Navigation Links
Use of Smokers' Lungs for Transplant Has Pros, Cons
Date:5/29/2012

TUESDAY, May 29 (HealthDay News) -- Should the lungs of smokers be included in lung transplants? A new study suggests their inclusion may be warranted.

The study found that lung transplant patients who receive smokers' lungs still are more likely to survive than those who refuse such lungs and remain on the transplant waiting list.

The lives of patients who receive smokers' lungs, however, tended to be shorter than those who receive the lungs of non-smokers, the British researchers added. Given the evidence, however, Britain's policy of using smokers' lungs for transplant should be continued, according to the authors of the study published online May 28 in The Lancet.

The issue is not just a British one -- speaking to the Associated Press, Dr. Normam Edelman, chief medical officer for the American Lung Association, said smokers' lungs are also used for transplant in the United States, although he did not have data on how common the practice might be.

But the bottom line from the new study is that "patients awaiting lung transplantation in the U.K. are likely to survive longer if they are willing to accept lungs from any suitable donor, irrespective of smoking history," lead author Dr. Robert Bonser, of the Queen Elizabeth Hospital in Birmingham and the University of Birmingham, said in a journal news release. "Donors with a positive smoking history provide nearly 40 percent of the lungs available for transplantation [in the U.K.] Rejection of this donor-organ resource would increase waiting-list mortality and is ill-advised."

Bonser and his colleagues examined the survival rates for nearly 2,200 adult patients in the United Kingdom awaiting lung transplants between 1999 and 2010. Of the nearly 1,300 lung transplants that took place during that time, about two in every five came from donors with a history of smoking.

Patients who received smokers' lungs were 46 percent more likely to have died three years after transplantation than those who received lungs from non-smokers. However, patients who received smokers' lungs also were 21 percent less likely to die than those who remained on the waiting list.

The researchers also found that including smokers' lungs in the donor pool increased the likelihood of survival by 61 percent for patients with fibrosis and by 40 percent for those with septic lung disease.

"Although lungs from such donors are associated with worse outcomes, the individual probability of survival is greater if they are accepted than if they are declined and the patient chooses to wait for a potential transplant from a donor with a negative smoking history," the authors wrote. "This situation should be fully explained to and discussed with patients who are accepted for lung transplantation."

One expert in the United States said the study "raises a few issues."

Dr. Len Horovitz, pulmonary specialist at Lenox Hill Hospital in New York City, said that "because many patients may die awaiting transplant, one might argue that a lung damaged by smoking (not severely) would be better than no functioning lung at all. But lungs of smokers may be mild or moderately damaged (COPD), and also carry the risk of lung cancer, especially with post operative chronic use of immune suppressors. Nevertheless, in a dying patient, the prolongation of life -- however long that may be -- [and] the benefit is clear."

Although these findings have clear implications for the United Kingdom, it "is important to realize that the relation between risk of dying on the waiting list and the benefit of accepting a transplant from a donor with a substantial smoking history can vary by country and center," Dr. Shaf Keshavjee and Dr. Marcelo Cypel of the Toronto Lung Transplant Program of the University Health Network in Canada, wrote in an accompanying commentary in the journal.

More information

The U.S. National Heart, Lung, and Blood Institute has more about lung transplantation.

-- Robert Preidt

SOURCE: Len Horovitz, M.D., pulmonary specialist, Lenox Hill Hospital, New York City; Associated Press; The Lancet, news release, May 28, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Nicotine replacement therapy is over-promoted since most ex-smokers quit unassisted
2. Genetic variant greatly increases lung cancer risk for light smokers
3. Longtime Smokers May Find Protection From Parkinsons
4. Blood Vessels Bounce Back Once Smokers Quit
5. Gene is linked to lung cancer development in never-smokers
6. Gene Linked to Lung Cancer Risk in Non-Smokers
7. Movies Trigger Young Adult Smokers to Light Up
8. Researchers discover new approach for identifying smokers at highest risk for developing lung cancer
9. Arteries Age Twice as Fast in Smokers
10. Alcohol consumption may protect against risk of AD, particularly in female nonsmokers
11. Women Smokers Targeted on World No Tobacco Day
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Use of Smokers' Lungs for Transplant Has Pros, Cons
(Date:10/13/2017)... ... ... While it’s often important to take certain medications during the night, finding ... identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX to ... the need to turn on a light when taking medication during the night, allowing ...
(Date:10/13/2017)... ... 2017 , ... PurhealthRX , a leading Health and Nutrition Company, is ... to full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing ... easily incorporated into liquid products, while reducing costs to end users. , The team ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading ... to advocate for action towards gender equality at their inaugural Summit in New York ... globe, and reached a social audience of over 3 million. To watch the Mobilize ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
Breaking Medicine News(10 mins):
(Date:9/25/2017)... PROVIDENCE, R.I. , Sept. 25, 2017 /PRNewswire/ ... immunogenicity assessment, vaccine design, and immune-engineering today announced ... focused on the development of personalized therapeutic cancer ... and has provided exclusive access to enabling technologies ... MSc Eng., MBA will lead EpiVax Oncology as ...
(Date:9/19/2017)... LOUISVILLE, Ky. , Sept. 19, 2017   ZirMed ... and predictive analytics, today announced that it has been ranked ... the Black Book™ Rankings 2017 User Survey. ZirMed ... software solution for large hospitals and medical centers over 200 ... in Black Book,s healthcare technology user survey history. ...
(Date:9/12/2017)... -- Consumer reviews on the independent review site Consumer Affairs ... for hearing aids, ranking it higher than Miracle Ear ™, ... ... Hearing Aids ... store that provides high performance, state-of-the-art, German-engineered hearing aids directly to ...
Breaking Medicine Technology: