Navigation Links
Urine test best detects alcohol use in liver transplant candidates, recipients
Date:5/8/2014

Researchers from Italy confirm that urinary ethyl glucuronide (uEtG) accurately detects alcohol consumption in liver transplant candidates and recipients. The study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, suggests that a combination of uEtG and the Alcohol Use Disorders Identification Test for alcohol consumption (AUDIT-c) are best in alerting doctors to alcohol consumption by patients undergoing evaluation for liver transplantation or who have received liver transplants.

Alcoholic liver disease is one of the most common reasons for liver transplantation in Europe and the U.S say experts. Furthermore, studies suggest that up to 49% of liver transplant recipients struggle with alcohol relapse, which may cause complications with the graft. In fact, medical evidence found that transplant recipients who relapse have a poorer survival rate than abstinent patients.

"Assessing alcohol consumption is crucial in the selection of liver transplant candidates," explains Dr. Paolo Angeli from the University of Padova in Italy. "Equally important is the ability to detect alcohol use in liver transplant recipients so early intervention for alcohol relapse can take place."

For the present study the research team evaluated the effectiveness of uEtg, AUDIT-c, serum ethanol (sETOH), urinary ethanol (uETOH), and carbohydrate-deficient transferrin (CDT) in assessing drinking status in 121 liver transplant candidates and recipients. Participants provided blood and urine samples at each visit to detect all alcohol markers.

Researchers detected alcohol consumption in 31% of participants, with uEtG found to be the strongest marker of alcohol use. Compared to CDT, uEtG was also more accurate in predicting the amount of alcohol consumption. When used together uEtG and AUDIT-c were more accurate in assessing alcohol consumption than CDT and AUDIT-c. In patients with a negative AUDIT-c, uEtG was the most effective indicator of drinking status.

The authors recommend that AUDIT-c and uEtG be routinely used in transplant candidates and recipients to monitor drinking status. Dr. Angeli concludes, "It's vital that patients abstain from damaging drinking behavior following liver transplant to avoid graft loss or even death. When used together, uEtG and AUDIT-c provide an important tool in the management of transplant patients at risk for alcohol relapse."


'/>"/>

Contact: Dawn Peters
sciencenewsroom@wiley.com
781-388-8408
Wiley
Source:Eurekalert

Related medicine news :

1. Electronic nose sniffs out prostate cancer using urine samples
2. InventHelp Inventor Develops Infant Urine Collection Device (OCM-592)
3. EZ-P Enables Female Users to Give Urine Samples More Conveniently - Designed by InventHelp Client (DLL-2593)
4. Protein-based urine test predicts kidney transplant outcomes
5. Stem cells in urine easy to isolate and have potential for numerous therapies
6. Urine biomarker test can diagnose as well as predict rejection of transplanted kidneys
7. ATAGO Urine Specific Gravity Refractometers Continue to Catch Drug Test Cheaters
8. RI Hospital: Nearly half of older women diagnosed with UTI not confirmed in urine culture
9. Microscopic blood in urine unreliable indicator of urinary tract cancer
10. InventHelp Client Patents “LessMess” – Invention Could Reduce Messes and Smells Caused by Splashed Urine
11. Purines fend off surgery-related damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... N.J. (PRWEB) , ... June 27, 2016 , ... Quality ... sources, yet in many ways they remain in the eye of the beholder, according ... (EBO), a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
Breaking Medicine Technology: