Navigation Links
Using Drug for Prevention Might Help in Hard-to-Treat Hemophilia
Date:11/2/2011

o see if bypassing agents might prevent bleeds in this subset of patients in the same way that factor VIII concentrates successfully prevent bleeds in people without inhibitors.

Thirty-four patients over the age of 2 were randomly assigned to receive either six months of preventive thrice-weekly FEIBA (also known as AICC or anti-inhibitor coagulant complex) or to receive on-demand therapy.

After a three-month "washout" period, the groups were switched.

Twenty-six participants completed the study. The bleeding rates were reduced by 62 percent in the prophylaxis group compared to the on-demand groups.

Even patients with the most severe disease saw benefits, with the average number of bleeding episodes decreasing from 3.8 to 1.1 in the seven patients who had the most frequent bleeding before the study. Two of these individuals had no bleeding at all during the study period.

There was one allergic reaction to FEIBA, while several participants had complications from the hemophilia: Two adults died from bleeding episodes and two experienced brain bleeds.

Cost remains a significant issue.

Using the bypassing agent prophylactically would cost more than double what it would for on-demand (nearly $500,000 versus nearly $210,000 per patient in this study), the authors said, although these calculations didn't subtract for hospitalizations avoided and prevention of long-term complications.

"The cost is so extreme but the benefits are pretty extreme, too," said Harrington. "Three times a week is very, very costly [both for factor VIII concentrates and bypassing agents] but it keeps the joints healthy and provides good quality of life so these people can live normal lives."

FEIBA is licensed in the United States for on-demand treatment of hemophilia only. According to study author Dr. Cindy Leissinger, Baxter BioScience has started a study that "I feel quite sure is being done with a labeling indication in mind."


'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

0

GOOD

Page: 1 2 3

Related medicine news :

1. Ecumen Building Senior Housing in Apple Valley, Minnesota and Will Manage New Maplewood, Minnesota Property
2. Using gold nanoparticles to hit cancer where it hurts
3. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
4. Register Online for this Year's Horst Senior Living Conference on April 8 Featuring Keynote Speaker and Senior Housing Expert Jim Moore
5. Rockland County Landlord Agrees to Settlement With United States to Protect Fair Housing Rights of Tenants With Mental Disabilities
6. Groundbreaking Study Using Ultrasound for the Treatment of Intracerebral and Intraventricular Hemorrhage Stroke Shows Promise
7. SDI Reports: Nearly a Third Of Physicians Use Handheld and Smartphone Devices to Access Medical Information - Physicians Most Likely to be Using Apple iPhone
8. Parrish Medical Center Sees 30 Percent Improvement in Mortality Using Real-Time Clinical Surveillance Solution from Thomson Reuters
9. Family history is strong predictor of obstructive coronary artery disease using CCTA
10. Using new approach, Mayo Clinic researchers find level of gene alters risk of Alzheimers disease
11. Best Selling, Non Toxic Skin Brightener Does the Job Using Safe, Healthy Ingredients and Introduces New Anti Aging Ingredients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Using Drug for Prevention Might Help in Hard-to-Treat Hemophilia
(Date:5/24/2013)... (HealthDay News) -- Drugs commonly used to treat glaucoma ... can interfere with vision, according to a new study. ... are used to reduce eye pressure, have already been ... eye color, the researchers said, suggesting that the new ... Doctors should be conservative when prescribing these drugs, ...
(Date:5/24/2013)... researchers failed to replicate what appeared to be breakthrough ... they were published last year in the journal ... 2012, suggested that the drug bexarotene (marketed as Targretin) ... (Aβ) a pathological hallmark of Alzheimer,s disease ... of the 2012 report, drug treatment quickly removed most ...
(Date:5/24/2013)... New York, New York (PRWEB) May 24, 2013 ... da Vinci lawsuit involving Intuitive Surgical Inc.’s da ... According to court records, a Washington State Court ... not committed negligence in training a surgeon who performed ... several years later. The patient’s family had alleged ...
(Date:5/24/2013)... 24, 2013 Dwell Media LLC ... Huff as Executive Vice President of Digital for Dwell ... which represented a large portion of Yahoo's global media ... Dwell develops a fully-integrated commerce unit to launch in ... monetizing digital content for leading firms in Silicon Valley. ...
(Date:5/24/2013)... 24 (HealthDay News) -- People with high levels of ... die of liver disease than those with lower levels, ... cadmium in urine is evidence of long-term exposure to ... and tobacco smoke, the Johns Hopkins researchers explained. ... cadmium directly causes liver disease but instead suggest an ...
Breaking Medicine News(10 mins):Health News:Common Glaucoma Drug May Cause Droopy Eyelids, Study Finds 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 3Health News:Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on Verdict in Nation’s First Trial Involving Alleged Da Vinci Complications 2Health News:Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on Verdict in Nation’s First Trial Involving Alleged Da Vinci Complications 3Health News:Yahoo Commerce Head Joins Leadership at Dwell Media 2Health News:High Cadmium Levels May Raise Risk for Dying From Liver Disease: Study 2
... Increased roadway pollution produced by diesel fuel in vehicles ... result in heart attack or stroke, researchers suggested in ... American Heart Associations Scientific Sessions 2007., United Kingdom and ... and blood platelet activity in healthy volunteers which ...
... danger, study suggests , , TUESDAY, Nov. 6 (HealthDay News) ... and could pose risks to people with hypertension and ... found that drinking two cans of a popular energy ... healthy adults, average age 26. , Within a few ...
... of antioxidants, vitamins and electrolytes offer healthiest ... benefits in new functional water, PLANO, ... a one-two punch, Snapple,s introduction of Antioxidant Water and,LYTeWater takes drinking ... offers a smart solution that,improves energy, helps restore the body and ...
... Nov. 6 Neurotech Pharmaceuticals, Inc.,a biotechnology ... for chronic retinal diseases, announced today the ... Each study is evaluating,NT-501, the Company,s lead ... with retinitis pigmentosa (RP) and the dry ...
... SEATTLE, Nov. 6 On Thursday, November 8,2007, at ... Cell Therapeutics, Inc.,s (CTI) (Nasdaq: CTIC and ... to discuss the,company,s 2007 third quarter achievements and financial ... November 8 8:30 a.m. Eastern/2:30 p.m. Central ...
... CALL AND WEBCAST TO FOLLOW, BIRMINGHAM, Ala., Nov. ... announced that its third quarter,2007 financial results will be ... Time, BioCryst will host a conference call and live,webcast. ... President and Chief,Executive Officer, and Stuart Grant, Senior Vice ...
Cached Medicine News:Health News:Diesel exhaust associated with higher heart attack, stroke risk in men 2Health News:Diesel exhaust associated with higher heart attack, stroke risk in men 3Health News:Energy Drinks Could Pose Blood Pressure Risks 2Health News:Snapple's New Antioxidant Water and LYTeWater Take Hydration to the Next Level 2Health News:Snapple's New Antioxidant Water and LYTeWater Take Hydration to the Next Level 3Health News:Neurotech Announces Completion of Enrollment of its Phase II/III Retinitis Pigmentosa and Phase II Dry Age Related Macular Degeneration Clinical Studies 2Health News:Neurotech Announces Completion of Enrollment of its Phase II/III Retinitis Pigmentosa and Phase II Dry Age Related Macular Degeneration Clinical Studies 3Health News:BioCryst to Release Third Quarter 2007 Financial Results on Thursday, November 8, 2007 2Health News:BioCryst to Release Third Quarter 2007 Financial Results on Thursday, November 8, 2007 3Health News:BioCryst to Release Third Quarter 2007 Financial Results on Thursday, November 8, 2007 4
(Date:5/23/2013)... , May 23, 2013 Anthem Blue ... that would have required them to obtain their medications ... Consumer Watchdog and Whatley Kallas LLC.  ... Court, alleged that Blue Cross,s mandatory mail order program ... their health and privacy. "This settlement brings ...
(Date:5/23/2013)... , May 23, 2013  Hologic, Inc. ... ), a leading developer, manufacturer and supplier of ... with an emphasis on serving the healthcare needs ... observational study in a U.S. clinical practice comparing ... (breast tomosynthesis) with conventional 2D mammography alone showed ...
(Date:5/23/2013)... , May 23, 2013  Ameritox, the ... selected by Progressive Medical, Inc. to become part ... help clients manage pharmacy costs and improve the ... Medical, a leading pharmacy benefit manager in the ... overall medication compliance and pain management strategy for ...
Breaking Medicine Technology:Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog 2Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers 2Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers 3
... 2011 GlaxoSmithKline (GSK) is committed to ensuring that ... and alli. alli is safe and effective when used ... and works locally in the gastro-intestinal tract. GSK continues ... share all relevant information with regulatory agencies. ...
... April 14, 2011 Freedom Innovations, a company ... lower extremity prosthetic devices, today announced a worldwide ... rights to commercialize the world,s first lower extremity ... that operate synergistically.  Developed at the Vanderbilt University ...
Cached Medicine Technology:Freedom Innovations to Commercialize the World's First Actively-Powered, Complete Lower Extremity Prosthesis 2Freedom Innovations to Commercialize the World's First Actively-Powered, Complete Lower Extremity Prosthesis 3
... Durable ergonomic chairs with concave seats ... • Select options like seats, backrests, ... Choose the BE Series for top ... including: industry, education, laboratory, clean room, ...
... Durable ergonomic chairs with concave ... support • Select options like seats, ... • Choose the BE Series for ... environments including: industry, education, laboratory, clean ...
... ergonomic chairs with concave seats and ... Select options like seats, backrests, armrests, ... the BE Series for top performance ... industry, education, laboratory, clean room, static ...
... concave seats and large backrests with ... seats, backrests, armrests, and casters and ... for top performance in a variety ... clean room, static control, health care ...
Medicine Products: