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Use of lubricants with anal sex could increase risk of HIV
Date:5/25/2010

ad toxic effects on the cells and rectal tissue studied. Some of the lubricants caused significant portions of the epithelium the layer of cells that serves as a protective barrier inside the rectum to be stripped away. Conclusions cannot be made based on this study alone, though the results are compelling enough to wonder if these lubricants might have the same effect in people and thereby increase susceptibility to HIV, commented Charlene Dezzutti, Ph.D., from the University of Pittsburgh and Magee-Womens Research Institute, who led the study for the Microbicide Trials Network. The study, which was conducted in collaboration with International Rectal Microbicides Advocates (IRMA), was undertaken because little is known about the safety of lubricants even though they are frequently used during anal sex.

Six products were studied. Five (Astroglide, Elbow Grease, ID Glide, KY Jelly and Wet Platinum) were selected because they had been identified as those most commonly used by the more than 6,300 respondents to an IRMA survey. The sixth product (PR) was selected to serve as a control because it is isomolar. Osmolarity refers to the concentration of dissolved particles (salts and sugars) found inside a cell relative to the outside. A product that is isomolar has the same concentration of particles as inside the cell, whereas a product that is hyperosmolar has a higher concentration of salts and sugars relative to the cell. To correct this imbalance, a cell forces water out but then it becomes withered and dies. Most of the lubricants studied were water-based, except for Wet Platinum, which is a condom-compatible silicone-based product. The researchers characterized each product according to its osmolarity, pH and viscosity or slipperiness. Studies then were conducted to determine the effect of each lubricant on different cell types, rectal and cervical tissue and on bacteria (microorganisms that are important to the health of the rectum). Based on the te
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Contact: Lisa Rossi
rossil@upmc.edu
412-916-3315
Microbicides 2010 (International Conference on Microbicides)
Source:Eurekalert

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