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Use of iodinated contrast media in imaging procedures appears to affect thyroid function
Date:1/23/2012

e and the known sequelae of thyroid functional derangements, further studies are needed to confirm and evaluate generalizability of these findings, to establish causality and to explore mechanisms."

Invited Commentary: Iodine-Induced Thyroid Dysfunction

In an accompanying invited commentary, Elizabeth N. Pearce, MD, MSc, of Boston University School of Medicine writes that Rhee et al "describe significant associations between contrast exposure and the development of hyperthyroidism. While no overall association exists between contrast exposure and all forms of hypothyroidism, an association was noted when cases were restricted to those with overt hypothyroidism."

"These data represent an important contribution to our knowledge about a clinically relevant and understudied area," Pearce writes. "Rhee et al have demonstrated that a relatively large proportion of individuals who developed iodine-induced thyroid dysfunction were not known to have underlying risk factors. Therefore, patients who may be particularly unable to tolerate thyroid dysfunction, such as those with underlying unstable cardiovascular disease, are also good candidates for monitoring of thyroid function after iodine exposure."


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