Navigation Links
Urine test may determine if a smoker is at risk for lung cancer
Date:4/19/2009

DENVER Researchers may have uncovered why lung cancer afflicts some smokers and not others, according to data presented at the American Association for Cancer Research 100th Annual Meeting 2009.

"A history of smoking has always been thought of as a predictor of lung cancer, but it is actually not very accurate," said Jian-Min Yuan, Ph.D., M.D., associate professor of public health at the University of Minnesota. "Smoking absolutely increases your risk, but why it does so in some people but not others is a big question."

Yuan and colleagues hypothesized that the presence of the metabolite NNAL in a patient's urine might predict risk of lung cancer. This metabolite has been shown to induce lung cancer in laboratory animals, but the effect in humans had not yet been studied.

Researchers collected data from 18,244 men enrolled in the Shanghai Cohort Study and 63,257 men and women from the Singapore Chinese Health Study. In addition to in-person interviews to assess levels of cigarette smoking, dietary and other lifestyle factors, researchers collected blood and urine samples from more than 50,000 patients.

To evaluate the impact of NNAL, researchers identified 246 current smokers who later developed lung cancer and 245 smokers who did not develop lung cancer during the 10-year period following initial interview and collection of urine samples.

Levels of NNAL in the urine were divided into three groups. Compared to those with the lowest levels, patients with a mid-range level of NNAL had a 43 percent increased risk of lung cancer, while those at the highest level had a more than two-fold increased risk of lung cancer after taking into account the effect of number of cigarettes per day, number of years of smoking, and urinary levels of cotinine on lung cancer risk.

Levels of nicotine in the urine were also calculated. Those with the highest levels of nicotine and NNAL had an 8.5-fold increase in the risk of lu
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Human Urine Safe, Productive Fertilizer
2. Contamination from depleted uranium found in urine 20 years later
3. Urine Test Results Can Point to Heart Dangers
4. Urine protein may be present before hypertension diagnosis in at-risk adolescents
5. Super Prostate Product - More Beta-sitosterol, all-natural Best Prostate(TM) Formula for Enlarged Prostate and BPH - Increases Urine Flow, Reduces Waking and Improves Quality of Life
6. Urine Test May One Day Predict Prostate Cancer
7. Taurine: Key to the visual toxicity of an anti-epileptic drug for children?
8. Breath or urine analysis may detect cancer, diabetes
9. Urine Test May ID Unhealthy Diets
10. Urine Test Could Gauge Smokers Lung Cancer Risk
11. Federal research plan to determine nanotech risks fails to deliver
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. ... chronic illnesses can receive effective, less expensive care from a ... to a team of dedicated health care professionals, a new ... ill and need either hospitalization or a trip to the ... home clinic at the University of Texas in Houston versus ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... closing in on a "fountain of youth" drug that can ... older adults, a new study suggests. Seniors received a ... that targets a genetic signaling pathway linked to aging and ... The experimental medication, a version of the drug ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Plugin creators ... ProFire 5k. A fully customizable business presentation tool made ... “Adding the ProFire 5k business tool, users can now ... Austin, CEO of Pixel Film Studios. “ProFire 5k gives ... style to add professionalism to a presentation” , Pixel ...
(Date:12/24/2014)... AlignLife of Wauwatosa loves helping those in the ... holiday season, AlignLife looks forward to their annual toy drive. ... Mahalko-Leonhardt, owner of AlignLife. "It brings our patients as well ... able to give kids toys for Christmas who would be ... of our patients." , The 70 toys were donated to ...
(Date:12/24/2014)... Recently, iFitDress.com, a famous dress manufacturer and retailer, ... $150 . All these items are brand new; they are ... been updated with the new range of high quality prom ... All iFitDress.com’s designs are made according to the latest trends. ... Every outfit from the company is handpicked by skilled tailors. ...
Breaking Medicine News(10 mins):Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Announcing a new ProFire 5k plugin from Pixel Film Studios for Final Cut Pro X Professionals 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Many Prom Dresses under 150 from Well-known Dress Manufacturer iFitDress.com 2
... the artery-opening devices , , FRIDAY, May 9 (HealthDay News) ... tiny tools that have extended the lives of millions ... their arteries. , The wire metal mesh tubes, when ... artery and ensure a constant supply of blood to ...
... Week with Signing Bonuses, Raises, SAGINAW, Mich., May ... Saginaw voted overwhelmingly last,night to accept their first labor ... year wage increases of 4 percent., (Logo: ... Week I have had in years. The money is,important, ...
... May 9 Brookdale Senior,Living Inc. (NYSE: BKD ... the Company at the Bank of America 2008 Health ... Mandalay Bay in Las Vegas,Nevada at 4:40 p.m. PDT ... being webcast live and can be accessed through the,Bank ...
... May 9 Tim Booth, a 20-year health,care ... CEO of PrePak Systems,Inc., a turnkey pharmaceutical packaging ... last week by the company,s parent, PrePak,Holdings, which ... and,expansion with financial support from its largest shareholders, ...
... May 9 Almost Family, Inc.,(Nasdaq: AFAM ... nursing,services, today announced that the underwriter of the ... and purchased 262,500,additional shares of common stock at ... the over-allotment, the Company sold 2,512,500 shares,in the ...
... painful periods, glaucoma, depression and many other diseases, ... -- A new class of drugs called vaptans ... of conditions including painful periods, brain hemorrhage, psychotic ... short for vasopressin-receptor antagonists, work by targeting the ...
Cached Medicine News:Health News:Drug-Coated Stents Still Spark Debate 2Health News:Drug-Coated Stents Still Spark Debate 3Health News:Saginaw Nurses Approve First Contract 2Health News:Booth Joins PrePak Systems for Growth, Expansion 2Health News:Almost Family, Inc. Announces Exercise of Over-Allotment Option 2Health News:New Class of Drugs Might Treat Many Conditions 2
(Date:12/24/2014)... -- In response to urgent requests from the Deputy Minister of ... , Direct Relief delivered two 10-bed medical tents to ... local health workers who contract Ebola while fighting the outbreak. ... was constructed for foreign health care workers who may contract ... Sierra Leonean health workers. With Sierra ...
(Date:12/22/2014)... , Dec. 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), ... CytoSorb® blood purification technology to help fight deadly ... 28 countries worldwide, today announced the appointment of ... FACS, as its Senior Vice President of Clinical ... Dr. Di Russo is an accomplished ...
(Date:12/22/2014)... and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) has announced ... Market" report to their offering. ... focuses on the developments in the self-monitoring blood glucose ... Reimbursement analysis and the effects of competitive bidding have ... SMBG meters have been performed, based on the various ...
Breaking Medicine Technology:First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5US Self-monitoring Blood Glucose Market 2
... WASHINGTON , July 28 Today FRC Action joined 19 pro-life groups ... requesting that Ella, a drug under consideration for FDA approval that can cause abortions but ... , , ... Vice President , made the following comments: , ...
... July 28 Delcath Systems, Inc. (Nasdaq: DCTH ) announced today ... Management Access Conference in New York, NY on Tuesday, August ... Chief Financial Officer, will review the company,s business strategy and recent corporate developments. ... Attendance at this conference is ...
Cached Medicine Technology:FRC Action and Pro-Life Coalition Urge the FDA to Reject New Abortion-Causing Drug 2Delcath to Present at the 2010 Wedbush Securities Life Sciences Best Ideas Management Access Conference 2Delcath to Present at the 2010 Wedbush Securities Life Sciences Best Ideas Management Access Conference 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: