Navigation Links
Urine test may determine if a smoker is at risk for lung cancer
Date:4/19/2009

DENVER Researchers may have uncovered why lung cancer afflicts some smokers and not others, according to data presented at the American Association for Cancer Research 100th Annual Meeting 2009.

"A history of smoking has always been thought of as a predictor of lung cancer, but it is actually not very accurate," said Jian-Min Yuan, Ph.D., M.D., associate professor of public health at the University of Minnesota. "Smoking absolutely increases your risk, but why it does so in some people but not others is a big question."

Yuan and colleagues hypothesized that the presence of the metabolite NNAL in a patient's urine might predict risk of lung cancer. This metabolite has been shown to induce lung cancer in laboratory animals, but the effect in humans had not yet been studied.

Researchers collected data from 18,244 men enrolled in the Shanghai Cohort Study and 63,257 men and women from the Singapore Chinese Health Study. In addition to in-person interviews to assess levels of cigarette smoking, dietary and other lifestyle factors, researchers collected blood and urine samples from more than 50,000 patients.

To evaluate the impact of NNAL, researchers identified 246 current smokers who later developed lung cancer and 245 smokers who did not develop lung cancer during the 10-year period following initial interview and collection of urine samples.

Levels of NNAL in the urine were divided into three groups. Compared to those with the lowest levels, patients with a mid-range level of NNAL had a 43 percent increased risk of lung cancer, while those at the highest level had a more than two-fold increased risk of lung cancer after taking into account the effect of number of cigarettes per day, number of years of smoking, and urinary levels of cotinine on lung cancer risk.

Levels of nicotine in the urine were also calculated. Those with the highest levels of nicotine and NNAL had an 8.5-fold increase in the risk of lu
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Human Urine Safe, Productive Fertilizer
2. Contamination from depleted uranium found in urine 20 years later
3. Urine Test Results Can Point to Heart Dangers
4. Urine protein may be present before hypertension diagnosis in at-risk adolescents
5. Super Prostate Product - More Beta-sitosterol, all-natural Best Prostate(TM) Formula for Enlarged Prostate and BPH - Increases Urine Flow, Reduces Waking and Improves Quality of Life
6. Urine Test May One Day Predict Prostate Cancer
7. Taurine: Key to the visual toxicity of an anti-epileptic drug for children?
8. Breath or urine analysis may detect cancer, diabetes
9. Urine Test May ID Unhealthy Diets
10. Urine Test Could Gauge Smokers Lung Cancer Risk
11. Federal research plan to determine nanotech risks fails to deliver
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... According to a new Aegis Living Study on ... likely to worry about what will happen to their memory ... 69% Silent Generation), which may help explain why nearly half ... particularly Millennials (47%), Gen X’ers (51%), and Boomers (43%). The ... among more than 2,000 U.S. adults ages 18+. , ...
(Date:5/22/2015)... 2015 The dentist in ... that they are now offering complimentary consultations to ... treatments. At consultations, patients can discuss their candidacy ... certain treatments can achieve and whether alternative options ... initial appointment. If treatments are chosen, patients can ...
(Date:5/22/2015)... 22, 2015 Wimbledon Health Partners, the ... (EKG), echocardiogram and NCV testing , is proud ... respected All American National athlete, to the Wimbledon Athletics ... the high level of testing and information it provides ... their athletic trainers, this way they can focus on ...
(Date:5/22/2015)... In April 2006, Veatch Consulting opened for ... they have concentrated their focus to working with over ... of this growth and their goals to better serve ... Colorado, Cleveland, Ohio, Houston, Texas and now Dallas, Texas. ... offices, dental start ups, orthodontic practices, pediatric dental practices, ...
(Date:5/22/2015)... 22, 2015 In efforts to offer ... section containing particular muscles stretches has been a large ... of stretches now complete, Chunk Fitness envisions a mid-June ... be filmed and released at a later point in ... here: http://www.chunkfitness.com/stretches . , About the Company: Chunk ...
Breaking Medicine News(10 mins):Health News:New Study Reveals America’s Fear of Aging 2Health News:New Study Reveals America’s Fear of Aging 3Health News:West Hollywood Dental Office, Sunset Plaza Dental is Now Offering Complimentary Consultations 2Health News:Wimbledon Athletics Recruits Team USA Athlete 2Health News:Wimbledon Athletics Recruits Team USA Athlete 3
... paramedics shortens time to specialized treatment, study finds , ... people with chest pain who are given an electrocardiogram ... long to receive treatment to open their arteries. , ... and go directly to the cardiac catheterization laboratory for ...
... ... Flying Aid and Orange Israel Telecommunications have announced today that they are aiding ... children. This will be the first of three stages of establishing the orphanage ... IDF - will be providing fresh, running drinking water, an electric generator, tents ...
... less likely to opt for surgery than county hospitals, ... The type of treatment received by prostate cancer patients ... where they receive care, a new U.S. study has ... in county hospitals, while patients in private facilities ...
... , WASHINGTON , Jan. 25 ... disability advocates, The HSC Foundation is currently accepting applications for its ... the ages of 14 and 26 in the Washington, DC ... , Applicants will be evaluated on their current and previous work ...
... , ... OrthoAccel Technologies, Inc., developers of the AcceleDent System , ... week that it has engaged Waldemar "Val" B. Szwajkowski ... the Company will be primarily focused on strategic development of ...
... ... 5W Public Relations ( http://www.5wpr.com ) , one of the 25 ... of Philip Stein ( http://www.philipstein.com/ ) watches to its versatile roster ... quickly grown to be a leader in watches and other lifestyle products using ...
Cached Medicine News:Health News:Israel Flying Aid, Orange Israel Create Haiti Orphanage, Provide Humanitarian Aid 2Health News:Israel Flying Aid, Orange Israel Create Haiti Orphanage, Provide Humanitarian Aid 3Health News:Israel Flying Aid, Orange Israel Create Haiti Orphanage, Provide Humanitarian Aid 4Health News:Prostate Cancer Care Varies By Hospital Type 2Health News:DC Nonprofit Searches for Next Generation of Disability Advocates 2Health News:Industry Advisor Joins OrthoAccel Technologies, Inc. 2Health News:Industry Advisor Joins OrthoAccel Technologies, Inc. 3Health News:Industry Advisor Joins OrthoAccel Technologies, Inc. 4Health News:5W Public Relations Adds Philip Stein Watches to Its Fashion & Lifestyle Client Roster 2Health News:5W Public Relations Adds Philip Stein Watches to Its Fashion & Lifestyle Client Roster 3
(Date:5/22/2015)... 22, 2015 According to a ... Product (Consumables, Instruments, Services), by Test Type (Indirect, Enzyme-based, ... Cytometry), by End Users - Global Forecast to 2020", ... expected to reach $736.85 Million by 2020 from $452.36 ... Browse 71 market data Tables and ...
(Date:5/22/2015)... BOSTON , May 22, 2015   InspireMD, Inc. ... in stent embolic protection systems ("EPS"), today announced that its ... PARADIGM, lead by principle investigator Prof. Piotr Musialek , ... in Paris, France . PARADIGM, ... pe R cutaneous c A roti D revascularization ...
(Date:5/22/2015)... R.I. , May 22, 2015 ... once-daily central nervous system stimulant indicated for the ... to patients beginning Summer 2015. ... XR received approval from the U.S. Food and ... is an extended-release formulation of methylphenidate capsule with ...
Breaking Medicine Technology:Oxidative Stress Assays Market Worth $736.85 Million by 2020 2Oxidative Stress Assays Market Worth $736.85 Million by 2020 3Oxidative Stress Assays Market Worth $736.85 Million by 2020 4InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 2Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 3Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 4Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 5Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 6
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: