... role of vitamin D ingredients in maintaining a healthy ... or medicines containing vitamin D ingredients is growing in ... the advantage of consuming vitamin D ingredients for treatment ...
(Date:2/19/2017)... --  AC Group Inc. , a leading company, specializing ... the PMS/EHR healthcare marketplace, will exhibit the 7 Stages ... in this ecosystem at HIMSS,17. ... over 200 ACOs, compared and analyzed an ACO,s needs ... are providing different pieces of Population Health technologies designed ...
Breaking Medicine Technology: