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Use of frozen material for fecal transplant successfully treats C. difficile infection
Date:4/23/2014

pants who received the second infusion were allowed to choose the route of administration, and all chose to receive it via NGT.

Subsequently the researchers discovered that the participant who declined a second infusion was self-administering fecal enemas, using unprocessed material from his roommate, a practice Hohmann notes could be hazardous. "We certainly don't recommend 'home brew' FMT, since it's very important to screen donors properly. In addition, while some people may be comfortable using stool from a spouse or other intimate partner, many older patients might not have such a donor who is healthy enough to donate safely."

The research team also reports treating an additional 11 patients with frozen donor samples via NGT, achieving a 91 percent success rate, and they currently are investigating what may be an even more acceptable means of administration via a capsule that would remain undigested until it reaches the small intestine.

"It's been very gratifying to be able to help these patients, some of whom have been sick for a year or two," Hohmann explains. "They have told us this has been life changing for them and that they have gotten themselves back to normal. There aren't many things in medicine that have a success rate of more than 90 percent. Insurers may not want to pay for this, but it is very effective, makes patients better quite quickly and saves money overall. While it may never become a first-line treatment, we are starting to consider using it more and more often," she adds.


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Contact: Kristen Chadwick
kschadwick@partners.org
617-643-3907
Massachusetts General Hospital
Source:Eurekalert

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