Navigation Links
Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
Date:2/16/2010

DALLAS Feb. 15, 2010 Simple urine tests for four proteins might be able to detect early kidney disease in people with lupus, researchers at UT Southwestern Medical Center have found in an animal study.

Although it might take years before such tests could be used clinically, the findings suggest they could pinpoint kidney disease better than tests currently in use, the researchers said.

"Our goal was to accurately detect something in the urine that appears only in disease," said Dr. Chandra Mohan, professor of internal medicine and immunology at UT Southwestern and senior author of the study, available online and in today's issue of The Journal of Immunology.

"If this testing regimen proves effective in humans, physicians might be able to predict and diagnose kidney damage noninvasively, as well as monitor whether treatments are working."

Kidney disease is the major cause of death and disability in lupus patients, Dr. Mohan said. Early detection and treatment lead to a longer and better-quality life.

The researchers found that in mice, four proteins protease, PGDS, SAP and SOD show up in larger quantities in urine as kidney damage progresses. Each of these proteins is either present in humans or has a human equivalent. The researchers currently are studying whether the same correlation between urinary protein levels and disease occurs in humans.

Lupus is one of many autoimmune diseases that attack internal organs, tissues, joints and other parts of the body. The researchers focused on systemic lupus erythematosus affecting the kidneys, the most common and serious form of lupus.

Currently, kidney damage in humans is detected by performing a kidney biopsy, Dr. Mohan said. A kidney biopsy involves taking a tissue sample with a needle, a process that is invasive and can be stressful to patients.

In the current study, the researchers used mice that have a condition similar to human lupus. They screened urine for proteins both before and after the mice showed symptoms of kidney disease and found that 71 proteins appeared in urine after the illness became physically evident.

The researchers then focused on four proteins that were present in high levels after symptoms appeared. These proteins or their analogs had not previously been known to be present in the urine of patients or mice with lupus kidney disease.

Dr. Mohan said monitoring urinary levels of these four proteins might also reveal more about the mechanisms of lupus. Each protein is involved in a different biochemical process, so the stage of the disease at which each appears in urine might prove informative, he said.

Testing for these proteins might also have the potential to monitor kidney damage that results from diabetes, hypertension and other conditions, said Dr. Mohan.


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Protein Levels in Urine Help Predict Kidney Function
2. Excess protein in urine is indicator of heart disease risk in whites, but not blacks
3. Urine Sample May Reveal Sleep Disorder in Kids
4. Urine test for pediatric obstructive sleep apnea possible
5. Appeals Court Rules in Favor of Prometheus, Upholds the Patentability of Its Claims for Methods of Thiopurine Metabolite Testing
6. Dominion Diagnostics -- The Only Specialty Urine Drug Monitoring Laboratory to Offer Quantitative Detection of Tapentadol (Nucynta(TM)) by LC/MS/MS
7. Urine Test for Chlamydia Shown Effective in Men
8. New Urine Drug Test to Detect for 6 Major Drugs, Now Available at Drugstore.com -- 'DrugConfirm' Is a New Revolutionary Urine Drug Test
9. Experimental Urine Test Spots Appendicitis
10. Urine Test Predicts Vein Clot Risk
11. Urine Test for Heart Disease Shows Promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/26/2016)... ... , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... a whole new perspective by using the title layers in ProSlice Levels to ... ProSlice Levels contains over 30 Different presets to choose from. FCPX users ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
(Date:6/23/2016)... WAYNE, Pa. , June 23, 2016 ... provider, will launch its next generation clinical outcomes platform, Bracket ... DIA Meeting held on June 26 – 30, 2016 in ... 6.0, the first electronic Clinical Outcome Assessment product of its ... DIA Booth #715. Bracket eCOA 6.0 is a ...
(Date:6/23/2016)... June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations ... Latin America . ... ... ... ...
Breaking Medicine Technology: