Navigation Links
Use of frozen material for fecal transplant successfully treats C. difficile infection
Date:4/23/2014

in check.

FMT probably treats C. difficile by restoring the normal balance of intestinal microbes. Previous animal and human FMT studies using fresh fecal material have had success rates of around 90 percent, but the MGH researchers note that recruiting and screening potential donors can be time-consuming and costly. Banking a supply of frozen, prescreened donor stool could significantly increase the availability of FMT, and the current study was designed to test the feasibility and effectiveness of such an approach, along with comparing two routes for delivery of the donor material.

Stool samples were donated by exceptionally healthy adults who received comprehensive screening for infectious diseases. Donors also were asked to refrain from eating any common allergens, such as nuts or eggs, in the days before donation. The donated fecal material was filtered, diluted, screened and frozen; stored for at least four weeks to allow retesting donors for any hidden infections; and prior to administration, thawed and kept refrigerated.

The study enrolled 20 patients three of whom were children who either had three or more episodes of mild to moderate C. difficile infection for which antibiotic treatment failed or had two episodes serious enough to require hospitalization. Participants were randomly divided into two groups 10 who received donor material by standard colonoscopy and 10 who received it though a nasogastric tube (NGT) passed into the stomach. A single administration was successful in curing 14 of the 20 participants 8 in the colonoscopy group and 6 in the NGT group, a difference not considered significant in such a small study.

Among those whose infections did not resolve, a single participant declined additional treatment. The other 5 received a second administration, which cured the infection in 4, for an overall success rate of 90 percent, similar to that of the previous studies. Partici
'/>"/>

Contact: Kristen Chadwick
kschadwick@partners.org
617-643-3907
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Frozen Bakery Additives Market (Preservative, Oxidizing Agent, Reducing Agent, Enzyme, Emulsifier) Worth $1.46 Million by 2018 - New Report by MarketsandMarkets
2. Demas Law Group Files Claim Against Townsend and Costco in Frozen Berries Case
3. FrozenPeaz Sponsors Salt Lake International Speedskating Team and Lana Gehring inTheir Quest for Olympic Gold
4. Frozen Food Production in China Industry Research Report – Now Available from IBISWorld
5. FrozenPeaz Launches Pre-habilitation Marathon Training Recovery Promotion
6. Frozenshoulder.com, New Research Shows Increase in Shoulder Injuries Due to Airline Baggage Regulations
7. New Zinga Frozen Yogurt Opens in Falls Church
8. 49 Now Sickened in Hepatitis A Outbreak Tied to Frozen Berry Mix
9. Frozen Food Production in the US Industry Market Research Report from IBISWorld has Been Updated
10. Zinga! Frozen Yogurt Touts Harvard Study for National Nutrition Month
11. Puppy Born From Frozen Embryo May Offer Hope to Endangered Wildlife
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Cut Pro X plugin developers have announced a new anamorphic ... “ProBlue 5k is a compilation of anamorphic flares that can ... Austin, CEO of Pixel Film Studios. “Blurring the line between ... , ProBlue 5k is the ultimate Ultra High Definition anamorphic ... compilation of over 100 anamorphic flares can be applied to ...
(Date:9/17/2014)... who struggle to distinguish between a business strategy and business ... the answer by reading Per Wickstrom’s latest blog post. , ... plan and a business strategy are both strategic – and ... I view it is that a business plan is part ... , According to the blog post, a business plan ...
(Date:9/17/2014)... 17, 2014 The Oliver Law Group ... allegedly caused by Non-Sterile Other-Sonic Ultrasound Transmission Gel ... their options for legal recourse. Other-Sonic ultrasound gel was ... in March 2012, after the product was linked to ... Beaumont Hospital in Royal Oak, Michigan . While victims ...
(Date:9/17/2014)... HealthDay Reporter WEDNESDAY, ... womb to household chemicals known as phthalates might increase ... researchers reported in a new study. Children had ... between age 5 and 11 if their mothers were ... (pronounced thal-ates), the researchers found. The two phthalates were ...
(Date:9/17/2014)... FRISCO, Texas (PRWEB) September 17, 2014 ... (EV-D68) outbreak that is hospitalizing scores of infants, children ... Louisiana, says Dr. Kirk Mahon, medical director of Legacy ... , “There have been no reported cases of EV-D68 ... Oklahoma and Louisiana, that could change,” he said. “Implementing ...
Breaking Medicine News(10 mins):Health News:A New Plugin Entitled ProBlue 5k Was Released Today from Pixel Film Studios Exclusively for Final Cut Pro X 2Health News:Per Wickstrom’s Latest Blog Explores the Difference Between a Business Plan and a Business Strategy 2Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 2Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 3Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 4Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 2Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 3Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 4Health News:Legacy ER & Urgent Care Warns North Texans about Dangers of Enterovirus D68 2
... , , , , , NEW YORK, ... of a letter of intent for a strategic alliance with Rusan ... Rusan providing Rx for Africa Inc. the tuberculosis (TB) drug, "RUCOX-4" ... World Health Organization (WHO), which is also approved by the Ethiopian ...
... ,Performance Excellence and Accountability in Kidney Care, to reduce mortality ... 2012 - , , WASHINGTON, June 8 ... quality improvement campaign pledging to reduce mortality among first-year dialysis ... percent by the end of 2012. , ...
... Hispanics - the "invisible" Boomers - Face Workplace Challenges , ... play a dynamic role in helping solve long-term challenges for many ... according to a new AARP report, being released today at AARP,s ... http://www.newscom.com/cgi-bin/prnh/20070209/NYF043LOGO ) , , ...
... , Aspirin a Day, Other Services Cited , in ... 8 As Congress tackles health reform, a new public education ... year by investing in five basic preventive services. That includes 45,000 ... benefit were advised by their doctors to take a daily dose ...
... PHOENIX, June 8 Summer can be a fun time of year, ... Plan Arizona encourages area seniors to take extra precautions this season with ... Prevent sunburn. Applying sunscreen ... prior to going out, everyday. Reapply every two to four hours, more ...
... and Rochester , N.Y. ... New Reports from HealthLeaders-InterStudy , , NASHVILLE, Tenn., ... market intelligence, reports that medical home pilot initiatives across the ... such programs can save money by directing care more efficiently. ...
Cached Medicine News:Health News:Rx for Africa, Inc. Signs Letter of Intent for Strategic Alliance with Rusan Pharma, Ltd. of India 2Health News:Rx for Africa, Inc. Signs Letter of Intent for Strategic Alliance with Rusan Pharma, Ltd. of India 3Health News:Kidney Care Partners Launches Health Care Campaign to Improve Survival Rates of First-Year Dialysis Patients 2Health News:Kidney Care Partners Launches Health Care Campaign to Improve Survival Rates of First-Year Dialysis Patients 3Health News:Hispanic Workers Ages 50+ May Help Employers Solve Potential Future Labor Shortages 2Health News:Hispanic Workers Ages 50+ May Help Employers Solve Potential Future Labor Shortages 3Health News:U.S. Could Save 100,000 Lives a Year with Five Basic Preventive Services 2Health News:SCAN Health Plan Arizona Encourages Sun Smarts and Plenty of Water for Seniors This Summer 2Health News:Medical Home Pilot Initiatives Continue to Expand Nationwide 2Health News:Medical Home Pilot Initiatives Continue to Expand Nationwide 3
(Date:9/17/2014)... 2014  Aratana Therapeutics, Inc. (NASDAQ: ... licensing, developing and commercializing innovative biopharmaceutical products for ... public offering of 4,500,000 shares of its common stock at ... share. Aratana has granted the underwriters a 30-day ... shares of its common stock. Jefferies ...
(Date:9/17/2014)... Calif. , Sept. 17, 2014 ... announced that it has earned a $4 million ... AKAO ) associated with the initiation of a ... serious multi-drug resistant (MDR), gram-negative bacterial infections.  The ... study to evaluate the efficacy and safety of ...
(Date:9/17/2014)... MILL VALLEY, Calif. , Sept. 17, ... announced a partnership in the fight against sarcoma. ... Sarcoma Alliance Suzanne Renee Leider Memorial Assistance Fund. ... assistance to reimburse sarcoma patients for expenses directly ... sarcoma specialist. Scientific literature reinforces the importance of ...
Breaking Medicine Technology:Aratana Therapeutics, Inc. Announces Pricing of Public Offering 2Isis Pharmaceuticals Earns $4 Million from Achaogen for the Initiation of a Phase 3 Study of Plazomicin 2Isis Pharmaceuticals Earns $4 Million from Achaogen for the Initiation of a Phase 3 Study of Plazomicin 3Champions Oncology Partners with Sarcoma Alliance to Bring Personalized Treatment Options to Sarcoma Patients 2Champions Oncology Partners with Sarcoma Alliance to Bring Personalized Treatment Options to Sarcoma Patients 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: